PID1 - phosphotyrosine interaction domain containing 1 Gene

Also Known as PCLI1; NYGGF4; P-CLI1; HMFN2073

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55022

About PID1

Cytogenetic location: 2q36.3 Genomic coordinates (GRCh38): 2:229,023,973-229,271,287 (from NCBI)

This gene has 6 transcripts (splice variants) and 200 orthologues. Ubiquitous expression in brain (RPKM 7.9), liver (RPKM 5.4) and 24 other tissues.

Summary

Involved in several processes, including mitochondrion morphogenesis; negative regulation of phosphate metabolic process; and positive regulation of macromolecule metabolic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PID1 Products (5)

mRNA Protein Name
NM_001100818.2 NP_001094288.1 PTB-containing, cubilin and LRP1-interacting protein isoform 2
NM_001330156.1 NP_001317085.1 PTB-containing, cubilin and LRP1-interacting protein isoform 3
NM_001330157.2 NP_001317086.1 PTB-containing, cubilin and LRP1-interacting protein isoform 4
NM_001330158.2 NP_001317087.1 PTB-containing, cubilin and LRP1-interacting protein isoform 5
NM_017933.5 NP_060403.3 PTB-containing, cubilin and LRP1-interacting protein isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
NOT involved in fat cell differentiation IDA
IDA: Inferred from direct assay
16815647 GOA
involved in mitochondrion organization IMP
IMP: Inferred from mutant phenotype
20165904 GOA
involved in negative regulation of ATP biosynthetic process IMP
IMP: Inferred from mutant phenotype
20165904 GOA
involved in negative regulation of D-glucose import IDA
IDA: Inferred from direct assay
19079291 GOA
involved in negative regulation of insulin receptor signaling pathway IDA
IDA: Inferred from direct assay
19079291 GOA
involved in negative regulation of protein localization to plasma membrane IDA
IDA: Inferred from direct assay
19079291 GOA
involved in negative regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
19079291 GOA
involved in positive regulation of fat cell proliferation IDA
IDA: Inferred from direct assay
16815647 GOA
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
20165904 GOA
involved in positive regulation of reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
20165904 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
20165904 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16815647 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PID1 Protein Structure

PID_2

PID_2: Phosphotyrosine interaction domain (PTB/PID) (92 - 233)

  • 0
  • 100
  • 200
  • 250 a.a.
Protein Preferred Names Protein Names

PTB-containing, cubilin and LRP1-interacting protein

  • phosphotyrosine interaction domain-containing protein 1

PID1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PID1 Q7Z2X4 ADAMTSL4 Homo sapiens Q6UY14-3
Validated Y2H
25416956
Intra
PID1 Q7Z2X4 GOPC Homo sapiens Q9HD26
Validated Y2H
25416956
Intra
PID1 Q7Z2X4 GOPC Homo sapiens Q9HD26
Y2H Array
25416956
Intra
PID1 Q7Z2X4 q96t11_human Homo sapiens Q96T11
Anti Tag CoIP
33961781
Intra
PID1 Q7Z2X4 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
25416956
Intra
PID1 Q7Z2X4 MDFI Homo sapiens Q99750
Y2H Prey Pooling
25416956
Intra
PID1 Q7Z2X4 NME1 Homo sapiens P15531
Y2H Prey Pooling
25416956
Intra
PID1 Q7Z2X4 NME1 Homo sapiens P15531
Y2H Array
25416956
Intra
PID1 Q7Z2X4 THAP1 Homo sapiens Q9NVV9
Y2H Prey Pooling
25416956
Intra
PID1 Q7Z2X4 THAP1 Homo sapiens Q9NVV9
Y2H Array
25416956
Intra
PID1 Q7Z2X4 CBY2 Homo sapiens Q8NA61
Validated Y2H
25416956
Intra
PID1 Q7Z2X4 CBY2 Homo sapiens Q8NA61
Y2H Array
25416956
Intra
PID1 Q7Z2X4 BANP Homo sapiens Q8N9N5
Y2H Prey Pooling
25416956
Intra
PID1 Q7Z2X4 CRX Homo sapiens O43186
Y2H Prey Pooling
25416956
Intra
PID1 Q7Z2X4 NOTCH2NLA Homo sapiens Q7Z3S9
Validated Y2H
25416956
Intra
PID1 Q7Z2X4 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10480 PID1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21409 Pid1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27928 Pid1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PID1 VGNC VGNC:32862
Canis familiaris PID1 VGNC VGNC:44526
Rattus norvegicus PID1 RGD RGD:1560766
Felis catus PID1 VGNC VGNC:80302
Macaca mulatta PID1 VGNC VGNC:75869
Mus musculus PID1 MGD MGI:2138391
Others PID1 NCBI