2. GPCR/G Protein
    Neuronal Signaling
  3. mGluR
  4. Pomaglumetad methionil anhydrous

Pomaglumetad methionil anhydrous  (Synonyms: LY2140023)

Cat. No.: HY-14554
Handling Instructions

Pomaglumetad methionil anhydrous (LY2140023) is an orally active, methionine prodrug of the selective mGlu2/3 receptor agonist LY404039. LY2140023 has the potential for schizophrenia research.

For research use only. We do not sell to patients.

Pomaglumetad methionil anhydrous Chemical Structure

Pomaglumetad methionil anhydrous Chemical Structure

CAS No. : 635318-55-7

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  • Biological Activity

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Description

Pomaglumetad methionil anhydrous (LY2140023) is an orally active, methionine prodrug of the selective mGlu2/3 receptor agonist LY404039. LY2140023 has the potential for schizophrenia research[1][2].

IC50 & Target[1]

mGluR2

 

mGluR3

 

In Vitro

Pomaglumetad methionil (LY2140023) is a high-affinity peptide transporter 1 (PEPT1) substrate with a Km value of ~30 µM[2].
LY2140023 is active against [14C]Gly-Sar with an IC50 value of 0.018 mM[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

Pomaglumetad methionil (LY2140023; orally; 3-300 mg/kg; once daily for 7 days) dose-dependent increases the levels of the dopamine metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Fischer rats (approximately 250 g)[1]
Dosage: 3, 10, and 300 mg/kg
Administration: Orally; once daily for 7 days
Result: Dose-dependent increased the levels of the dopamine metabolites DOPAC and HVA.
Clinical Trial
Molecular Weight

366.41

Formula

C12H18N2O7S2
CAS No.
SMILES

O=C([[email protected]]1(NC([[email protected]@H](N)CCSC)=O)CS([[email protected]@]2([H])[[email protected]](C(O)=O)[[email protected]@]12[H])(=O)=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 13.33 mg/mL (36.38 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7292 mL 13.6459 mL 27.2918 mL
5 mM 0.5458 mL 2.7292 mL 5.4584 mL
10 mM 0.2729 mL 1.3646 mL 2.7292 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.33 mg/mL (3.63 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 1.33 mg/mL (3.63 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.33 mg/mL (3.63 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Pomaglumetad methionil635318-55-7LY2140023LY 2140023LY-2140023mGluRMetabotropic glutamate receptorsorallyprodrugLY404039metabotropicglutamateschizophreniaInhibitorinhibitorinhibit

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