2. Gene
  3. SART3 - spliceosome associated factor 3, U4/U6 recycling protein Gene

SART3 - spliceosome associated factor 3, U4/U6 recycling protein Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as P100; p110; DSAP1; TIP110; p110(nrb); RP11-13G14

Gene ID: 9733 | Gene type: protein coding

About SART3

Cytogenetic location: 12q23.3 Genomic coordinates (GRCh38): 12:108,522,214-108,561,173 (from NCBI)

This gene has 17 transcripts (splice variants) and 210 orthologues. Ubiquitous expression in testis (RPKM 12.7), lymph node (RPKM 12.3) and 25 other tissues.

Summary

The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in Cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6 snRNPs during the recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the regulation of mRNA splicing. [provided by RefSeq, Jul 2008]

SART3 Products(2)

mRNA Protein Name
NM_001410983.1 NP_001397912.1 squamous cell carcinoma antigen recognized by T-cells 3 isoform 2
NM_014706.4 NP_055521.1 squamous cell carcinoma antigen recognized by T-cells 3 isoform 1

SART3 Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (706 - 774)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (803 - 871)

Lsm_interact

Lsm_interact: Lsm interaction motif (942 - 962)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 963 a.a.
Protein Preferred Names Protein Names

squamous cell carcinoma antigen recognized by T-cells 3

HIV-1 Tat-interacting protein of 110kDa

Related Diseases

Diseases Alias
Porokeratosis

Disseminated Superficial Actinic Porokeratosis

Dsap

Porokeratosis Of Mibelli

Porokeratosis, Disseminated Superficial Actinic

Porokeratosis, Disseminated Superficial Actinic, 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12451 SART3 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SART3 VGNC VGNC:77029
Canis familiaris SART3 VGNC VGNC:57174
Rattus norvegicus SART3 RGD RGD:1311646
Mus musculus SART3 MGD MGI:1858230
Bos taurus SART3 VGNC VGNC:57216
Felis catus SART3 VGNC VGNC:64877