Prdm1 - PR domain containing 1, with ZNF domain Gene

Also Known as Blimp1; Blimp-1; PRDI-BF1; ZNFPR1A1; b2b1765Clo

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12142

Summary

Enables histone deacetylase binding activity; promoter-specific chromatin binding activity; and sequence-specific DNA binding activity. Involved in regulation of NK T cell differentiation; regulation of extrathymic T cell differentiation; and regulation of natural killer cell differentiation. Acts upstream of or within several processes, including animal organ development; artery development; and regulation of B cell activation. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; embryo mesenchyme; reproductive system; retina; and skin. Used to study systemic lupus erythematosus. Orthologous to human PRDM1 (PR/SET domain 1). [provided by Alliance of Genome Resources, Apr 2022]

Prdm1 Products (9)

mRNA Protein Name
NM_001405929.1 NP_001392858.1 PR domain zinc finger protein 1 isoform 1
NM_001405930.1 NP_001392859.1 PR domain zinc finger protein 1 isoform 2
NM_001405931.1 NP_001392860.1 PR domain zinc finger protein 1 isoform 3
NM_001405932.1 NP_001392861.1 PR domain zinc finger protein 1 isoform 5
NM_001405933.1 NP_001392862.1 PR domain zinc finger protein 1 isoform 5
NM_001405934.1 NP_001392863.1 PR domain zinc finger protein 1 isoform 6
NM_001405935.1 NP_001392864.1 PR domain zinc finger protein 1 isoform 7
NM_001405936.1 NP_001392865.1 PR domain zinc finger protein 1 isoform 8
NM_007548.5 NP_031574.2 PR domain zinc finger protein 1 isoform 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables histone methyltransferase binding IPI
IPI: Inferred from physical interaction
16699504 MGI
enables promoter-specific chromatin binding IDA
IDA: Inferred from direct assay
27102484 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
21722636 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
32741026 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within aorta development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within artery morphogenesis IGI
IGI: Inferred from genetic interaction
24821700 MGI
acts upstream of or within artery morphogenesis IMP
IMP: Inferred from mutant phenotype
24821700 MGI
acts upstream of or within cardiac septum development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within cell fate commitment IMP
IMP: Inferred from mutant phenotype
15750184 MGI
acts upstream of or within coronary vasculature development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within embryonic placenta development IMP
IMP: Inferred from mutant phenotype
15750184 MGI
acts upstream of or within eye photoreceptor cell development IMP
IMP: Inferred from mutant phenotype
20463215 MGI
involved in gene expression IDA
IDA: Inferred from direct assay
16699504 MGI
acts upstream of or within germ cell development IGI
IGI: Inferred from genetic interaction
19578360 MGI
acts upstream of or within heart valve development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
15750184 MGI
acts upstream of or within intestinal epithelial cell development IMP
IMP: Inferred from mutant phenotype
21670299 MGI
acts upstream of or within kidney development IMP
IMP: Inferred from mutant phenotype
27002738 MGI
acts upstream of or within maternal placenta development IMP
IMP: Inferred from mutant phenotype
15750184 MGI
acts upstream of or within morphogenesis of a branching structure IMP
IMP: Inferred from mutant phenotype
24821700 MGI
acts upstream of or within negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
21670299 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
20463215 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
32741026 MGI
involved in peptidyl-arginine methylation IDA
IDA: Inferred from direct assay
16699504 MGI
acts upstream of or within positive regulation of gene expression IDA
IDA: Inferred from direct assay
18622394 MGI
acts upstream of or within post-embryonic development IMP
IMP: Inferred from mutant phenotype
21670299 MGI
involved in regulation of NK T cell differentiation IMP
IMP: Inferred from mutant phenotype
27102484 MGI
acts upstream of or within regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
24821700 MGI
involved in regulation of extrathymic T cell differentiation IMP
IMP: Inferred from mutant phenotype
27102484 MGI
involved in regulation of natural killer cell differentiation IMP
IMP: Inferred from mutant phenotype
27102484 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
28199486 MGI
acts upstream of or within retinal bipolar neuron differentiation IMP
IMP: Inferred from mutant phenotype
28199486 MGI
acts upstream of or within sebum secreting cell proliferation IDA
IDA: Inferred from direct assay
16901790 MGI
acts upstream of or within trophoblast giant cell differentiation IMP
IMP: Inferred from mutant phenotype
22987638 MGI
acts upstream of or within ventricular septum development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
Cellular Component GO Annotation Evidence References Source
is active in cytoplasm IDA
IDA: Inferred from direct assay
16699504 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
32741026 MGI
is active in nucleus IDA
IDA: Inferred from direct assay
16699504 MGI
located in nucleus IDA
IDA: Inferred from direct assay
16901790 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

PR domain zinc finger protein 1

  • B lymphocyte induced maturation protein

  • B lymphocyte-induced maturation protein 1

  • PR domain-containing protein 1

  • beta-interferon gene positive regulatory domain I-binding factor

Prdm1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Prdm1 Q60636 SUMO1 Homo sapiens P63165
Anti Tag CoIP
21722636
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11059 PRDM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19474 Prdm1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25967 Prdm1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prdm1 NCBI NCBI:639