1127498-03-6
1127498-03-6
Chemical Structure
JNJ-40411813
Synonym(s): ADX-71149
- CAS No.: 1127498-03-6
- Formula:C20H25ClN2O
- Molecular Weight:344.88
IUPAC Name: 1-butyl-3-chloro-4-(4-phenylpiperidin-1-yl)pyridin-2(1H)-one
InChIKey: HYOGJHCDLQSAHX-UHFFFAOYSA-N
SMILES: O=C1C(Cl)=C(N2CCC(C3=CC=CC=C3)CC2)C=CN1CCCC
Biological Activity: JNJ-40411813 (ADX-71149) is a novel positive allosteric modulator of the metabotropic Glutamate 2 receptor (mGlu2R) with EC50 of 147 nM. JNJ-40411813 has orally bioactivity and penetrate the blood-brain barriers. JNJ-40411813 has the potential property of anti-depression[1][2][3].
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JNJ-40411813 | 99.85% | JNJ-40411813 (ADX-71149) is a novel positive allosteric modulator of the metabotropic Glutamate 2 receptor (mGlu2R) with EC50 of 147 nM. JNJ-40411813 has orally bioactivity and penetrate the blood-brain barriers. JNJ-40411813 has the potential property of anti-depression. | ||||||||||||||||||||
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References
- [1]. Cid JM, et al. Discovery of 1-Butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): A Novel Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor. J Med Chem. 2014 Aug 14;57(15):6495-512. [Content Brief]
- [2]. Hilde Lavreysen, et al. Pharmacological and pharmacokinetic properties of JNJ-40411813, a positive allosteric modulator of the mGlu2 receptor. Pharmacol Res Perspect 2015 Feb;3(1):e00096. [Content Brief]
- [3]. Dunlop J, Schizophrenia, et al. Schizophrenia drug discovery and development in an evolving era: are new drug targets fulfilling expectations?. Journal of Psychopharmacology. 29 (2): 230–8. [Content Brief]
Keywords
