1. Metabolic Enzyme/Protease
  2. E1/E2/E3 Enzyme
  3. ML-792

ML-792 

Cat. No.: HY-108702
Handling Instructions

ML-792 is a specific small ubiquitin-like modifier (SUMO)-activating enzyme (SAE) inhibitor. ML-792 is a potent and selective inhibitor of SAE/SUMO1 and SAE/SUMO2 in enzymatic assays (IC50s of 3 and 11 nM, respectively) compared with NAE/NEDD8 and UAE/ubiquitin (IC50s of 32 μM and >100 μM, respectively).

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ML-792 Chemical Structure

ML-792 Chemical Structure

CAS No. : 1644342-14-2

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Description

ML-792 is a specific small ubiquitin-like modifier (SUMO)-activating enzyme (SAE) inhibitor. ML-792 is a potent and selective inhibitor of SAE/SUMO1 and SAE/SUMO2 in enzymatic assays (IC50s of 3 and 11 nM, respectively) compared with NAE/NEDD8 and UAE/ubiquitin (IC50s of 32 μM and >100 μM, respectively)[1].

Molecular Weight

551.41

Formula

C₂₁H₂₃BrN₆O₅S

CAS No.

1644342-14-2

SMILES

O=S(OC[[email protected]@H]1[[email protected]@H](O)C[[email protected]](NC2=NC=NC=C2C(C3=NN(CC4=CC=CC(Br)=C4)C=C3)=O)C1)(N)=O

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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ML-792
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