201730-11-2
Chemical Structure
(S)-3,4-DCPG
Synonym(s): (S)-3,4-Dicarboxyphenylglycine
- CAS No.: 201730-11-2
- Formula:C10H9NO6
- Molecular Weight:239.18
IUPAC Name: (S)-4-(amino(carboxy)methyl)phthalic acid
InChIKey: IJVMOGKBEVRBPP-ZETCQYMHSA-N
SMILES: OC(C1=C(C=CC([C@H](N)C(O)=O)=C1)C(O)=O)=O
Biological Activity: (S)-3,4-DCPG ((S)-3,4-Dicarboxyphenylglycine) is a potent and selective mGlu8a receptor agonist with an EC50 of 31 nM for human mGlu8a. (S)-3,4-DCPG inhibits Forskolin (HY-15371)-stimulated cAMP formation by activating mGlu8, and modulates presynaptic glutamatergic transmission and synaptic plasticity. (S)-3,4-DCPG can be used in research on inflammatory pain, neuropathic pain, autism spectrum disorder, and glutamatergic synaptic plasticity[1][2][3].
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(S)-3,4-DCPG | 98% | (S)-3,4-DCPG ((S)-3,4-Dicarboxyphenylglycine) is a potent and selective mGlu8a receptor agonist with an EC50 of 31 nM for human mGlu8a. (S)-3,4-DCPG inhibits Forskolin (HY-15371)-stimulated cAMP formation by activating mGlu8, and modulates presynaptic glutamatergic transmission and synaptic plasticity. (S)-3,4-DCPG can be used in research on inflammatory pain, neuropathic pain, autism spectrum disorder, and glutamatergic synaptic plasticity. | ||||||||||||||||||||
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- [1]. Thomas NK, et al. (S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord. Neuropharmacology. 2001 Mar;40(3):311-8. [Content Brief]
- [2]. Gholipour P, et al. Effects of (S)-3,4-DCPG, an mGlu8 receptor agonist, on hippocampal long-term potentiation at perforant pathway-dentate gyrus synapses in prenatal valproic acid-induced rat model of autism. Scientific reports. 2024 Jun 07;14(1):13168. [Content Brief]
- [3]. Marabese I, et al. Effects of (S)-3,4-DCPG, an mGlu8 receptor agonist, on inflammatory and neuropathic pain in mice. Neuropharmacology. 2007 Feb;52(2):253-62. [Content Brief]
Keywords
