PSIP1 - PC4 and SRSF1 interacting protein 1 Gene

Also Known as p52; p75; PAIP; DFS70; LEDGF; PSIP2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 11168

About PSIP1

Cytogenetic location: 9p22.3 Genomic coordinates (GRCh38): 9:15,464,066-15,510,970 (from NCBI)

This gene has 11 transcripts (splice variants), 255 orthologues, 4 paralogues and is associated with 66 phenotypes. Ubiquitous expression in brain (RPKM 41.2), ovary (RPKM 33.4) and 24 other tissues.

Summary

Enables DNA-binding transcription factor binding activity; chromatin binding activity; and transcription coactivator activity. Involved in mRNA 5'-splice site recognition and positive regulation of transcription by RNA polymerase II. Located in heterochromatin; nuclear periphery; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PSIP1 Products (5)

mRNA	Protein	Name
NM_001128217.3	NP_001121689.1	PC4 and SFRS1-interacting protein isoform 2
NM_001317898.3	NP_001304827.1	PC4 and SFRS1-interacting protein isoform 3
NM_001317900.3	NP_001304829.1	PC4 and SFRS1-interacting protein isoform 4
NM_021144.4	NP_066967.3	PC4 and SFRS1-interacting protein isoform 1
NM_033222.5	NP_150091.2	PC4 and SFRS1-interacting protein isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor binding	IDA IDA: Inferred from direct assay	9822615	GOA
enables chromatin binding	IDA IDA: Inferred from direct assay	20974633	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9885563	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	9822615	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in mRNA 5'-splice site recognition	IDA IDA: Inferred from direct assay	9885563	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9822615	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in heterochromatin	IDA IDA: Inferred from direct assay	12796494	GOA
located in nuclear periphery	IDA IDA: Inferred from direct assay	11512661	GOA
NOT located in nucleolus	IDA IDA: Inferred from direct assay	11512661	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	9885563	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12796494	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSIP1 Protein Structure

PWWP

LEDGF

0
100
200
300
400
500
530 a.a.

Protein Preferred Names	Protein Names
PC4 and SFRS1-interacting protein	CLL-associated antigen KW-7

PSIP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PSIP1	O75475	RBBP8	Homo sapiens	Q99708	Anti Tag CoIP	22773103
Intra	PSIP1	O75475	RBBP8	Homo sapiens	Q99708	Anti Bait CoIP	22773103
Cross	PSIP1	O75475	gag-pol	Human immunodeficiency virus	P04585	ELISA	21156026

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PSIP1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P79208	LEDGF p52 Protein, Human	O75475-2/NP_066967 (M1-Q333)	≥ 95%, as determined by reducing SDS-PAGE.

PSIP1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83862	PSIP1/LEDGF Antibody (YA3559)	WB, IHC-P, ICC/IF, ELISA	Human, Rat, Monkey
HY-P83862A	PSIP1/LEDGF Antibody (YA3559)(PBS only)	WB, IHC-P, ICC/IF, ELISA	Human, Rat, Monkey
HY-P85256	PSIP1/LEDGF Antibody (YA4948)	WB; IHC-P; IHC-F; ICC/IF; IF-Tissue	Human

Related Diseases

Diseases	Alias
Olfactory Neuroblastoma	Esthesioneuroblastoma Asthesioneuroblastoma Esthesioneuroepithelioma Olfactory Esthesioneuroblastoma Paranasal Sinus Olfactory Neuroblastoma Esthesioneuroblastoma, Olfactory Esthesioneuroblastoma Of Nasal Cavity
Interstitial Cystitis	Bladder Pain Syndrome Painful Bladder Syndrome Ulcerative Cystitis Ic/Bps Ic/Pbs Interstitial Cystitis/Bladder Pain Syndrome Interstitial Cystitis/Painful Bladder Syndrome Cystitis, Interstitial Chronic Interstitial Cystitis Pelvic Congestion Syndrome Trigonitis
Laryngeal Small Cell Carcinoma	Small Cell Carcinoma Of Larynx
Dermatitis, Atopic	Atopic Dermatitis Atopic Eczema Dermatitis, Atopic, Susceptibility To, 1 Atod Eczema, Atopic Dermatitis, Atopic 1 Allergic Dermatitis Atopic Neurodermatitis Besnier'S Prurigo Dermatitis, Atopic, 1 Dermatitis Atopic Eczema Besnier Prurigo
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Cataract	Cataracts Cat - [Cataract] Cataract Form Lens Opacity Lens Opacities
Granulomatous Disease, Chronic, X-Linked	CGDX Chronic Granulomatous Disease, X-Linked X-Linked Chronic Granulomatous Disease Cgd Cytochrome B-Negative Granulomatous Disease, Chronic, X-Linked Cdgx X-Linked Chronic Cytochrome B-Negative Granulomatous Disease Chronic Granulomatous Disease Cytochrome B-Negative X-Linked Chronic Granulomatous Disease Cytochrome B-Positive X-Linked Granulomatous Disease, Chronic, X-Linked, Variant
Retinal Degeneration	Degeneration Of Retina
Multiple Endocrine Neoplasia, Type I	Multiple Endocrine Neoplasia Type 1 MEN1 Wermer Syndrome Multiple Endocrine Neoplasia 1 Multiple Endocrine Neoplasia, Type 1 Men I Endocrine Adenomatosis, Multiple Mea I Men Type I Wermer'S Syndrome Men1 Syndrome Multiple Endocrine Adenomatosis Endocrine Adenomatosis Multiple Men 1 Familial Multiple Endocrine Neoplasia Type I Neoplasia, Endocrine, Multiple, Type 1 Multiple Endocrine Neoplasia
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18601	(±)-BI-D	Inhibitor	98.06%	Unkown
HY-W023758	HDGFRP2/PSIP1-IN-1		99.50%	Unkown
HY-RS11289	PSIP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22744	Psip1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PSIP1	VGNC	VGNC:76437
Mus musculus	PSIP1	MGD	MGI:2142116
Rattus norvegicus	PSIP1	RGD	RGD:631439
Canis familiaris	PSIP1	VGNC	VGNC:45087
Felis catus	PSIP1	VGNC	VGNC:69103
Bos taurus	PSIP1	VGNC	VGNC:33436
Others	PSIP1	NCBI