Talaglumetad  (Synonyms: LY-544344)

Talaglumetad (LY-544344) is an orally active prodrug of Eglumegad (HY-18941) and a metabotropic glutamate receptor 2/3 (mGluR2/3) agonist. Talaglumetad undergoes transmembrane transport via the intestinal peptide transporter hPepT1, and is enzymatically hydrolyzed to produce L-alanine and the parent drug Eglumegad after entering the body. Talaglumetad can be used in research related to metabotropic glutamate receptor 2-associated neurological systems^[1][2].

Talaglumetad (LY-544344) functions as a substrate for the intestinal peptide transporter hPepT1 and is readily hydrolyzed by rat and human jejunum S9 fractions and plasma in vitro^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Talaglumetad (LY-544344) (p.o.) increases systemic exposure to the parent drug LY-354740 by up to 17-fold in healthy rats, with negligible prodrug levels in circulation^[2].
Talaglumetad (p.o.) increases systemic exposure to the parent drug LY-354740 by up to 16-fold in healthy dogs, with negligible prodrug levels in circulation and dose-proportional parent drug exposure^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

256.26

C₁₁H₁₆N₂O₅

441765-98-6

C[C@H](N)C(N[C@@]1([C@@]2([H])[C@](CC1)([H])[C@@H]2C(O)=O)C(O)=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Vig B. Amino Acid Prodrugs for Oral Delivery: Challenges and Opportunities. Therapeutic Delivery. 2011 Aug 31;2(8):959-962.

  [2]. Hu L, et al. Prodrugs: effective solutions for solubility, permeability and targeting challenges. IDrugs. 2004;7(8):736-742.