PRPF3 - pre-mRNA processing factor 3 Gene

Also Known as PRP3; RP18; HPRP3; Prp3p; HPRP3P; SNRNP90

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9129

About PRPF3

Cytogenetic location: 1q21.2 Genomic coordinates (GRCh38): 1:150,321,468-150,353,233 (from NCBI)

This gene has 7 transcripts (splice variants), 203 orthologues and is associated with 3 phenotypes. Ubiquitous expression in bone marrow (RPKM 15.4), endometrium (RPKM 11.5) and 25 other tissues.

Summary

The removal of introns from nuclear pre-mRNAs occurs on complexes called spliceosomes, which are made up of 4 small nuclear ribonucleoprotein (snRNP) particles and an undefined number of transiently associated splicing factors. This gene product is one of several proteins that associate with U4 and U6 snRNPs. Mutations in this gene are associated with retinitis pigmentosa-18. [provided by RefSeq, Jul 2008]

PRPF3 Products (2)

mRNA	Protein	Name
NM_001350529.1	NP_001337458.1	U4/U6 small nuclear ribonucleoprotein Prp3 isoform 2
NM_004698.4	NP_004689.1	U4/U6 small nuclear ribonucleoprotein Prp3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	22365833	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15314151	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	28781166	GOA
involved in spliceosomal tri-snRNP complex assembly	IDA IDA: Inferred from direct assay	20595234	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Cajal body	IDA IDA: Inferred from direct assay	15257298	GOA
part of U2-type precatalytic spliceosome	IDA IDA: Inferred from direct assay	28781166	GOA
part of U4/U6 x U5 tri-snRNP complex	IDA IDA: Inferred from direct assay	26912367	GOA
located in nucleus	IDA IDA: Inferred from direct assay	20595234	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRPF3 Protein Structure

PWI

PRP3

DUF1115

0
200
400
600
683 a.a.

Protein Preferred Names	Protein Names
U4/U6 small nuclear ribonucleoprotein Prp3	PRP3 pre-mRNA processing factor 3 homolog

PRPF3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PRPF3	O43395	MID2	Homo sapiens	Q9UJV3-2	Y2H Bait-Prey Pool	25910212
Intra	PRPF3	O43395	MID2	Homo sapiens	Q9UJV3-2	Validated Y2H	25910212
Intra	PRPF3	O43395	MID2	Homo sapiens	Q9UJV3-2	Y2H Array	25910212
Intra	PRPF3	O43395	FAM9B	Homo sapiens	Q8IZU0	Y2H Prey Pooling	32296183
Intra	PRPF3	O43395	FAM9B	Homo sapiens	Q8IZU0	Validated Y2H	25910212
Intra	PRPF3	O43395	FAM9B	Homo sapiens	Q8IZU0	Y2H Bait-Prey Pool	25910212
Intra	PRPF3	O43395	FAM9B	Homo sapiens	Q8IZU0	Y2H Array	25910212
Intra	PRPF3	O43395	FAM9B	Homo sapiens	Q8IZU0	Validated Y2H	32296183
Intra	PRPF3	O43395	FAM9B	Homo sapiens	Q8IZU0	Y2H Array	32296183
Intra	PRPF3	O43395	FAM9B	Homo sapiens	Q8IZU0	Y2H Prey Pooling	25416956
Intra	PRPF3	O43395	MFAP1	Homo sapiens	P55081	Y2H	22365833
Intra	PRPF3	O43395	MFAP1	Homo sapiens	P55081	Anti Tag CoIP	22365833
Intra	PRPF3	O43395	OSBPL3	Homo sapiens	Q9H4L5	Y2H Prey Pooling	32296183
Intra	PRPF3	O43395	OSBPL3	Homo sapiens	Q9H4L5	Y2H Array	32296183
Intra	PRPF3	O43395	OSBPL3	Homo sapiens	Q9H4L5	Validated Y2H	32296183
Intra	PRPF3	O43395	SMNDC1	Homo sapiens	O75940	Y2H	22365833
Intra	PRPF3	O43395	U2AF2	Homo sapiens	P26368-2	Validated Y2H	32296183
Intra	PRPF3	O43395	U2AF2	Homo sapiens	P26368-2	Y2H Array	32296183
Intra	PRPF3	O43395	U2AF2	Homo sapiens	P26368-2	Y2H Prey Pooling	32296183
Intra	PRPF3	O43395	TRIM39	Homo sapiens	Q9HCM9-2	Y2H Prey Pooling	32296183
Intra	PRPF3	O43395	TRIM39	Homo sapiens	Q9HCM9-2	Validated Y2H	25910212
Intra	PRPF3	O43395	TRIM39	Homo sapiens	Q9HCM9-2	Y2H Bait-Prey Pool	25910212
Intra	PRPF3	O43395	TRIM39	Homo sapiens	Q9HCM9-2	Y2H Array	25910212
Intra	PRPF3	O43395	TRIM39	Homo sapiens	Q9HCM9-2	Validated Y2H	32296183
Intra	PRPF3	O43395	TRIM39	Homo sapiens	Q9HCM9-2	Y2H Array	32296183
Intra	PRPF3	O43395	PHC2	Homo sapiens	Q8IXK0-5	Validated Y2H	25910212
Intra	PRPF3	O43395	PHC2	Homo sapiens	Q8IXK0-5	Y2H Array	25910212
Intra	PRPF3	O43395	PHC2	Homo sapiens	Q8IXK0-5	Y2H Bait-Prey Pool	25910212
Intra	PRPF3	O43395	PIP4K2B	Homo sapiens	P78356-2	Y2H Array	32296183
Intra	PRPF3	O43395	PIP4K2B	Homo sapiens	P78356-2	Y2H Prey Pooling	32296183
Intra	PRPF3	O43395	PIP4K2B	Homo sapiens	P78356-2	Validated Y2H	32296183
Intra	PRPF3	O43395	CCDC125	Homo sapiens	Q86Z20	Validated Y2H	32296183
Intra	PRPF3	O43395	CCDC125	Homo sapiens	Q86Z20	Y2H Prey Pooling	32296183
Intra	PRPF3	O43395	CCDC125	Homo sapiens	Q86Z20	Y2H Array	32296183
Intra	PRPF3	O43395	FCHO1	Homo sapiens	A0A0C3SFZ9	Y2H Array	32296183
Intra	PRPF3	O43395	FCHO1	Homo sapiens	A0A0C3SFZ9	Y2H Prey Pooling	32296183
Intra	PRPF3	O43395	RNF151	Homo sapiens	Q2KHN1	Y2H Array	32296183
Intra	PRPF3	O43395	RNF151	Homo sapiens	Q2KHN1	Y2H Prey Pooling	32296183
Intra	PRPF3	O43395	RNF151	Homo sapiens	Q2KHN1	Validated Y2H	32296183
Intra	PRPF3	O43395	LZTS1	Homo sapiens	Q9Y250	Validated Y2H	32296183
Intra	PRPF3	O43395	LZTS1	Homo sapiens	Q9Y250	Y2H Prey Pooling	32296183
Intra	PRPF3	O43395	LZTS1	Homo sapiens	Q9Y250	Y2H Array	32296183
Intra	PRPF3	O43395	SSX2IP	Homo sapiens	Q9Y2D8	Validated Y2H	32296183
Intra	PRPF3	O43395	SSX2IP	Homo sapiens	Q9Y2D8	Y2H Array	32296183
Intra	PRPF3	O43395	SSX2IP	Homo sapiens	Q9Y2D8	Y2H Prey Pooling	32296183
Intra	PRPF3	O43395	SF3A2	Homo sapiens	Q15428	Affinity Chrom	17332742
Intra	PRPF3	O43395	PSMD3	Homo sapiens	O43242	Validated Y2H	25910212
Intra	PRPF3	O43395	PSMD3	Homo sapiens	O43242	Y2H Bait-Prey Pool	25910212
Intra	PRPF3	O43395	PSMD3	Homo sapiens	O43242	Y2H Array	25910212
Intra	PRPF3	O43395	TXLNA	Homo sapiens	P40222	Validated Y2H	32296183
Intra	PRPF3	O43395	TXLNA	Homo sapiens	P40222	Y2H Array	32296183
Intra	PRPF3	O43395	TXLNA	Homo sapiens	P40222	Y2H Prey Pooling	32296183
Intra	PRPF3	O43395	CARD10	Homo sapiens	Q9BWT7	Validated Y2H	32296183
Intra	PRPF3	O43395	CARD10	Homo sapiens	Q9BWT7	Y2H Array	32296183
Intra	PRPF3	O43395	CARD10	Homo sapiens	Q9BWT7	Y2H Prey Pooling	32296183
Intra	PRPF3	O43395	NKAPD1	Homo sapiens	Q6ZUT1	Y2H Array	32296183
Intra	PRPF3	O43395	NKAPD1	Homo sapiens	Q6ZUT1	Validated Y2H	32296183
Intra	PRPF3	O43395	NKAPD1	Homo sapiens	Q6ZUT1	Y2H Prey Pooling	32296183
Intra	PRPF3	O43395	RABEP1	Homo sapiens	Q15276	Validated Y2H	32296183
Intra	PRPF3	O43395	RABEP1	Homo sapiens	Q15276	Y2H Array	32296183
Intra	PRPF3	O43395	RABEP1	Homo sapiens	Q15276	Y2H Prey Pooling	32296183
Intra	PRPF3	O43395	GPRASP2	Homo sapiens	Q96D09	Y2H Array	25910212
Intra	PRPF3	O43395	GPRASP2	Homo sapiens	Q96D09	Y2H Bait-Prey Pool	25910212
Intra	PRPF3	O43395	GPRASP2	Homo sapiens	Q96D09	Validated Y2H	25910212
Intra	PRPF3	O43395	ZRANB1	Homo sapiens	Q9UGI0	Y2H Array	32296183
Intra	PRPF3	O43395	ZRANB1	Homo sapiens	Q9UGI0	Y2H Prey Pooling	32296183
Intra	PRPF3	O43395	ZRANB1	Homo sapiens	Q9UGI0	Validated Y2H	32296183
Intra	PRPF3	O43395	PRPF6	Homo sapiens	O94906	Pull Down	16723661
Intra	PRPF3	O43395	PRPF6	Homo sapiens	O94906	Anti Tag CoIP	28514442
Intra	PRPF3	O43395	PRPF6	Homo sapiens	O94906	Anti Tag CoIP	33961781
Intra	PRPF3	O43395	SART1	Homo sapiens	O43290	Y2H	16723661
Intra	PRPF3	O43395	SART1	Homo sapiens	O43290	Anti Tag CoIP	33961781
Intra	PRPF3	O43395	SART1	Homo sapiens	O43290	Anti Tag CoIP	28514442
Intra	PRPF3	O43395	GOLGA2	Homo sapiens	Q08379	Validated Y2H	32296183
Intra	PRPF3	O43395	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	PRPF3	O43395	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	PRPF3	O43395	HSF2BP	Homo sapiens	O75031	Validated Y2H	32296183
Intra	PRPF3	O43395	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
Intra	PRPF3	O43395	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
Intra	PRPF3	O43395	NKAP	Homo sapiens	Q8N5F7	Anti Tag CoIP	22365833
Intra	PRPF3	O43395	TSPYL	Homo sapiens	Q6FI91	Y2H Array	32296183
Intra	PRPF3	O43395	TSPYL	Homo sapiens	Q6FI91	Y2H Prey Pooling	32296183
Intra	PRPF3	O43395	TSPYL	Homo sapiens	Q6FI91	Validated Y2H	32296183
Intra	PRPF3	O43395	SHKBP1	Homo sapiens	Q8TBC3	Validated Y2H	32296183
Intra	PRPF3	O43395	SHKBP1	Homo sapiens	Q8TBC3	Y2H Array	32296183
Intra	PRPF3	O43395	SHKBP1	Homo sapiens	Q8TBC3	Y2H Prey Pooling	32296183
Intra	PRPF3	O43395	TRIM39	Homo sapiens	Q9HCM9	Y2H Prey Pooling	25416956
Intra	PRPF3	O43395	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	32296183
Intra	PRPF3	O43395	CEP70	Homo sapiens	Q8NHQ1	Validated Y2H	32296183
Intra	PRPF3	O43395	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	32296183
Intra	PRPF3	O43395	DVL3	Homo sapiens	Q92997	Pull Down	16189514
Intra	PRPF3	O43395	U2AF2	Homo sapiens	P26368	Y2H	22365833
Intra	PRPF3	O43395	SART3	Homo sapiens	Q15020	Anti Tag CoIP	33961781
Intra	PRPF3	O43395	SART3	Homo sapiens	Q15020	Anti Tag CoIP	28514442
Intra	PRPF3	O43395	PRPF4	Homo sapiens	O43172	Anti Tag CoIP	33961781
Intra	PRPF3	O43395	SF3B2	Homo sapiens	Q13435	Anti Tag CoIP	22365833
Intra	PRPF3	O43395	SF3B2	Homo sapiens	Q13435	Y2H	22365833
Intra	PRPF3	O43395	SLU7	Homo sapiens	O95391	Anti Tag CoIP	22365833
Intra	PRPF3	O43395	SLU7	Homo sapiens	O95391	Y2H	22365833
Intra	PRPF3	O43395	NACC1	Homo sapiens	Q96RE7	Y2H Prey Pooling	32296183
Intra	PRPF3	O43395	NACC1	Homo sapiens	Q96RE7	Validated Y2H	32296183
Intra	PRPF3	O43395	NACC1	Homo sapiens	Q96RE7	Y2H Array	32296183
Intra	PRPF3	O43395	ZFPM2	Homo sapiens	Q8WW38	Y2H Prey Pooling	32296183
Intra	PRPF3	O43395	ZFPM2	Homo sapiens	Q8WW38	Validated Y2H	32296183
Intra	PRPF3	O43395	ZFPM2	Homo sapiens	Q8WW38	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

PRPF3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810032	PRPF3 Antibody (YA9376)	WB, ICC/IF, IF-Tissue, IP, ELISA	human

Related Diseases

Diseases	Alias
Retinitis Pigmentosa 18	RP18 Retinitis Pigmentosa-18 Retinitis Pigmentosa, Type 18
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Fundus Dystrophy	Retinal Dystrophy Retinal Dystrophies Dystrophy, Retinal
Cone-Rod Dystrophy 2	Cone-Rod Dystrophy CORD2 Cone-Rod Retinal Dystrophy Rcrd2 Cone-Rod Retinal Dystrophy 2 Crd2 Cord Crd Retinal Cone-Rod Dystrophy Cone-Rod Retinal Dystrophy-2 Retinal Cone-Rod Dystrophy 2 Tapetoretinal Degeneration Cone-Rod Degeneration Cone Rod Dystrophy Dystrophy, Cone-Rod Dystrophy, Cone-Rod, Type 2 Retinitis Pigmentosa Retinitis Pigmentosa 2 Progressive Cone-Rod Dystrophy
Retinitis
Midline Cystocele
Microphthalmia, Syndromic 5	MCOPS5 Syndromic Microphthalmia Type 5 Retinal Dystrophy, Early-Onset, With Or Without Pituitary Dysfunction Syndromic Microphthalmia 5 Syndromic Microphthalmia/Anophthalmia Due To Otx2 Mutation Microphthalmia Syndromic 5 Otx2-Related Eye Disorders Microphthalmia, Syndromic, 5 RDEOP Microphthalmia, Syndromic, Type 5
Retinitis Pigmentosa 9	RP9 Retinitis Pigmentosa-9 Retinitis Pigmentosa, Type 9
Pseudoretinitis Pigmentosa	Secondary Pigmentary Retinal Degeneration Secondary Pigmentary Degeneration Of Retina
Retinitis Pigmentosa 13	RP13 Retinitis Pigmentosa-13 Retinitis Pigmentosa, Type 13
Retinitis Pigmentosa 33	RP33 Retinitis Pigmentosa, Type 33
Retinitis Pigmentosa 63	RP63
Retinitis Pigmentosa 31	RP31 Retinitis Pigmentosa-31 Retinitis Pigmentosa, Type 31
Microcephalic Osteodysplastic Primordial Dwarfism, Type I	Taybi-Linder Syndrome Brachymelic Primordial Dwarfism Cephaloskeletal Dysplasia Low-Birth-Weight Dwarfism With Skeletal Dysplasia Microcephalic Osteodysplastic Primordial Dwarfism Type I Osteodysplastic Primordial Dwarfism Type I Primordial Microcephalic Dwarfism, Crachami Type Osteodysplastic Primordial Dwarfism, Type 1 MOPD1 Mopd I Mopd Osteodysplastic Primordial Dwarfism, Type I Tals Microcephalic Osteodysplastic Primordial Dwarfism Type 1 Mopd 1 Microcephalic Osteodysplastic Primordial Dwarfism Types 1 And 3 Microcephalic Osteodysplastic Primordial Dwarfism Types I And Iii Mopd Types I And Iii Microcephalic Osteodysplastic Primordial Dwarfism, Taybi-Linder Type Primordial Microcephalic Dwarfism Crachami Type Dwarfism, Primordial, Osteodysplastic, Microcephalic, Type 1
Retinitis Pigmentosa 1	RP1 Retinitis Pigmentosa-1 Retinitis Pigmentosa, Type 1
Mandibulofacial Dysostosis, Guion-Almeida Type	Mandibulofacial Dysostosis With Microcephaly Mandibulofacial Dysostosis-Microcephaly Syndrome MFDGA MFDM Mfdm Syndrome Growth And Mental Retardation, Mandibulofacial Dysostosis, Microcephaly, And Cleft Palate Growth Delay - Intellectual Disability - Mandibulofacial Dysostosis - Microcephaly - Cleft Palate Growth Delay-Intellectual Disability-Mandibulofacial Dysostosis-Microcephaly-Cleft Palate Syndrome Dysostosis, Mandibulofacial, Guion-Almeida Type
Retinal Degeneration	Degeneration Of Retina
Trichohepatoenteric Syndrome 1	Trichohepatoenteric Syndrome Syndromic Diarrhea Tricho-Hepato-Enteric Syndrome Sd/The Syndromic Diarrhea/Tricho-Hepato-Enteric Syndrome THES1 Phenotypic Diarrhea Thes Phenotypic Diarrhea Of Infancy Diarrhea, Syndromic Diarrhea, Fatal Infantile, With Trichorrhexis Nodosa Intractable Diarrhea With Phenotypic Anomalies Syndromatic Diarrhea Fatal Infantile Diarrhea With Trichorrhexis Nodosa
Eye Degenerative Disease
Retinitis Pigmentosa 11	RP11 Retinitis Pigmentosa-11 Retinitis Pigmentosa, Type 11
Stargardt Disease	Stargardt Disease 1 Stargardt Macular Dystrophy Stargardt Disease-1 Juvenile Onset Macular Degeneration Stargardt Macular Degeneration Juvenile Macular Degeneration Macular Dystrophy With Flecks, Type 1 Stgd Fundus Flavimaculatus Stargardt 1 Stargardts Disease
Cone Dystrophy	Retinal Cone Dystrophy Dystrophy, Cone Cone Dystrophy 3
Congenital Stationary Night Blindness	Night Blindness, Congenital Stationary Congenital Essential Nyctalopia Oguchi Disease Blindness, Night, Stationary, Congenital
Usher Syndrome	Deafness-Retinitis Pigmentosa Syndrome Dystrophia Retinae Pigmentosa-Dysostosis Syndrome Graefe-Usher Syndrome Hallgren Syndrome Usher'S Syndrome Retinitis Pigmentosa-Deafness Syndrome Retinitis Pigmentosa-Hearing Loss Syndrome Ush Usher Syndromes
Leber Plus Disease	Leber Congenital Amaurosis Lca Leber'S Amaurosis Leber'S Disease Amaurosis Congenita Of Leber Amaurosis Congenita Of Leber, Type 1 Lhon Plus Disease Congenital Absence Of The Rods And Cones Congenital Retinal Blindness Crb Congenital Amaurosis Of Retinal Origin Leber'S Congenital Amaurosis Leber Congenital Amaurosis 1 Leber'S Congenital Tapetoretinal Degeneration Leber'S Congenital Tapetoretinal Dysplasia Lca1 Leber Congenital Amaurosis Type 1 Retinal Blindness, Congenital Amaurosis, Leber Congenital Dysgenesis Neuroepithelialis Retinae Hereditary Epithelial Dysplasia Of Retina Hereditary Retinal Aplasia Heredoretinopathia Congenitalis Leber Abiotrophy Leber Congenital Tapetoretinal Degeneration Lebers Congenital Amaurosis Optic Atrophy, Hereditary, Leber
Eye Disease	Eye Diseases Abnormality Of The Eye Toxoplasma Oculopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11207	PRPF3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PRPF3	VGNC	VGNC:64370
Rattus norvegicus	PRPF3	RGD	RGD:1310555
Bos taurus	PRPF3	VGNC	VGNC:33373
Macaca mulatta	PRPF3	VGNC	VGNC:76277
Canis familiaris	PRPF3	VGNC	VGNC:45020
Mus musculus	PRPF3	MGD	MGI:1918017
Others	PRPF3	NCBI