1. GPCR/G Protein
    Neuronal Signaling
  2. mGluR
  3. Pomaglumetad methionil hydrochloride

Pomaglumetad methionil hydrochloride (Synonyms: LY2140023 hydrochloride)

Cat. No.: HY-105040C Purity: 98.20% ee.: 99.25%
Handling Instructions

Pomaglumetad methionil hydrochloride (LY2140023 hydrochloride) is an orally active, methionine prodrug of the selective mGlu2/3 receptor agonist LY404039. Pomaglumetad methionil hydrochloride has the potential for schizophrenia research.

For research use only. We do not sell to patients.

Pomaglumetad methionil hydrochloride Chemical Structure

Pomaglumetad methionil hydrochloride Chemical Structure

CAS No. : 635318-26-2

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5 mg USD 650 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Pomaglumetad methionil hydrochloride (LY2140023 hydrochloride) is an orally active, methionine prodrug of the selective mGlu2/3 receptor agonist LY404039. Pomaglumetad methionil hydrochloride has the potential for schizophrenia research[1][2].

IC50 & Target[1]

mGluR2

 

mGluR3

 

In Vitro

Pomaglumetad methionil (LY2140023) is a high-affinity peptide transporter 1 (PEPT1) substrate with a Km value of ~30 µM[2].
LY2140023 is active against [14C]Gly-Sar with an IC50 value of 0.018 mM[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Pomaglumetad methionil (LY2140023; orally; 3-300 mg/kg; once daily for 7 days) dose-dependent increases the levels of the dopamine metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Fischer rats (approximately 250 g)[1]
Dosage: 3 mg/kg, 10 mg/kg, and 300 mg/kg
Administration: Orally; once daily for 7 days
Result: Dose-dependent increased the levels of the dopamine metabolites DOPAC and HVA.
Molecular Weight

402.87

Formula

C₁₂H₁₉ClN₂O₇S₂

CAS No.

635318-26-2

SMILES

CSCC[[email protected]](N)C(N[[email protected]]([[email protected]@]1([H])[[email protected]](S2(=O)=O)([H])[[email protected]@H]1C(O)=O)(C2)C(O)=O)=O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

References
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Keywords:

Pomaglumetad methionilLY2140023LY 2140023LY-2140023mGluRMetabotropic glutamate receptorsMethioninemGlu2mGlu3schizophreniaPepT1oralInhibitorinhibitorinhibit

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Pomaglumetad methionil hydrochloride
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