1. GPCR/G Protein
  2. mGluR

JNJ-40411813 (Synonyms: ADX-71149)

Cat. No.: HY-15748 Purity: 99.69%
Data Sheet SDS Handling Instructions

JNJ-40411813 is a novel positive allosteric modulator of the metabotropic Glutamate 2 receptor (mGlu2R) with EC50 of 147 nM.

For research use only. We do not sell to patients.
JNJ-40411813 Chemical Structure

JNJ-40411813 Chemical Structure

CAS No. : 1127498-03-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO $379 In-stock
1 mg $180 In-stock
5 mg $500 In-stock
10 mg $750 In-stock
50 mg $2200 In-stock
100 mg $3500 In-stock
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

JNJ-40411813 is a novel positive allosteric modulator of the metabotropic Glutamate 2 receptor (mGlu2R) with EC50 of 147 nM. IC50 value: 147 nM(EC50) Target: mGlu2R JNJ-40411813 displayed an optimal interplay between potency, selectivity, favorable ADMET/PK and cardiovascular safety profile, and central EEG activity. JNJ-40411813 has been investigated in the clinic for schizophrenia and anxious depression disorders.

Clinical Trial
NCT Number Sponsor Condition Start Date Phase
NCT01358006 Johnson & Johnson Pharmaceutical Research & Development, L.L.C. Healthy November 2010 Phase 1
NCT01101659 Johnson & Johnson Pharmaceutical Research & Development, L.L.C. Perceptual Disorders|Confusion|Schizophrenia February 2010 Phase 1
NCT01582815 Janssen Research & Development, LLC Major Depressive Disorder September 2012 Phase 2
NCT01323205 Janssen Research & Development, LLC Schizophrenia May 2011 Phase 2
NCT01932320 Johnson & Johnson Pharmaceutical Research & Development, L.L.C. Healthy February 2010 Phase 1
NCT01932333 Johnson & Johnson Pharmaceutical Research & Development, L.L.C. Healthy May 2010 Phase 1
NCT01951053 Johnson & Johnson Pharmaceutical Research & Development, L.L.C. Healthy January 2010 Phase 1
NCT01359852 Johnson & Johnson Pharmaceutical Research & Development, L.L.C. Healthy December 2010 Phase 1
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References
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 2.8996 mL 14.4978 mL 28.9956 mL
5 mM 0.5799 mL 2.8996 mL 5.7991 mL
10 mM 0.2900 mL 1.4498 mL 2.8996 mL
References
Molecular Weight

344.88

Formula

C₂₀H₂₅ClN₂O

CAS No.

1127498-03-6

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
JNJ-40411813
Cat. No.:
HY-15748
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