1. GPCR/G Protein
    Neuronal Signaling
  2. mGluR
  3. LY2140023

LY2140023 

Cat. No.: HY-14554
Handling Instructions

LY2140023 is an orally active prodrug of LY404039. LY404039 is a selective metabotropic glutamate 2/3 receptor agonist. LY2140023 is currently for the treatment of schizophrenia.

For research use only. We do not sell to patients.

LY2140023 Chemical Structure

LY2140023 Chemical Structure

CAS No. : 635318-55-7

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Description

LY2140023 is an orally active prodrug of LY404039. LY404039 is a selective metabotropic glutamate 2/3 receptor agonist. LY2140023 is currently for the treatment of schizophrenia[1].

IC50 & Target[1]

mGluR2

 

mGluR3

 

In Vivo

LY2140023 (orally; 3, 10, and 300 mg/kg; once daily for 7 days) dose-dependent increases the levels of the dopamine metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA)[1].

Animal Model: Male Fischer rats (approximately 250 g)[1]
Dosage: 3, 10, and 300 mg/kg
Administration: Orally; once daily for 7 days
Result: Dose-dependent increased the levels of the dopamine metabolites DOPAC and HVA.
Molecular Weight

366.41

Formula

C₁₂H₁₈N₂O₇S₂

CAS No.

635318-55-7

SMILES

O=C([[email protected]]1(NC([[email protected]@H](N)CCSC)=O)CS([[email protected]@]2([H])[[email protected]](C(O)=O)[[email protected]@]12[H])(=O)=O)O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

LY2140023LY 2140023LY-2140023mGluRMetabotropic glutamate receptorsorallyprodrugLY404039metabotropicglutamateschizophreniaInhibitorinhibitorinhibit

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