1. GPCR/G Protein
    Neuronal Signaling
  2. mGluR
  3. JNJ-46281222

JNJ-46281222 

Cat. No.: HY-120530 Purity: 98.79%
Handling Instructions

JNJ-46281222 is an metabotropic glutamate (mGlu) 2-selective, highly potent PAM (positive allosteric modulator) with nanomolar affinity (Kd = 1.7 nM) and a high modulatory potency (pEC50 = 7.71).

For research use only. We do not sell to patients.

JNJ-46281222 Chemical Structure

JNJ-46281222 Chemical Structure

CAS No. : 1254980-38-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 495 In-stock
Estimated Time of Arrival: December 31
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3850 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

JNJ-46281222 is an metabotropic glutamate (mGlu) 2-selective, highly potent PAM (positive allosteric modulator) with nanomolar affinity (Kd = 1.7 nM) and a high modulatory potency (pEC50 = 7.71)[1].

IC50 & Target[1]

mGluR2

1.7 nM (Kd)

In Vitro

JNJ‐4628122 binds to the selected mGlu2 receptor mutants is significantly decreased by approximately 10‐fold compared with WT, in transfected mGlu2 WT and mutant receptors in CHO‐K1 cells, mutations F643A and N735D are selected[1].

Western Blot Analysis[1]

Cell Line: CHO‐K1 cells
Concentration:
Incubation Time:
Result: Showed a decreased expression of mGlu2 receptor in mutant cells.
Molecular Weight

414.47

Formula

C₂₃H₂₅F₃N₄

CAS No.

1254980-38-5

SMILES

FC(C1=C(CN2CCC(C3=CC=CC=C3)CC2)C=CN4C1=NN=C4CC5CC5)(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (150.79 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4127 mL 12.0636 mL 24.1272 mL
5 mM 0.4825 mL 2.4127 mL 4.8254 mL
10 mM 0.2413 mL 1.2064 mL 2.4127 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.02 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.02 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

JNJ-46281222JNJ46281222JNJ 46281222mGluRMetabotropic glutamate receptorsPAM,Inhibitorinhibitorinhibit

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Product name:
JNJ-46281222
Cat. No.:
HY-120530
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