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  3. Pomaglumetad methionil anhydrous

Pomaglumetad methionil anhydrous (Synonyms: LY2140023)

Cat. No.: HY-14554
Handling Instructions

Pomaglumetad methionil anhydrous (LY2140023) is an orally active, methionine prodrug of the selective mGlu2/3 receptor agonist LY404039. LY2140023 has the potential for schizophrenia research.

For research use only. We do not sell to patients.

Pomaglumetad methionil anhydrous Chemical Structure

Pomaglumetad methionil anhydrous Chemical Structure

CAS No. : 635318-55-7

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Description

Pomaglumetad methionil anhydrous (LY2140023) is an orally active, methionine prodrug of the selective mGlu2/3 receptor agonist LY404039. LY2140023 has the potential for schizophrenia research[1][2].

IC50 & Target

mGluR2

 

mGluR3

 

In Vitro

Pomaglumetad methionil (LY2140023) is a high-affinity peptide transporter 1 (PEPT1) substrate with a Km value of ~30 µM[2].
LY2140023 is active against [14C]Gly-Sar with an IC50 value of 0.018 mM[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Pomaglumetad methionil (LY2140023; orally; 3-300 mg/kg; once daily for 7 days) dose-dependent increases the levels of the dopamine metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Fischer rats (approximately 250 g)[1]
Dosage: 3, 10, and 300 mg/kg
Administration: Orally; once daily for 7 days
Result: Dose-dependent increased the levels of the dopamine metabolites DOPAC and HVA.
Clinical Trial
Molecular Weight

366.41

Formula

C₁₂H₁₈N₂O₇S₂

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 13.33 mg/mL (36.38 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7292 mL 13.6459 mL 27.2918 mL
5 mM 0.5458 mL 2.7292 mL 5.4584 mL
10 mM 0.2729 mL 1.3646 mL 2.7292 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.33 mg/mL (3.63 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 1.33 mg/mL (3.63 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.33 mg/mL (3.63 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Pomaglumetad methionil anhydrous
Cat. No.:
HY-14554
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