SART3 - spliceosome associated factor 3, U4/U6 recycling protein Gene

Also Known as P100; p110; DSAP1; TIP110; p110(nrb); RP11-13G14

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9733

About SART3

Cytogenetic location: 12q23.3 Genomic coordinates (GRCh38): 12:108,522,214-108,561,173 (from NCBI)

This gene has 17 transcripts (splice variants) and 210 orthologues. Ubiquitous expression in testis (RPKM 12.7), lymph node (RPKM 12.3) and 25 other tissues.

Summary

The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in Cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6 snRNPs during the recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the regulation of mRNA splicing. [provided by RefSeq, Jul 2008]

SART3 Products (2)

mRNA	Protein	Name
NM_001410983.1	NP_001397912.1	squamous cell carcinoma antigen recognized by T-cells 3 isoform 2
NM_014706.4	NP_055521.1	squamous cell carcinoma antigen recognized by T-cells 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
NOT enables U4 snRNA binding	IDA IDA: Inferred from direct assay	15314151	GOA
enables U4 snRNA binding	IDA IDA: Inferred from direct assay	12032085	GOA
NOT enables U6 snRNA binding	IDA IDA: Inferred from direct assay	15314151	GOA
enables U6 snRNA binding	IDA IDA: Inferred from direct assay	12032085	GOA
enables U6atac snRNA binding	IDA IDA: Inferred from direct assay	14749385	GOA
enables histone binding	IDA IDA: Inferred from direct assay	24526689	GOA
enables protein binding	IDA IDA: Inferred from direct assay	32839293	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11477570	GOA
enables ubiquitin-specific protease binding	IPI IPI: Inferred from physical interaction	20595234	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	15314151	GOA
involved in nucleosome assembly	IDA IDA: Inferred from direct assay	24526689	GOA
acts upstream of or within regulation of gene expression	IDA IDA: Inferred from direct assay	21447833	GOA
NOT involved in spliceosomal snRNP assembly	IDA IDA: Inferred from direct assay	15314151	GOA
involved in spliceosomal snRNP assembly	IDA IDA: Inferred from direct assay	14749385	GOA
involved in spliceosomal tri-snRNP complex assembly	IDA IDA: Inferred from direct assay	12032085	GOA
involved in transcription elongation-coupled chromatin remodeling	IDA IDA: Inferred from direct assay	24526689	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Cajal body	IDA IDA: Inferred from direct assay	12578909	GOA
part of U4/U6 snRNP	IDA IDA: Inferred from direct assay	12032085	GOA
NOT part of U4/U6 x U5 tri-snRNP complex	IDA IDA: Inferred from direct assay	12032085	GOA
NOT part of U4atac/U6atac snRNP	IDA IDA: Inferred from direct assay	14749385	GOA
part of U6atac snRNP	IDA IDA: Inferred from direct assay	14749385	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	12578909	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	32839293	GOA
located in nucleus	IDA IDA: Inferred from direct assay	24526689	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SART3 Protein Structure

RRM_1

Lsm_interact

0
200
400
600
800
963 a.a.

Protein Preferred Names	Protein Names
squamous cell carcinoma antigen recognized by T-cells 3	HIV-1 Tat-interacting protein of 110kDa

SART3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SART3	Q15020	RNPS1	Homo sapiens	Q15287	Pull Down	11477570
Intra	SART3	Q15020	RNPS1	Homo sapiens	Q15287	Y2H	11477570
Intra	SART3	Q15020	RNPS1	Homo sapiens	Q15287	Anti Bait CoIP	11477570
Intra	SART3	Q15020	RNPS1	Homo sapiens	Q15287	Confocal	11477570
Intra	SART3	Q15020	ZNF620	Homo sapiens	Q6ZNG0	Validated Y2H	32296183
Intra	SART3	Q15020	ZNF620	Homo sapiens	Q6ZNG0	Y2H Prey Pooling	32296183
Intra	SART3	Q15020	ZNF620	Homo sapiens	Q6ZNG0	Y2H Array	32296183
Intra	SART3	Q15020	ZNF71	Homo sapiens	Q9NQZ8	Y2H Prey Pooling	32296183
Intra	SART3	Q15020	ZNF71	Homo sapiens	Q9NQZ8	Y2H Array	32296183
Intra	SART3	Q15020	ZNF71	Homo sapiens	Q9NQZ8	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Porokeratosis	Disseminated Superficial Actinic Porokeratosis Dsap Porokeratosis Of Mibelli Porokeratosis, Disseminated Superficial Actinic Porokeratosis, Disseminated Superficial Actinic, 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12451	SART3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SART3	VGNC	VGNC:77029
Canis familiaris	SART3	VGNC	VGNC:57174
Rattus norvegicus	SART3	RGD	RGD:1311646
Mus musculus	SART3	MGD	MGI:1858230
Bos taurus	SART3	VGNC	VGNC:57216
Felis catus	SART3	VGNC	VGNC:64877
Others	SART3	NCBI