1. Metabolic Enzyme/Protease
  2. E1/E2/E3 Enzyme
  3. COH000

COH000 

Cat. No.: HY-114304 Purity: >98.0%
Handling Instructions

COH000 is an allosteric, covalent and irreversible inhibitor of ubiquitin-like 1-activating enzyme (SUMO-activating enzyme) (E1), with an IC50 of 0.2 μM for SUMOylation in vitro.

For research use only. We do not sell to patients.

COH000 Chemical Structure

COH000 Chemical Structure

CAS No. : 1534358-79-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 715 In-stock
Estimated Time of Arrival: December 31
5 mg USD 650 In-stock
Estimated Time of Arrival: December 31
10 mg USD 850 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2400 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3400 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

COH000 is an allosteric, covalent and irreversible inhibitor of ubiquitin-like 1-activating enzyme (SUMO-activating enzyme) (E1), with an IC50 of 0.2 μM for SUMOylation in vitro[1].

IC50 & Target

IC50: 0.2 μM (SUMO-activating enzyme)[1].

In Vitro

COH000 has over 500-fold selectivity for SUMOylation than ubiquitylation. COH000 inhibits SUMO adenylation without directly competing with ATP or SUMO1 binding. COH000 has an extremely slow off-rate and is consistent with it being covalently bound to the enzyme[1].

Molecular Weight

419.47

Formula

C₂₅H₂₅NO₅

CAS No.

1534358-79-6

SMILES

CC(C=C1)=CC=C1C[[email protected]@H](NC2=CC=CC=C2)[[email protected]]34C(C(OC)=O)=C(C(OC)=O)[[email protected]@H](O4)C=C3

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 35.71 mg/mL (85.13 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3840 mL 11.9198 mL 23.8396 mL
5 mM 0.4768 mL 2.3840 mL 4.7679 mL
10 mM 0.2384 mL 1.1920 mL 2.3840 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Product Name:
COH000
Cat. No.:
HY-114304
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