1416258-16-6
1416258-16-6
Chemical Structure
(±)-BI-D
- CAS No.: 1416258-16-6
- Formula:C25H27NO4
- Molecular Weight:405.49
IUPAC Name: 2-(tert-butoxy)-2-(4-(chroman-6-yl)-2-methylquinolin-3-yl)acetic acid
InChIKey: ZFERZAMPQIXCPM-UHFFFAOYSA-N
SMILES: OC(C(OC(C)(C)C)C1=C(C(C=CC=C2)=C2N=C1C)C3=CC(CCCO4)=C4C=C3)=O
Biological Activity: (±)-BI-D is a potent ALLINI (allosteric integrase inhibitor). (±)-BI-D binds integrase at the LEDGF/p75 binding site. (±)-BI-D inhibits HIV-Luc infection in cells (IC50: 0.16 μM in Psip1 knockout E9 mouse embryonic fibroblasts, 2.9 μM in wild-type E9 mouse embryonic fibroblasts)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(±)-BI-D | 98.06% | (±)-BI-D is a potent ALLINI (allosteric integrase inhibitor). (±)-BI-D binds integrase at the LEDGF/p75 binding site. (±)-BI-D inhibits HIV-Luc infection in cells (IC50: 0.16 μM in Psip1 knockout E9 mouse embryonic fibroblasts, 2.9 μM in wild-type E9 mouse embryonic fibroblasts). | ||||||||||||||||||||
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References
- [1]. Wang H, et al. HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor. Nucleic Acids Res. 2012 Dec;40(22):11518-30. [Content Brief]
- [2]. Fader LD, et al. Minimizing the Contribution of Enterohepatic Recirculation to Clearance in Rat for the NCINI Class of Inhibitors of HIV. ACS Med Chem Lett. 2014 Apr 16;5(6):711-6. [Content Brief]
Keywords
