201730-11-2
201730-11-2
Chemical Structure
(S)-3,4-DCPG
Synonym(s): (S)-3,4-Dicarboxyphenylglycine
- CAS. Nr.: 201730-11-2
- Formula:C10H9NO6
- Molecular Weight:239.18
IUPAC Name: (S)-4-(amino(carboxy)methyl)phthalic acid
InChIKey: IJVMOGKBEVRBPP-ZETCQYMHSA-N
SMILES: OC(C1=C(C=CC([C@H](N)C(O)=O)=C1)C(O)=O)=O
Biological Activity: (S)-3,4-DCPG ((S)-3,4-Dicarboxyphenylglycine) is a potent and selective mGlu8a receptor agonist with an EC50 of 31 nM for human mGlu8a. (S)-3,4-DCPG inhibits Forskolin (HY-15371)-stimulated cAMP formation by activating mGlu8, and modulates presynaptic glutamatergic transmission and synaptic plasticity. (S)-3,4-DCPG can be used in research on inflammatory pain, neuropathic pain, autism spectrum disorder, and glutamatergic synaptic plasticity[1][2][3].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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(S)-3,4-DCPG | 98% | (S)-3,4-DCPG ((S)-3,4-Dicarboxyphenylglycine) is a potent and selective mGlu8a receptor agonist with an EC50 of 31 nM for human mGlu8a. (S)-3,4-DCPG inhibits Forskolin (HY-15371)-stimulated cAMP formation by activating mGlu8, and modulates presynaptic glutamatergic transmission and synaptic plasticity. (S)-3,4-DCPG can be used in research on inflammatory pain, neuropathic pain, autism spectrum disorder, and glutamatergic synaptic plasticity. | ||||||||||||||||||||
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LY367385 hydrochloride (Standard) | LY367385 hydrochloride (Standard) is the analytical standard of LY367385 (hydrochloride) (HY-107515A). This product is intended for research and analytical applications. LY367385 hydrochloride is a highly selective and potent mGluR1a antagonist. LY367385 hydrochloride has an IC50 of 8.8 μM for inhibiting of quisqualate-induced phosphoinositide (PI) hydrolysis, compared with >100 μM for mGlu5a. LY367385 hydrochloride has neuroprotective, anticonvulsant and antiepileptic effects. | |||||||||||||||||||||
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(R,S)-3,4-Dicarboxyphenylglycine | (R,S)-3,4-Dicarboxyphenylglycine ((RS)-3,4-DCPG) is an AMPA receptor antagonist. (R,S)-3,4-Dicarboxyphenylglycine antagonizes AMPA-mediated depolarization of motor neurons in neonatal rats. (R,S)-3,4-Dicarboxyphenylglycine can be used in the study of neurological diseases. | |||||||||||||||||||||
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(R)-3,4-DCPG | (R)-3,4-DCPG is an AMPA and NMDA antagonist with a Kd of 77 μM for AMPA. (R)-3,4-DCPG complete antagonizes the NMDA-induced depolarization at a concentration of 500 μM. (R)-3,4-DCPG exhibits a weak antagonistic effect on kainate-induced depolarizations. | |||||||||||||||||||||
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Benzene-1,2,4,5-tetracarboxylic acid | 99.59% | Benzene-1,2,4,5-tetracarboxylic acid (Pyromellitic acid hydrate) is a metal-organic framework (MOF). | ||||||||||||||||||||
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2-Chlorobenzene-1,3,5-tricarboxylic acid | 2-Chlorobenzene-1,3,5-tricarboxylic acid is a metal-organic framework (MOF). | |||||||||||||||||||||
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Methyl-benzene-1,3,5-tricarboxylic acid | Methyl-benzene-1,3,5-tricarboxylic acid (Methyltrimesinsaeure) is a metal-organic framework (MOF). | |||||||||||||||||||||
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2-Bromobenzene-1,3,5-tricarboxylic acid | 2-Bromobenzene-1,3,5-tricarboxylic acid (2-Bromo-benzene-1,3,5-tricarboxylic acid) is a metal-organic framework (MOF). | |||||||||||||||||||||
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Benzene-1,2,3,5-tetracarboxylic acid | Benzene-1,2,3,5-tetracarboxylic acid is a metal-organic framework (MOF). | |||||||||||||||||||||
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2-Fluorobenzene-1,3,5-tricarboxylic acid | 2-Fluorobenzene-1,3,5-tricarboxylic acid is a metal-organic framework (MOF). | |||||||||||||||||||||
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Benzene-1,2,3,4-tetracarboxylic acid | Benzene-1,2,3,4-tetracarboxylic acid is a metal-organic framework (MOF). | |||||||||||||||||||||
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References
- [1]. Thomas NK, et al. (S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord. Neuropharmacology. 2001 Mar;40(3):311-8. [Content Brief]
- [2]. Gholipour P, et al. Effects of (S)-3,4-DCPG, an mGlu8 receptor agonist, on hippocampal long-term potentiation at perforant pathway-dentate gyrus synapses in prenatal valproic acid-induced rat model of autism. Scientific reports. 2024 Jun 07;14(1):13168. [Content Brief]
- [3]. Marabese I, et al. Effects of (S)-3,4-DCPG, an mGlu8 receptor agonist, on inflammatory and neuropathic pain in mice. Neuropharmacology. 2007 Feb;52(2):253-62. [Content Brief]
