1. Metabolic Enzyme/Protease
  2. E1/E2/E3 Enzyme
  3. ML-792


Cat. No.: HY-108702 Purity: 99.90%
COA Handling Instructions

ML-792 is a potent and selective inhibitor of SAE/SUMO1 and SAE/SUMO2 in enzymatic assays (IC50 values of 3 and 11 nM, respectively) compared with NAE/NEDD8 and UAE/ubiquitin (IC50> values of 32 μM and >100 μM, respectively).

For research use only. We do not sell to patients.

ML-792 Chemical Structure

ML-792 Chemical Structure

CAS No. : 1644342-14-2

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 303 In-stock
10 mM * 1 mL in DMSO USD 303 In-stock
5 mg USD 250 In-stock
10 mg USD 350 In-stock
25 mg USD 550 In-stock
50 mg USD 750 In-stock
100 mg USD 1250 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 22 publication(s) in Google Scholar

Top Publications Citing Use of Products

    ML-792 purchased from MedChemExpress. Usage Cited in: Mol Cell. 2020 Jul 2;79(1):54-67.e7.  [Abstract]

    Treatment of cells with the SUMO inhibitor ML-792 for 4 or 24 h causes a dramatic recruitment of FUSP525L in G3BP1-positive SGs. By contrast, wild-type FUS does not accumulate in these structures upon inhibition of SUMOylation.
    • Biological Activity

    • Purity & Documentation

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    • Customer Review


    ML-792 is a potent and selective inhibitor of SAE/SUMO1 and SAE/SUMO2 in enzymatic assays (IC50 values of 3 and 11 nM, respectively) compared with NAE/NEDD8 and UAE/ubiquitin (IC50> values of 32 μM and >100 μM, respectively)[1].

    IC50 & Target

    IC50: 3 nM (SAE/SUMO1), 11 nM (SAE/SUMO2)[1]

    In Vitro

    ML-792 (0.0007-5 μM; 4 hours) inhibits SAE and SUMO-pathway activities in HCT116 cells[1].
    ML-792 (0.001-10 μM; 72 hours ) inhibits cell proliferation and decreases cancer cell viability in MDA-MB-468, MDA-MB-231, HCT116, Colo-205, and A375[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Viability Assay[1]

    Cell Line: Human breast cancer cells MDA-MB-468 and MDA-MB-231; human colon carcinoma cells HCT116 and Colo-205; human melanoma cell line A375
    Concentration: 0.001, 0.01, 0.1, 1, 10 μM
    Incubation Time: 72 hours
    Result: Demonstrated a dose-dependent viability effect with EC50 values of 0.06 μM in MDA-MB-468 cells to 0.45 μM in A375 cells.

    Western Blot Analysis[1]

    Cell Line: HCT116 cells
    Concentration: 0, 0.0007, 0.002, 0.007, 0.02, 0.06, 0.19, 0.56, 1.7, 5 μM
    Incubation Time: 4 hours
    Result: Revealed a dose-dependent decrease in the SAE and UBC9 thioester levels.
    Molecular Weight




    CAS No.



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    Room temperature in continental US; may vary elsewhere.

    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (181.35 mM; Need ultrasonic)

    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.8135 mL 9.0677 mL 18.1353 mL
    5 mM 0.3627 mL 1.8135 mL 3.6271 mL
    10 mM 0.1814 mL 0.9068 mL 1.8135 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.08 mg/mL (3.77 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.08 mg/mL (3.77 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 2.08 mg/mL (3.77 mM); Clear solution

    *All of the co-solvents are available by MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.90%

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    ML-792 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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