Viomellein
Viomellein is a SUMOylation inhibitor with antibacterial and anticancer activities. Viomellein inhibits biofilm formation of strains produced from the fungus Aspergillus ochraceus from the Mediterranean sponge Agelas oroides. Viomellein exhibits cytotoxicity against A2780 human ovarian cancer cells with an IC50 value of 5.0 μM. Viomellein also inhibits SUMOylation of RanGAP1 (GTPase activating protein) with an IC50 of 10.2 μM.
For research use only. We do not sell to patients.
- CAS No.: 55625-78-0
- Formula: C30H24O11
- Molecular Weight:560.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 55625-78-0
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Molecular Weight 560.50
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Formula C30H24O11
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SMILES
O=C1C2=C(O)C3=C(C(C(OC)=C(C4=C(OC)C=C5C=C(C[C@@H](C)O6)C(C6=O)=C(O)C5=C4O)C3=O)=O)C=C2C[C@@H](C)O1
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Structure Classification
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Initial Source
Aspergillus ochraceus
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Kumla D, et al. 1,3-Dioxepine and spiropyran derivatives of viomellein and other dimeric naphthopyranones from cultures of Aspergillus elegans KUFA0015 and their antibacterial activity. Phytochemistry. 2021 Jan;181:112575 [Content Brief]
[2]. Hirohama M, et al. Spectomycin B1 as a novel SUMOylation inhibitor that directly binds to SUMO E2. ACS Chem Biol. 2013 Dec 20;8(12):2635-42. [Content Brief]
[3]. Cryptic Secondary Metabolites from the Sponge-Associated Fungus Aspergillus ochraceus
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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