RANGAP1 - Ran GTPase activating protein 1 Gene

Also Known as SD; Fug1; RANGAP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5905

About RANGAP1

Cytogenetic location: 22q13.2 Genomic coordinates (GRCh38): 22:41,244,779-41,302,369 (from NCBI)

This gene has 8 transcripts (splice variants) and 282 orthologues. Broad expression in testis (RPKM 19.7), skin (RPKM 13.7) and 25 other tissues.

Summary

This gene encodes a protein that associates with the nuclear pore complex and participates in the regulation of nuclear transport. The encoded protein interacts with Ras-related nuclear protein 1 (RAN) and regulates guanosine triphosphate (GTP)-binding and exchange. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

RANGAP1 Products (3)

mRNA Protein Name
NM_001278651.2 NP_001265580.1 ran GTPase-activating protein 1
NM_001317930.2 NP_001304859.1 ran GTPase-activating protein 1
NM_002883.4 NP_002874.1 ran GTPase-activating protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase activator activity IDA
IDA: Inferred from direct assay
16428860 GOA
enables RNA binding IDA
IDA: Inferred from direct assay
26308891 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
14729961 GOA
enables small GTPase binding IPI
IPI: Inferred from physical interaction
16428860 GOA
Biological Process GO Annotation Evidence References Source
involved in activation of GTPase activity IDA
IDA: Inferred from direct assay
16428860 GOA
involved in negative regulation of protein export from nucleus IDA
IDA: Inferred from direct assay
16449645 GOA
involved in nuclear export EXP
EXP: Inferred from Experiment
27160050 GOA
involved in protein sumoylation IDA
IDA: Inferred from direct assay
22194619 GOA
Cellular Component GO Annotation Evidence References Source
part of SUMO ligase complex IPI
IPI: Inferred from physical interaction
22194619 GOA
colocalizes with kinetochore IDA
IDA: Inferred from direct assay
17363900 GOA
located in nuclear envelope IDA
IDA: Inferred from direct assay
25468996 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
26308891 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RANGAP1 Protein Structure

LRR_6

LRR_6: Leucine Rich repeat (113 - 132)

LRR_6

LRR_6: Leucine Rich repeat (236 - 257)

LRR_6

LRR_6: Leucine Rich repeat (292 - 312)

LRR_6

LRR_6: Leucine Rich repeat (323 - 342)

RanGAP1_C

RanGAP1_C: RanGAP1 C-terminal domain (404 - 586)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 587 a.a.
Protein Preferred Names Protein Names

ran GTPase-activating protein 1

  • segregation distorter homolog

RANGAP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RANGAP1 P46060 SUMO1 Homo sapiens P63165
Anti Bait CoIP
23395904
Intra
RANGAP1 P46060 SUMO1 Homo sapiens P63165
X-Ray Diffraction
22194619
Intra
RANGAP1 P46060 SUMO1 Homo sapiens P63165
Anti Tag CoIP
17036045
Intra
RANGAP1 P46060 SUMO1 Homo sapiens P63165
Anti Bait CoIP
17000644
Intra
RANGAP1 P46060 SUMO1 Homo sapiens P63165
ITC
17099698
Intra
RANGAP1 P46060 SUMO1 Homo sapiens P63165
X-Ray Diffraction
17099698
Intra
RANGAP1 P46060 SUMO1 Homo sapiens P63165
Comigration in SDS
20414307
Intra
RANGAP1 P46060 SUMO1 Homo sapiens P63165
Comigration in SDS
16732283
Intra
RANGAP1 P46060 SUMO1 Homo sapiens P63165
X-Ray Diffraction
17099700
Intra
RANGAP1 P46060 SUMO1 Homo sapiens P63165
GMS
17099700
Intra
RANGAP1 P46060 UBE2I Homo sapiens P63279
Pull Down
23395904
Intra
RANGAP1 P46060 UBE2I Homo sapiens P63279
X-Ray Diffraction
22194619
Intra
RANGAP1 P46060 UBE2I Homo sapiens P63279
Y2H
21988832
Intra
RANGAP1 P46060 RANBP2 Homo sapiens P49792
X-Ray Diffraction
22194619
Cross: Cross-species interaction Intra: Intraspecies interaction

RANGAP1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82155 RanGAP1 Antibody (YA1900) WB, IHC-P, ICC/IF, FC, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Parkinson Disease 7, Autosomal Recessive Early-Onset

  • Autosomal Recessive Early-Onset Parkinson Disease 7

  • PARK7

  • Parkinson'S Disease 7

  • Autosomal Recessive Early-Onset Parkinson'S Disease 7

  • Parkinson Disease 7

  • Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex Type 2

  • Autosomal Recessive Early-Onset Parkinson Disease Type 7

  • Parkinson Disease, Type 7
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1

  • FTDALS1

  • Frontotemporal Dementia And/Or Motor Neuron Disease

  • Ftdmnd

  • Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia

  • Alsftd

  • Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis

  • Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-1

  • Frontotemporal Dementia With Motor Neuron Disease

  • Ftdals

  • Ftd-Als

  • Ftd-Mnd

  • Frontotemporal Dementia With Amyotrophic Lateral Sclerosis

  • Amyotrophic Lateral Sclerosis With Frontotemporal Dementia 1

  • Amyotrophic Lateral Sclerosis/Frontotemporal Dementia

  • Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis

  • Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia 1

  • Frontotemporal Lobar Degeneration

  • Grn-Related Frontotemporal Dementia
Amyotrophic Lateral Sclerosis 1

  • Amyotrophic Lateral Sclerosis

  • ALS

  • Lou Gehrig Disease

  • Amyotrophic Lateral Sclerosis Type 1

  • Charcot Disease

  • ALS1

  • Amyotrophic Lateral Sclerosis, Susceptibility To

  • Fals

  • Lou Gehrig'S Disease

  • Mnd

  • Motor Neuron Disease

  • Familial Amyotrophic Lateral Sclerosis

  • Amyotrophic Lateral Sclerosis 1, Familial

  • Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

  • Motor Neuron Disease, Bulbar

  • Motor Neurone Disease

  • Amyotrophic Lateral Sclerosis With Dementia

  • Dementia With Amyotrophic Lateral Sclerosis

  • Motor Neuron Disease, Amyotrophic Lateral Sclerosis

  • Sclerosis, Lateral, Amyotrophic

  • Sclerosis, Lateral, Amyotrophic, Type 1

  • Amyotrophic Sclerosis

  • Als - [Amyotrophic Lateral Sclerosis]

  • Wasting Palsy

  • Amyotrophic Paralysis

  • Amyotrophy Lateral Sclerosis

  • Wasting Paralysis

  • Spinal Progressive Amyotrophy

  • Progressive Atrophic Paralysis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11650 RANGAP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-123888 Viomellein Inhibitor / Unkown
HY-181772 MCULE-3064932370 Inhibitor / Unkown
HY-RS22022 Rangap1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28540 Rangap1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta RANGAP1 VGNC VGNC:76656
Felis catus RANGAP1 VGNC VGNC:69235
Mus musculus RANGAP1 MGD MGI:103071
Canis familiaris RANGAP1 VGNC VGNC:45340
Bos taurus RANGAP1 VGNC VGNC:33713
Rattus norvegicus RANGAP1 RGD RGD:1310380
Others RANGAP1 NCBI