1. GPCR/G Protein
    Neuronal Signaling
  2. mGluR
  3. JNJ-40411813

JNJ-40411813 (Synonyms: ADX-71149)

Cat. No.: HY-15748 Purity: 98.97%
Handling Instructions

JNJ-40411813 (ADX-71149) is a novel positive allosteric modulator of the metabotropic Glutamate 2 receptor (mGlu2R) with EC50 of 147 nM.

For research use only. We do not sell to patients.

JNJ-40411813 Chemical Structure

JNJ-40411813 Chemical Structure

CAS No. : 1127498-03-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 330 In-stock
Estimated Time of Arrival: December 31
5 mg USD 300 In-stock
Estimated Time of Arrival: December 31
10 mg USD 480 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1300 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2000 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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Description

JNJ-40411813 (ADX-71149) is a novel positive allosteric modulator of the metabotropic Glutamate 2 receptor (mGlu2R) with EC50 of 147 nM.

IC50 & Target[1]

mGlu2 Receptor

147 nM (EC50)

Clinical Trial
Molecular Weight

344.88

Formula

C₂₀H₂₅ClN₂O

CAS No.

1127498-03-6

SMILES

O=C1C(Cl)=C(N2CCC(C3=CC=CC=C3)CC2)C=CN1CCCC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (72.49 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8996 mL 14.4978 mL 28.9956 mL
5 mM 0.5799 mL 2.8996 mL 5.7991 mL
10 mM 0.2900 mL 1.4498 mL 2.8996 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (7.25 mM); Suspended solution; Need ultrasonic and warming

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.25 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: 2.5 mg/mL (7.25 mM); Clear solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

JNJ-40411813ADX-71149JNJ40411813JNJ 40411813ADX71149ADX 71149mGluRMetabotropic glutamate receptorsInhibitorinhibitorinhibit

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Product Name:
JNJ-40411813
Cat. No.:
HY-15748
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