ACOT7 - acyl-CoA thioesterase 7 Gene

Also Known as ACT; ACH1; BACH; LACH; LACH1; hBACH; CTE-II

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11332

About ACOT7

Cytogenetic location: 1p36.31 Genomic coordinates (GRCh38): 1:6,264,272-6,393,767 (from NCBI)

This gene has 10 transcripts (splice variants), 194 orthologues and 2 paralogues. Broad expression in brain (RPKM 26.5), kidney (RPKM 21.3) and 22 other tissues.

Summary

This gene encodes a member of the acyl coenzyme family. The encoded protein hydrolyzes the CoA thioester of palmitoyl-CoA and Other long-chain fatty acids. Decreased expression of this gene may be associated with mesial temporal lobe epilepsy. Alternatively spliced transcript variants encoding distinct isoforms with different subcellular locations have been characterized. [provided by RefSeq, Jul 2008]

ACOT7 Products (4)

mRNA Protein Name
NM_007274.4 NP_009205.3 cytosolic acyl coenzyme A thioester hydrolase isoform hBACHa
NM_181864.3 NP_863654.1 cytosolic acyl coenzyme A thioester hydrolase isoform hBACHb
NM_181865.3 NP_863655.1 cytosolic acyl coenzyme A thioester hydrolase isoform hBACHc
NM_181866.3 NP_863656.1 cytosolic acyl coenzyme A thioester hydrolase isoform hBACHd

ACOT7 Protein Structure

4HBT

4HBT: Thioesterase superfamily (69 - 149)

4HBT

4HBT: Thioesterase superfamily (242 - 311)

  • 0
  • 100
  • 200
  • 300
  • 380 a.a.
Protein Preferred Names Protein Names

cytosolic acyl coenzyme A thioester hydrolase

  • CTE-IIa

ACOT7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ACOT7 O00154 UBQLN1 Homo sapiens Q9UMX0-2
Y2H Prey Pooling
25416956
Intra
ACOT7 O00154 HEL-S-101 Homo sapiens V9HW27
Validated Y2H
25416956
Intra
ACOT7 O00154 HEL-S-101 Homo sapiens V9HW27
Y2H Array
25416956
Intra
ACOT7 O00154 MAGEA6 Homo sapiens P43360
Y2H Prey Pooling
25416956
Intra
ACOT7 O00154 MAGEA6 Homo sapiens P43360
Validated Y2H
25416956
Intra
ACOT7 O00154 CAMK2B Homo sapiens Q13554
Validated Y2H
25416956
Intra
ACOT7 O00154 CAMK2B Homo sapiens Q13554
Y2H Array
25416956
Intra
ACOT7 O00154 CHD8 Homo sapiens Q9HCK8
Crosslink
26949739
Intra
ACOT7 O00154 FMR1 Homo sapiens Q06787
Crosslink
26949739
Intra
ACOT7 O00154 CUL3 Homo sapiens Q13618
Crosslink
26949739
Intra
ACOT7 O00154 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
25416956
Intra
ACOT7 O00154 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
25416956
Intra
ACOT7 O00154 UBQLN1 Homo sapiens Q9UMX0
Y2H Prey Pooling
25416956
Intra
ACOT7 O00154 THAP1 Homo sapiens Q9NVV9
Y2H Prey Pooling
25416956
Intra
ACOT7 O00154 THAP1 Homo sapiens Q9NVV9
Y2H Array
25416956
Intra
ACOT7 O00154 ANK2 Homo sapiens Q01484
Crosslink
26949739
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Temporal Lobe Epilepsy

  • Epilepsy, Temporal Lobe

  • Epilepsy Temporal Lobe
Hyperinsulinemic Hypoglycemia, Familial, 7

  • HHF7

  • Exercise-Induced Hyperinsulinemic Hypoglycemia

  • Exercise-Induced Hyperinsulinism

  • Familial Hyperinsulinemic Hypoglycemia 7

  • Eihi

  • Hyperinsulinism Due To Monocarboxylate Transporter 1 Deficiency

  • Hyperinsulinism Due To Slc16a1 Deficiency

  • Hyperinsulinemic Hypoglycemia, Exercise-Induced

  • Exercise Induced Hyperinsulinemic Hypoglycemia

  • Hyperinsulinemic Hypoglycemia Exercise-Induced

  • Hyperinsulinemic Hypoglycemia Familial 7
Pontocerebellar Hypoplasia, Type 16

  • PCH16

  • Pontocerebellar Hypoplasia Type 16

  • Pontocerebellar Hypoplasia 16

  • Doid:0112333
Epilepsy

  • Epilepsy Syndrome

  • Epileptic Syndrome

  • Epilepsies

  • Symptomatic Epilepsies

  • Post Traumatic Epilepsy

  • Traumatic Epilepsy

  • Traumatic Epileptic

  • Epilepsy Due To Hippocampal Sclerosis

  • Epilepsy With Ammon'S Horn Sclerosis

  • Epilepsy Due To Cortical Dysplasia

  • Epilepsy Due To Neuronal Migration Disorders
Leukoencephalopathy With Vanishing White Matter

  • Cree Leukoencephalopathy

  • Vanishing White Matter Disease

  • Ovarioleukodystrophy

  • Vanishing White Matter Leukodystrophy

  • Childhood Ataxia With Central Nervous System Hypomyelinization

  • Cach

  • Cach Syndrome

  • Myelinosis Centralis Diffusa

  • VWM

  • Cle

  • Childhood Ataxia With Central Nervous System Hypomyelination

  • Childhood Ataxia With Diffuse Central Nervous System Hypomyelination

  • Cach/Vwm

  • Cach/Vwm Syndrome

  • Childhood Ataxia With Central Nervous System Hypomyelination/Vanishing White Matter

  • Cree Leukoencehalopathy

  • Late Infantile Cach Syndrome

  • Juvenile Or Adult Cach Syndrome

  • Congenital Or Early Infantile Cach Syndrome

  • Leukodystrophy With Vanishing White Matter
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00179 ACOT7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22373 Acot7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ACOT7 RGD RGD:628856
Canis familiaris ACOT7 VGNC VGNC:53259
Felis catus ACOT7 VGNC VGNC:82524
Macaca mulatta ACOT7 VGNC VGNC:99835
Mus musculus ACOT7 MGD MGI:1917275
Others ACOT7 NCBI