1644342-14-2
1644342-14-2
Chemical Structure
ML-792
- CAS No.: 1644342-14-2
- Formula:C21H23BrN6O5S
- Molecular Weight:551.41
IUPAC Name: ((1R,2S,4R)-4-((5-(1-(3-bromobenzyl)-1H-pyrazole-3-carbonyl)pyrimidin-4-yl)amino)-2-hydroxycyclopentyl)methyl sulfamate
InChIKey: PZCKLTWSXFDLLP-OGWOLHLISA-N
SMILES: O=S(OC[C@@H]1[C@@H](O)C[C@H](NC2=NC=NC=C2C(C3=NN(CC4=CC=CC(Br)=C4)C=C3)=O)C1)(N)=O
Biological Activity: ML-792 is a potent and selective inhibitor of SAE/SUMO1 and SAE/SUMO2 in enzymatic assays (IC50 values of 3 and 11 nM, respectively) compared with NAE/NEDD8 and UAE/ubiquitin (IC50> values of 32 μM and >100 μM, respectively)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ML-792 | 99.76% | ML-792 is a potent and selective inhibitor of SAE/SUMO1 and SAE/SUMO2 in enzymatic assays (IC50 values of 3 and 11 nM, respectively) compared with NAE/NEDD8 and UAE/ubiquitin (IC50> values of 32 μM and >100 μM, respectively). | ||||||||||||||||||||
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ML-792 (Standard) | ≥98% | ML-792 (Standard) is the analytical standard of ML-792 (HY-108702). This product is intended for research and analytical applications. ML-792 is a potent and selective inhibitor of SAE/SUMO1 and SAE/SUMO2 in enzymatic assays (IC50 values of 3 and 11 nM, respectively) compared with NAE/NEDD8 and UAE/ubiquitin (IC50> values of 32 μM and >100 μM, respectively). | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.57
HY-111789Subasumstat -
Similarity Score 0.57
HY-111789A(S)-Subasumstat -
Similarity Score 0.57
HY-176907ML-93 -
Similarity Score 0.49
HY-10484RPevonedistat hydrochloride (Standard) -
Similarity Score 0.49
HY-70062RPevonedistat (Standard) -
Similarity Score 0.49
HY-162230PRMT5-IN-33 -
Similarity Score 0.48
HY-100487RTAK-243 (Standard) -
Similarity Score 0.45
HY-15798UNC2881 -
Similarity Score 0.43
HY-156340Anti-inflammatory agent 58 -
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