1. Metabolic Enzyme/Protease
  2. E1/E2/E3 Enzyme

COH000 

Cat. No.: HY-114304
Handling Instructions

COH000 is an inhibitor of Ubiquitin-like 1-activating enzyme (SUMO-activating enzyme), with an IC50 of 0.2 μM for SUMOylation in vitro.

For research use only. We do not sell to patients.

COH000 Chemical Structure

COH000 Chemical Structure

CAS No. : 1534358-79-6

Size Stock
250 mg Get quote
500 mg Get quote

* Please select Quantity before adding items.

Customer Review

  • Biological Activity

  • Technical Information

  • References

Description

COH000 is an inhibitor of Ubiquitin-like 1-activating enzyme (SUMO-activating enzyme), with an IC50 of 0.2 μM for SUMOylation in vitro[1].

IC50 & Target

IC50: 0.2 μM (SUMO-activating enzyme)[1].

In Vitro

COH000 has over 500-fold selectivity for SUMOylation than ubiquitylation. COH000 inhibits SUMO adenylation without directly competing with ATP or SUMO1 binding. COH000 has an extremely slow off-rate and is consistent with it being covalently bound to the enzyme[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3840 mL 11.9198 mL 23.8396 mL
5 mM 0.4768 mL 2.3840 mL 4.7679 mL
10 mM 0.2384 mL 1.1920 mL 2.3840 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

419.47

Formula

C₂₅H₂₅NO₅

CAS No.

1534358-79-6

SMILES

CC(C=C1)=CC=C1C[[email protected]@H](NC2=CC=CC=C2)[[email protected]]34C(C(OC)=O)=C(C(OC)=O)[[email protected]@H](O4)C=C3

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
COH000
Cat. No.:
HY-114304
Quantity:

COH000

Cat. No.: HY-114304