1. Anti-infection
    Metabolic Enzyme/Protease
  2. HIV
    HIV Integrase

(±)-BI-D 

Cat. No.: HY-18601 Purity: 95.66%
Handling Instructions

(±)-BI-D is a potent ALLINI(An allosteric IN inhibitor) that binds integrase at the LEDGF/p75 binding site.

For research use only. We do not sell to patients.

(±)-BI-D Chemical Structure

(±)-BI-D Chemical Structure

CAS No. : 1416258-16-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 462 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2520 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products

    (±)-BI-D purchased from MCE. Usage Cited in: Cell Host Microbe. 2018 Sep 12;24(3):392-404.e8.

    Representative MICDDRP images (scale bar, 5 µm), with quantitative assessment of 196 to 284 foci shown to the right for n=2 independent experiments, each conducted in duplicate.
    • Biological Activity

    • Technical Information

    • Purity & Documentation

    • References

    Description

    (±)-BI-D is a potent ALLINI(An allosteric IN inhibitor) that binds integrase at the LEDGF/p75 binding site. IC50 value: 2.4–2.9 μM(HIV-Luc infection of WT and Hdgfrp2 KO cells) [1] Target: integrase inhibitor in vitro: Approximately 2.4–2.9 μM of BI-D was required to inhibit 50% of HIV-Luc infection of WT and Hdgfrp2 KO cells, while the IC50 decreased dramatically, to 160–200 nM, in Psip1 and double-KO cells [1].

    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (246.62 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.4662 mL 12.3308 mL 24.6615 mL
    5 mM 0.4932 mL 2.4662 mL 4.9323 mL
    10 mM 0.2466 mL 1.2331 mL 2.4662 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (6.17 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (6.17 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (6.17 mM); Clear solution

    References
    Molecular Weight

    405.49

    Formula

    C₂₅H₂₇NO₄

    CAS No.

    1416258-16-6

    SMILES

    OC(C(OC(C)(C)C)C1=C(C(C=CC=C2)=C2N=C1C)C3=CC(CCCO4)=C4C=C3)=O

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

    • Molarity Calculator

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    × = ×
    C1   V1   C2   V2

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    Product Name:
    (±)-BI-D
    Cat. No.:
    HY-18601
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    (±)-BI-D

    Cat. No.: HY-18601