2009052-76-8
Chemical Structure
VU6001966
- CAS No.: 2009052-76-8
- Formula:C17H15FN4O2
- Molecular Weight:326.33
IUPAC Name: 4-(4-fluorophenyl)-5-((1-methyl-1H-pyrazol-3-yl)methoxy)picolinamide
InChIKey: SSSNPJKQBYVHBV-UHFFFAOYSA-N
SMILES: O=C(C1=NC=C(OCC2=NN(C)C=C2)C(C3=CC=C(F)C=C3)=C1)N
Biological Activity: VU6001966 is a brain-penetrant and selective mGlu2 receptor inhibitor. VU6001966 blocks mGlu2 receptor activity, counteracts LY379268 (HY-103558)-mediated blood-brain barrier protection and inflammatory cytokine dampening in microglia under inflammatory conditions. VU6001966 enhances antidepressant effects when combined with Scopolamine (HY-N0296). VU6001966 can be used for the research of major depressive disorder[1][2][3][4].
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VU6001966 | 99.89% | VU6001966 is a brain-penetrant and selective mGlu2 receptor inhibitor. VU6001966 blocks mGlu2 receptor activity, counteracts LY379268 (HY-103558)-mediated blood-brain barrier protection and inflammatory cytokine dampening in microglia under inflammatory conditions. VU6001966 enhances antidepressant effects when combined with Scopolamine (HY-N0296). VU6001966 can be used for the research of major depressive disorder. | ||||||||||||||||||||
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- [1]. Costantino G, et al. Group II metabotropic glutamate receptors modulate blood brain barrier function: direct and indirect effect through astrocytes and microglia. Eur J Pharmacol. 2025 Sep 15;1003:177893. [Content Brief]
- [2]. Babii Y, et al. Coadministration of scopolamine and mGlu2 NAM VU6001966 as a novel antidepressant approach: Lowering effective dose and reducing cognitive side effects. Psychopharmacology (Berl). Published online October 13, 2025. [Content Brief]
- [3]. Babii Y, et al. Coadministration of scopolamine and mGlu2 receptor negative allosteric modulator VU6001966 as a potential therapeutic approach for depression: Rat frontal cortex neurochemistry and behavior. Pharmacol Biochem Behav. 2025 May;250:173996. [Content Brief]
- [4]. Bollinger KA, et al. Design and Synthesis of mGlu2 NAMs with Improved Potency and CNS Penetration Based on a Truncated Picolinamide Core. ACS Med Chem Lett. 2017;8(9):919-924. Published 2017 Aug 3. [Content Brief]
Keywords
