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Cat. No.: HY-131286

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Talaglumetad

(Synonyms: LY-544344)

Talaglumetad (LY-544344) is an orally active prodrug of Eglumegad (HY-18941) and a metabotropic glutamate receptor 2/3 (mGluR2/3) agonist. Talaglumetad undergoes transmembrane transport via the intestinal peptide transporter hPepT1, and is enzymatically hydrolyzed to produce L-alanine and the parent drug Eglumegad after entering the body. Talaglumetad can be used in research related to metabotropic glutamate receptor 2-associated neurological systems.

For research use only. We do not sell to patients.

CAS No.: 441765-98-6
Formula: C₁₁H₁₆N₂O₅
Molecular Weight:256.26

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Talaglumetad Chemical Structure

CAS No.: 441765-98-6

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
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Biological Activity

Description

IC₅₀ & Target

mGluR2

mGluR3

All mGluR Isoforms :

In Vitro

Talaglumetad (LY-544344) functions as a substrate for the intestinal peptide transporter hPepT1 and is readily hydrolyzed by rat and human jejunum S9 fractions and plasma in vitro^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Talaglumetad (LY-544344) (p.o.) increases systemic exposure to the parent drug LY-354740 by up to 17-fold in healthy rats, with negligible prodrug levels in circulation^[2].
Talaglumetad (p.o.) increases systemic exposure to the parent drug LY-354740 by up to 16-fold in healthy dogs, with negligible prodrug levels in circulation and dose-proportional parent drug exposure^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 441765-98-6
Molecular Weight 256.26
Formula C₁₁H₁₆N₂O₅
SMILES

C[C@H](N)C(N[C@@]1([C@@]2([H])[C@](CC1)([H])[C@@H]2C(O)=O)C(O)=O)=O
Synonyms

LY-544344
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Vig B. Amino Acid Prodrugs for Oral Delivery: Challenges and Opportunities. Therapeutic Delivery. 2011 Aug 31;2(8):959-962.

[2]. Hu L, et al. Prodrugs: effective solutions for solubility, permeability and targeting challenges. IDrugs. 2004;7(8):736-742. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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- In Vitro
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Talaglumetad

All mGluR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Talaglumetad Related Classifications

HY-131286 Related Classifications