1254980-38-5
1254980-38-5
Chemical Structure
JNJ-46281222
- CAS No.: 1254980-38-5
- Formula:C23H25F3N4
- Molecular Weight:414.47
IUPAC Name: 3-(cyclopropylmethyl)-7-((4-phenylpiperidin-1-yl)methyl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine
InChIKey: LYDKDODJIBQNLK-UHFFFAOYSA-N
SMILES: FC(C1=C(CN2CCC(C3=CC=CC=C3)CC2)C=CN4C1=NN=C4CC5CC5)(F)F
Biological Activity: JNJ-46281222 is an metabotropic glutamate (mGlu) 2-selective, highly potent PAM (positive allosteric modulator) with nanomolar affinity (Kd = 1.7 nM) and a high modulatory potency (pEC50 = 7.71)[1].
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JNJ-46281222 | 98.77% | JNJ-46281222 is an metabotropic glutamate (mGlu) 2-selective, highly potent PAM (positive allosteric modulator) with nanomolar affinity (Kd = 1.7 nM) and a high modulatory potency (pEC50 = 7.71). | ||||||||||||||||||||
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