SART1 - spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP Gene

Also Known as HAF; Ara1; HOMS1; Snu66; SART1259; SNRNP110

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9092

About SART1

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:65,961,734-65,980,137 (from NCBI)

Ubiquitous expression in bone marrow (RPKM 16.1), spleen (RPKM 14.5) and 25 other tissues.

Summary

This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in Cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for Cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway. [provided by RefSeq, Jul 2008]

SART1 Products (1)

mRNA Protein Name
NM_005146.5 NP_005137.1 U4/U6.U5 tri-snRNP-associated protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15620657 GOA
Biological Process GO Annotation Evidence References Source
involved in mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
28781166 GOA
involved in positive regulation of cytotoxic T cell differentiation IDA
IDA: Inferred from direct assay
10209962 GOA
Cellular Component GO Annotation Evidence References Source
located in Cajal body IDA
IDA: Inferred from direct assay
16687569 GOA
part of U2-type precatalytic spliceosome IDA
IDA: Inferred from direct assay
28781166 GOA
part of U4/U6 x U5 tri-snRNP complex IPI
IPI: Inferred from physical interaction
30975767 GOA
part of catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
11991638 GOA
located in nucleoplasm IDA
IDA: Inferred from direct assay
16687569 GOA
located in nucleus IDA
IDA: Inferred from direct assay
28781166 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SART1 Protein Structure

SART-1

SART-1: SART-1 family (117 - 753)

  • 0
  • 200
  • 400
  • 600
  • 800 a.a.
Protein Preferred Names Protein Names

U4/U6.U5 tri-snRNP-associated protein 1

  • IgE autoantigen

SART1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SART1 O43290 SNRNP200 Homo sapiens O75643
Anti Bait CoIP
16723661
Intra
SART1 O43290 SUMO3 Homo sapiens P55854
Affinity Chrom
17000644
Intra
SART1 O43290 PRPF6 Homo sapiens O94906
Anti Tag CoIP
33961781
Intra
SART1 O43290 PRPF6 Homo sapiens O94906
Anti Bait CoIP
16723661
Intra
SART1 O43290 PRPF8 Homo sapiens Q6P2Q9
Crosslink
30021884
Intra
SART1 O43290 UBL5 Homo sapiens Q9BZL1
Y2H
15620657
Intra
SART1 O43290 UBL5 Homo sapiens Q9BZL1
Y2H
22365833
Intra
SART1 O43290 SNW1 Homo sapiens Q13573
Anti Tag CoIP
22365833
Intra
SART1 O43290 SNW1 Homo sapiens Q13573
Y2H
22365833
Intra
SART1 O43290 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra
SART1 O43290 HSF2BP Homo sapiens O75031
Validated Y2H
32296183
Intra
SART1 O43290 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra
SART1 O43290 PRPF3 Homo sapiens O43395
Anti Bait CoIP
16723661
Intra
SART1 O43290 PRPF3 Homo sapiens O43395
Anti Tag CoIP
33961781
Intra
SART1 O43290 SUMO1 Homo sapiens P63165
Affinity Chrom
17000644
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Squamous Cell Carcinoma

  • Epidermoid Carcinoma

  • Squamous Cell Cancer

  • Carcinoma, Squamous Cell

  • Squamous Cell Skin Cancer

  • Malignant Squamous Cell Tumor

  • Squamous Carcinoma

  • Squamous Cell Epithelioma

  • Carcinoma Squamous Cell

  • Neoplasms, Squamous Cell

  • Squamous Cell Carcinoma - Category

  • Malignant Squamous Cell Neoplasm

  • Squamous Cell Carcinoma Of Skin
Neutropenia, Severe Congenital, X-Linked

  • X-Linked Severe Congenital Neutropenia

  • XLN

  • SCNX

  • Severe Congenital Neutropenia X-Linked

  • Neutropenia, Congenital, Severe, X-Linked
Expressive Language Disorder

  • Developmental Expressive Language Disorder
Renal Cell Carcinoma, Nonpapillary

  • Renal Cell Carcinoma

  • RCC

  • Nonpapillary Renal Cell Carcinoma

  • Clear Cell Renal Cell Carcinoma

  • Hypernephroma

  • Adenocarcinoma Of Kidney

  • Renal Carcinoma, Chromophobe, Somatic

  • Clear Cell Carcinoma Of Kidney

  • Clear-Cell Metastatic Renal Cell Carcinoma

  • Clear Cell Renal Carcinoma

  • Renal Cell Carcinoma, Somatic

  • Conventional Renal Cell Carcinoma

  • Conventional Renal Cell Carcinoma

  • Renal Clear Cell Carcinoma

  • Ccrcc

  • Hereditary Clear Cell Renal Cell Carcinoma

  • Carcinoma, Renal Cell

  • Renal Cell Carcinoma, Clear Cell, Somatic

  • Renal Cell Carcinoma, Clear Cell

  • Clear Cell Kidney Carcinoma

  • Clear Cell Rcc

  • Cystic-Multilocular Variant

  • Clear Cell Renal Cell Adenocarcinoma

  • Hereditary Clear Cell Renal Cell Adenocarcinoma

  • Common Renal Cell Carcinoma

  • Crcc

  • Renal Cell Carcinoma Non-Papillary

  • Carcinoma Renal Cell

  • Renal Cell Cancer

  • Carcinoma, Renal Cell, Nonpapillary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12450 SART1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SART1 VGNC VGNC:76972
Rattus norvegicus SART1 RGD RGD:61930
Felis catus SART1 VGNC VGNC:64876
Mus musculus SART1 MGD MGI:1309453
Bos taurus SART1 VGNC VGNC:34292
Canis familiaris SART1 VGNC VGNC:45870
Others SART1 NCBI