PRDM1 - PR/SET domain 1 Gene

Also Known as BLIMP1; PRDI-BF1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 639

About PRDM1

Cytogenetic location: 6q21 Genomic coordinates (GRCh38): 6:105,992,690-106,109,938 (from NCBI)

This gene has 10 transcripts (splice variants), 211 orthologues, 36 paralogues and is associated with 99 phenotypes. Broad expression in esophagus (RPKM 16.3), endometrium (RPKM 7.2) and 17 other tissues.

Summary

This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported. [provided by RefSeq, Jul 2008]

PRDM1 Products (2)

mRNA	Protein	Name
NM_001198.4	NP_001189.2	PR domain zinc finger protein 1 isoform 1
NM_182907.3	NP_878911.1	PR domain zinc finger protein 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	1851123	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	1851123	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22555612	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	1851123	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	21421998	GOA
located in nucleus	IDA IDA: Inferred from direct assay	28842558	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRDM1 Protein Structure

SET

zf-H2C2_2

0
200
400
600
825 a.a.

Protein Preferred Names	Protein Names
PR domain zinc finger protein 1	B-lymphocyte-induced maturation protein 1

PRDM1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81356	PRDM1/Blimp1 Antibody (YA1101)	IHC-P	Human
HY-P81356A	PRDM1/Blimp1 Antibody (YA1101)(PBS only)	IHC-P	Human
HY-P83866	PRDM1/Blimp1 Antibody (YA3563)	WB, ICC/IF, FC, ELISA	Human, Mouse, Rat, Monkey
HY-P83866A	PRDM1/Blimp1 Antibody (YA3563)(PBS only)	WB, ICC/IF, FC, ELISA	Human, Mouse, Rat, Monkey
HY-P85055	PRDM1/Blimp1 Antibody (YA4747)	WB, ELISA	Human, Mouse

Related Diseases

Diseases	Alias
Plasmablastic Lymphoma	Pbl Immunoblastic Large-Cell Lymphoma
B-Cell Lymphoma	Lymphoma, B-Cell B-Cell Lymphomas B-Cell Lymphocytic Neoplasm Lymphoma B-Cell B-Cell Lymphoma Nos
Lymphoma	Lymphoid Cancer Lymphomas Lymphoid Cancers Lymphoid Neoplasm Lymphoma Nos Nhl - [Non-Hodgkin Lymphoma] Non-Hodgkin Lymphoma Non-Hodgkin Lymphoma, Nos Non-Hodgkin Malignant Lymphoma Nos
Selective Igg Deficiency Disease	Igg Deficiency Immunoglobin G Subclass Deficiency Selective Deficiency Of Igg Selective Igg Immunodeficiency Selective Immunoglobulin G Deficiency Selective Immunoglobulin G Subclass Deficiency
Diffuse Large B-Cell Lymphoma	Dlbcl Diffuse Large B-Cell Lymphoma, Not Otherwise Specified Large B-Cell Diffuse Lymphoma Lymphoma, Large B-Cell, Diffuse Dlbcl - [Diffuse Large B-Cell Lymphoma] Diffuse Large Beta Cell Lymphoma
B-Cell Non-Hodgkin Lymphoma	B-Cell Nhl B-Cell Non-Hodgkins Lymphoma
Monoclonal Paraproteinemia	Monoclonal Paraproteinaemia
Plasmacytoma	Solitary Plasmacytoma Solitary Myeloma Myeloma - Solitary Myeloma, Solitary Plasmacytoma - Category Solitary Osseous Plasmacytoma Solitary Plasmacytoma Without Mention Of Remission Localised Malignant Plasma Cell Tumour Nos Plasmacytoma Nos
Oral Hairy Leukoplakia	Hairy Leukoplakia Leukoplakia, Hairy Hairy Leucoplakia
Burkitt Lymphoma	Burkitt'S Lymphoma BL Burkitt Lymphoma, Somatic Burkitt Lymphoma/Leukaemia Burkitt'S Tumor Burkitt'S Tumor Or Lymphoma Malignant Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma Burkitt Tumor Burkitts Lymphoma Lymphoma, Small Noncleaved-Cell Burkitt Tumour Diffuse Small Noncleaved Malignant Burkitt Lymphoma Malignant Burkitt Lymphoma “Burkitt-Like” Lymphoma Undifferentiated Burkitt Lymphoma Small Noncleaved Cell Burkitt Lymphoma
Common Variable Immunodeficiency	Cvid Common Variable Agammaglobulinemia Common Variable Immune Deficiency Acquired Hypogammaglobulinemia Hypogamma-Globulinemia, Acquired Idiopathic Immunoglobulin Deficiency Primary Antibody Deficiency Primary Hypogammaglobulinemia Acquired Agammaglobulinemia Sporadic Hypogammaglobulinemia Common Variable Hypogamma-Globulinemia Immunoglobulin Deficiency, Late-Onset Common Variable Hypogammaglobulinemia Immunodeficiency, Common Variable
Immunodeficiency 60	Bach2-Related Immunodeficiency And Autoimmunity Brida Imd60
Adult Lymphoma
Myeloma, Multiple	Multiple Myeloma Plasma Cell Myeloma Kahler Disease Myelomatosis Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Kahler'S Disease Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Mature B-Cell Neoplasm	Mature B-Cell Lymphocytic Neoplasm Neoplasm Of Mature B-Cells Mature B-Cell Non-Hodgkin Neoplasm With Leukaemic Behaviour
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11059	PRDM1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19474	Prdm1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25967	Prdm1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PRDM1	VGNC	VGNC:44944
Felis catus	PRDM1	VGNC	VGNC:69033
Macaca mulatta	PRDM1	VGNC	VGNC:76391
Rattus norvegicus	PRDM1	RGD	RGD:1311765
Bos taurus	PRDM1	VGNC	VGNC:33288
Mus musculus	PRDM1	MGD	MGI:99655
Others	PRDM1	NCBI