1. GPCR/G Protein
    Neuronal Signaling
  2. mGluR
  3. Decoglurant

Decoglurant (Synonyms: RO4995819)

Cat. No.: HY-16766 Purity: 99.71%
Handling Instructions

Decoglurant (RO4995819) is a negative allosteric modulator of mGluR2 and mGluR3. Decoglurant is developed as an antidepressant.

For research use only. We do not sell to patients.

Decoglurant Chemical Structure

Decoglurant Chemical Structure

CAS No. : 911115-16-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 495 In-stock
Estimated Time of Arrival: December 31
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2100 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2950 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Decoglurant (RO4995819) is a negative allosteric modulator of mGluR2 and mGluR3. Decoglurant is developed as an antidepressant[1].

IC50 & Target[1]

mGluR2

 

mGluR3

 

Clinical Trial
Molecular Weight

447.34

Formula

C₂₁H₁₁F₆N₅

CAS No.

911115-16-7

SMILES

NC1=NC=C(C#CC2=C3N=C(C4=CC=C(C(F)(F)F)C=C4)C=C(C(F)(F)F)N3N=C2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (558.86 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2354 mL 11.1772 mL 22.3544 mL
5 mM 0.4471 mL 2.2354 mL 4.4709 mL
10 mM 0.2235 mL 1.1177 mL 2.2354 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.65 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

DecoglurantRO4995819RO 4995819RO-4995819mGluRMetabotropic glutamate receptorsmGluR2mGluR3NAMantidepressantInhibitorinhibitorinhibit

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Product Name:
Decoglurant
Cat. No.:
HY-16766
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