1. GPCR/G Protein
    Neuronal Signaling
  2. mGluR
  3. JNJ-46281222

JNJ-46281222 

Cat. No.: HY-120530
Handling Instructions

JNJ-46281222 is an metabotropic glutamate (mGlu) 2-selective, highly potent PAM (positive allosteric modulator) with nanomolar affinity (Kd = 1.7 nM) and a high modulatory potency (pEC50 = 7.71).

For research use only. We do not sell to patients.

JNJ-46281222 Chemical Structure

JNJ-46281222 Chemical Structure

CAS No. : 1254980-38-5

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Description

JNJ-46281222 is an metabotropic glutamate (mGlu) 2-selective, highly potent PAM (positive allosteric modulator) with nanomolar affinity (Kd = 1.7 nM) and a high modulatory potency (pEC50 = 7.71)[1].

IC50 & Target[1]

mGluR2

1.7 nM (Kd)

In Vitro

JNJ‐4628122 binds to the selected mGlu2 receptor mutants is significantly decreased by approximately 10‐fold compared with WT, in transfected mGlu2 WT and mutant receptors in CHO‐K1 cells, mutations F643A and N735D are selected[1].

Western Blot Analysis[1]

Cell Line: CHO‐K1 cells
Concentration:
Incubation Time:
Result: Showed a decreased expression of mGlu2 receptor in mutant cells.
Molecular Weight

414.47

Formula

C₂₃H₂₅F₃N₄

CAS No.

1254980-38-5

SMILES

FC(C1=C(CN2CCC(C3=CC=CC=C3)CC2)C=CN4C1=NN=C4CC5CC5)(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

JNJ-46281222JNJ46281222JNJ 46281222mGluRMetabotropic glutamate receptorsPAM,Inhibitorinhibitorinhibit

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