ANK2 - ankyrin 2 Gene

Also Known as LQT4; ANK-2; FAP87; CFAP87; brank-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 287

About ANK2

Cytogenetic location: 4q25-q26 Genomic coordinates (GRCh38): 4:112,705,622-113,383,736 (from NCBI)

This gene has 129 transcripts (splice variants), 236 orthologues, 3 paralogues and is associated with 3 phenotypes. Biased expression in brain (RPKM 29.6), kidney (RPKM 21.6) and 13 other tissues.

Summary

This gene encodes a member of the ankyrin family of proteins that link the integral membrane proteins to the underlying spectrin-actin Cytoskeleton. Ankyrins play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. The protein encoded by this gene is required for targeting and stability of Na/CA exchanger 1 in cardiomyocytes. Mutations in this gene cause long QT syndrome 4 and cardiac arrhythmia syndrome. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Dec 2011]

ANK2 Products (73)

mRNA	Protein	Name
NM_001127493.3	NP_001120965.1	ankyrin-2 isoform 3
NM_001148.6	NP_001139.3	ankyrin-2 isoform 1
NM_001354225.2	NP_001341154.1	ankyrin-2 isoform 4
NM_001354228.2	NP_001341157.1	ankyrin-2 isoform 5
NM_001354230.2	NP_001341159.1	ankyrin-2 isoform 6
NM_001354231.2	NP_001341160.1	ankyrin-2 isoform 7
NM_001354232.2	NP_001341161.1	ankyrin-2 isoform 8
NM_001354235.2	NP_001341164.1	ankyrin-2 isoform 9
NM_001354236.2	NP_001341165.1	ankyrin-2 isoform 10
NM_001354237.2	NP_001341166.1	ankyrin-2 isoform 11
NM_001354239.2	NP_001341168.1	ankyrin-2 isoform 12
NM_001354240.2	NP_001341169.1	ankyrin-2 isoform 13
NM_001354241.2	NP_001341170.1	ankyrin-2 isoform 14
NM_001354242.2	NP_001341171.1	ankyrin-2 isoform 15
NM_001354243.2	NP_001341172.1	ankyrin-2 isoform 16
NM_001354244.2	NP_001341173.1	ankyrin-2 isoform 17
NM_001354245.2	NP_001341174.1	ankyrin-2 isoform 18
NM_001354246.2	NP_001341175.1	ankyrin-2 isoform 19
NM_001354249.2	NP_001341178.1	ankyrin-2 isoform 20
NM_001354252.2	NP_001341181.1	ankyrin-2 isoform 21
NM_001354253.2	NP_001341182.1	ankyrin-2 isoform 22
NM_001354254.2	NP_001341183.1	ankyrin-2 isoform 23
NM_001354255.2	NP_001341184.1	ankyrin-2 isoform 24
NM_001354256.2	NP_001341185.1	ankyrin-2 isoform 25
NM_001354257.2	NP_001341186.1	ankyrin-2 isoform 26
NM_001354258.2	NP_001341187.1	ankyrin-2 isoform 27
NM_001354260.2	NP_001341189.1	ankyrin-2 isoform 28
NM_001354261.2	NP_001341190.1	ankyrin-2 isoform 29
NM_001354262.2	NP_001341191.1	ankyrin-2 isoform 30
NM_001354264.2	NP_001341193.1	ankyrin-2 isoform 31
NM_001354265.2	NP_001341194.1	ankyrin-2 isoform 32
NM_001354266.2	NP_001341195.1	ankyrin-2 isoform 33
NM_001354267.2	NP_001341196.1	ankyrin-2 isoform 33
NM_001354268.2	NP_001341197.1	ankyrin-2 isoform 35
NM_001354269.3	NP_001341198.1	ankyrin-2 isoform 36
NM_001354270.2	NP_001341199.1	ankyrin-2 isoform 37
NM_001354271.2	NP_001341200.1	ankyrin-2 isoform 38
NM_001354272.2	NP_001341201.1	ankyrin-2 isoform 39
NM_001354273.2	NP_001341202.1	ankyrin-2 isoform 40
NM_001354274.2	NP_001341203.1	ankyrin-2 isoform 41
NM_001354275.2	NP_001341204.1	ankyrin-2 isoform 42
NM_001354276.2	NP_001341205.1	ankyrin-2 isoform 43
NM_001354277.2	NP_001341206.1	ankyrin-2 isoform 44
NM_001354278.2	NP_001341207.1	ankyrin-2 isoform 45
NM_001354279.2	NP_001341208.1	ankyrin-2 isoform 46
NM_001354280.2	NP_001341209.1	ankyrin-2 isoform 47
NM_001354281.2	NP_001341210.1	ankyrin-2 isoform 48
NM_001354282.2	NP_001341211.1	ankyrin-2 isoform 49
NM_001386142.1	NP_001373071.1	ankyrin-2 isoform 50
NM_001386143.1	NP_001373072.1	ankyrin-2 isoform 51
NM_001386144.1	NP_001373073.1	ankyrin-2 isoform 52
NM_001386146.1	NP_001373075.1	ankyrin-2 isoform 53
NM_001386147.1	NP_001373076.1	ankyrin-2 isoform 54
NM_001386148.2	NP_001373077.1	ankyrin-2 isoform 55
NM_001386149.1	NP_001373078.1	ankyrin-2 isoform 56
NM_001386150.1	NP_001373079.1	ankyrin-2 isoform 57
NM_001386151.1	NP_001373080.1	ankyrin-2 isoform 58
NM_001386152.1	NP_001373081.1	ankyrin-2 isoform 59
NM_001386153.1	NP_001373082.1	ankyrin-2 isoform 60
NM_001386154.1	NP_001373083.1	ankyrin-2 isoform 61
NM_001386156.1	NP_001373085.1	ankyrin-2 isoform 62
NM_001386157.1	NP_001373086.1	ankyrin-2 isoform 63
NM_001386158.1	NP_001373087.1	ankyrin-2 isoform 64
NM_001386160.1	NP_001373089.1	ankyrin-2 isoform 71
NM_001386161.1	NP_001373090.1	ankyrin-2 isoform 25
NM_001386162.1	NP_001373091.1	ankyrin-2 isoform 43
NM_001386166.1	NP_001373095.1	ankyrin-2 isoform 65
NM_001386167.1	NP_001373096.1	ankyrin-2 isoform 66
NM_001386174.1	NP_001373103.1	ankyrin-2 isoform 67
NM_001386175.1	NP_001373104.1	ankyrin-2 isoform 68
NM_001386186.2	NP_001373115.1	ankyrin-2 isoform 69
NM_001386187.2	NP_001373116.1	ankyrin-2 isoform 70
NM_020977.5	NP_066187.2	ankyrin-2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	21177872	GOA
enables phosphorylation-dependent protein binding	IPI IPI: Inferred from physical interaction	25950943	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15262991	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	18782775	GOA
enables spectrin binding	IPI IPI: Inferred from physical interaction	15262991	GOA
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	20610380	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in SA node cell to atrial cardiac muscle cell communication	IMP IMP: Inferred from mutant phenotype	12571597	GOA
involved in atrial cardiac muscle cell action potential	IMP IMP: Inferred from mutant phenotype	17242276	GOA
involved in atrial septum development	IMP IMP: Inferred from mutant phenotype	18832177	GOA
involved in positive regulation of gene expression	IGI IGI: Inferred from genetic interaction	17242276	GOA
involved in protein localization	IGI IGI: Inferred from genetic interaction	15262991	GOA
involved in protein localization to endoplasmic reticulum	IGI IGI: Inferred from genetic interaction	15178757	GOA
involved in protein localization to organelle	IGI IGI: Inferred from genetic interaction	15178757	GOA
involved in protein localization to plasma membrane	IGI IGI: Inferred from genetic interaction	17178715	GOA
involved in regulation of SA node cell action potential	IMP IMP: Inferred from mutant phenotype	12571597	GOA
involved in regulation of atrial cardiac muscle cell action potential	IMP IMP: Inferred from mutant phenotype	12571597	GOA
involved in regulation of calcium ion transport	IGI IGI: Inferred from genetic interaction	12571597	GOA
involved in regulation of cardiac muscle cell contraction	IGI IGI: Inferred from genetic interaction	17242276	GOA
involved in regulation of cardiac muscle contraction	IMP IMP: Inferred from mutant phenotype	15178757	GOA
involved in regulation of cardiac muscle contraction by calcium ion signaling	IMP IMP: Inferred from mutant phenotype	12571597	GOA
involved in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	IGI IGI: Inferred from genetic interaction	17178715	GOA
involved in regulation of heart rate	IMP IMP: Inferred from mutant phenotype	18832177	GOA
involved in regulation of heart rate by cardiac conduction	IMP IMP: Inferred from mutant phenotype	12571597	GOA
involved in regulation of release of sequestered calcium ion into cytosol	IGI IGI: Inferred from genetic interaction	17242276	GOA
involved in regulation of ventricular cardiac muscle cell membrane repolarization	IMP IMP: Inferred from mutant phenotype	18832177	GOA
involved in ventricular cardiac muscle cell action potential	IMP IMP: Inferred from mutant phenotype	17242276	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	15611082	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANK2 Protein Structure

Ank_2

Ank_4

Ank_2

Ank_4

Ank_2

Ank

Ank_2

ZU5

Death

0
700
1400
2100
2800
3500
3957 a.a.

Protein Preferred Names	Protein Names
ankyrin-2	ankyrin 2, neuronal

ANK2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ANK2	Q01484	DMD	Homo sapiens	P11532-5	Pull Down	19109891
Intra	ANK2	Q01484	RRBP1	Homo sapiens	Q9P2E9	Crosslink	30021884
Intra	ANK2	Q01484	RRBP1	Homo sapiens	Q9P2E9	Anti Bait CoIP	36950384
Intra	ANK2	Q01484	KCNJ11	Homo sapiens	Q14654	Anti Bait CoIP	19805355
Intra	ANK2	Q01484	EHD3	Homo sapiens	Q9NZN3	Pull Down	20489164
Intra	ANK2	Q01484	EHD3	Homo sapiens	Q9NZN3	Y2H	20489164
Intra	ANK2	Q01484	DYNC1H1	Homo sapiens	Q14204	Anti Bait CoIP	36950384
Intra	ANK2	Q01484	ACOT7	Homo sapiens	O00154	Crosslink	26949739

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Cardiac Arrhythmia, Ankyrin-B-Related	Long Qt Syndrome 4 Ankyrin-B Syndrome LQT4 Ankyrin-B-Related Cardiac Arrhythmia Sick Sinus Syndrome With Bradycardia Arrhythmia, Cardiac, Ankyrin B-Related
Long Qt Syndrome 1	Romano-Ward Syndrome LQT1 Ward-Romano Syndrome Rws Ventricular Fibrillation With Prolonged Qt Interval Wrs Long Qt Syndrome 1, Acquired, Susceptibility To Long Qt Syndrome 1, Acquired Romano-Ward Long Qt Syndrome Long Qt Syndrome Type 1 Long Qt Syndrome-1 Acquired Susceptibility To Long Qt Syndrome 1 Qt Syndrome, Long, Type 1
Long Qt Syndrome	Romano-Ward Syndrome Long Q-T Syndrome Lqt Qt Syndrome, Long Congenital Long Qt Syndrome Familial Long Qt Syndrome
Ventricular Tachycardia, Catecholaminergic Polymorphic, 1, With Or Without Atrial Dysfunction And/Or Dilated Cardiomyopathy	Catecholaminergic Polymorphic Ventricular Tachycardia 1 Ventricular Tachycardia, Catecholaminergic Polymorphic, 1 CPVT1 Ventricular Tachycardia, Stress-Induced Polymorphic Vtsip Bidirectional Tachycardia Stress-Induced Polymorphic Ventricular Tachycardia Cvpt1 Double Tachycardia Induced By Catecholamines Malignant Paroxysmal Ventricular Tachycardia Multifocal Ventricular Premature Beats Paroxysmal Ventricular Fibrillation Syncopal Paroxysmal Tachycardia Syncopal Tachyarythmia Ventricular Tachycardia Catecholaminergic Polymorphic 1 Tachycardia, Ventricular, Catecholaminergic Polymorphic, Type 1 Multifocal Pvcs Multifocal Premature Ventricular Beats Paroxysmal Familial Ventricular Fibrillation Catecholaminergic Polymorphic Ventricular Tachycardia Type 1
Catecholaminergic Polymorphic Ventricular Tachycardia	Cpvt Catecholamine-Induced Polymorphic Ventricular Tachycardia Familial Polymorphic Ventricular Tachycardia Malignant Paroxysmal Ventricular Tachycardia Multifocal Ventricular Premature Beats Stress-Induced Polymorphic Ventricular Tachycardia Bidirectional Tachycardia Induced By Catecholamine Double Tachycardia Induced By Catecholamines Polymorphic Catecholergic Ventricular Tachycardia Syncopal Paroxysmal Tachycardia Bidirectional Tachycardia Induced By Catecholamines Fpvt Bidirectional Ventricular Tachycardia Induced By Catecholamine Polymorphic Ventricular Tachycardia Induced By Catecholamines Ventricular Tachycardia, Catecholaminergic Polymorphic Ventricular Tachycardia, Catecholaminergic Polymorphic, 1 Familial Ventricular Tachycardia Multifocal Pvcs Multifocal Premature Ventricular Beats
Atrial Fibrillation	A-Fib Fibrillation, Atrial Af - [Atrial Fibrillation] Rapid Atrial Fibrillation A Fib - [Atrial Fibrillation]
Long Qt Syndrome 6	LQT6 Long Qt Syndrome 3/6 Lqt3/6 Susceptibility To Acquired Long Qt Syndrome 6 Long Qt Syndrome-6 Long Qt Syndrome 6, Acquired, Susceptibility To Qt Syndrome, Long, Type 6 Long Qt Syndrome 3-6
Long Qt Syndrome 5	LQT5 Long Qt Syndrome 2/5 Lqt2/5 Susceptibility To Acquired Long Qt Syndrome 5 Long Qt Syndrome-5 Long Qt Syndrome 5, Acquired, Susceptibility To Qt Syndrome, Long, Type 5 Long Qt Syndrome 2-5
Long Qt Syndrome 9	LQT9 Long Qt Syndrome-9 Qt Syndrome, Long, Type 9
Long Qt Syndrome 12	LQT12 Qt Syndrome, Long, Type 12
Long Qt Syndrome 11	LQT11 Long Qt Syndrome-11 Qt Syndrome, Long, Type 11
Long Qt Syndrome 10	LQT10 Atrial Fibrillation, Familial, 17 ATFB17 Long Qt Syndrome-10 Qt Syndrome, Long, Type 10
Long Qt Syndrome 3	LQT3 Long Qt Syndrome Type 3 Long Qt Syndrome-3 Qt Syndrome, Long, Type 3
Legionnaire Disease	Legionnaires' Disease Legionnaires Disease Legionnaire Disease, Susceptibility To Legionella Legionella Pneumonia Infection By Legionella Pneumophilia Legionnaire'S Disease Legionellosis Legionaire Disease, Susceptibility To Legionnaires Pneumonia
Sinoatrial Node Disease	Sa Node Sinuatrial Node Sinus Node Dysfunction
Andersen Cardiodysrhythmic Periodic Paralysis	Andersen Syndrome Andersen-Tawil Syndrome LQT7 Long Qt Syndrome 7 Ats Periodic Paralysis, Potassium-Sensitive Cardiodysrhythmic Type Long Qt Syndrome Type 7 Andersen Tawil Syndrome Potassium-Sensitive Cardiodysrhythmic Type Lqts Type 7 Long Qt Syndrome-7
Long Qt Syndrome 2	LQT2 Long Qt Syndrome, Acquired, Reduced Susceptibility To Long Qt Syndrome 1/2 Long Qt Syndrome 2/3 Long Qt Syndrome 2/5 Long Qt Syndrome 2, Acquired, Susceptibility To Long Qt Syndrome, Acquired, Reduced Long Qt Syndrome Type 2 Long Qt Syndrome 2/9 Lqt1/2 Lqt2/3 Lqt2/5 Lqt2/9 Susceptibility To Acquired Long Qt Syndrome 2 Long Qt Syndrome-2 Qt Syndrome, Long, Type 2 Long Qt Syndrome 1-2 Long Qt Syndrome 2-3 Long Qt Syndrome 2-5 Long Qt Syndrome 9
Spinocerebellar Ataxia 5	Spinocerebellar Ataxia Type 5 SCA5 Spinocerebellar Ataxia-5 Ataxia, Spinocerebellar, Type 5
Long Qt Syndrome 13	LQT13 Qt Syndrome, Long, Type 13
Brugada Syndrome 3	BRGDA3 Brugada Syndrome, Type 3
Progressive Familial Heart Block, Type Ia	PFHB1A Bundle Branch Block Heart Block, Nonprogressive Lenegre-Lev Disease Hereditary Bundle Branch System Defect Progressive Familial Heart Block Type Ia Pfhbia Pccd Hbbd Progressive Familial Heart Block, Type 1a Heart Block, Progressive Familial, Type I Pfhbi Cardiac Conduction Defect, Progressive Heart Block, Progressive, Type Ia Progressive Familial Heart Block Type 1a Familial Progressive Cardiac Conduction Defect Heart Block Progressive Familial Type 1 Familial Lenègre Disease Familial Lev Disease Familial Lev-Lenègre Disease Familial Pccd Familial Progressive Heart Block Hereditary Bundle Branch Defect Progressive Familial Heart Block Progressive Familial Heart Block 1a Cardiac Conduction Defect Progressive Cardiac Conduction Defect Progressive Familial Heart Block Type I Heart Block, Progressive, Familial, Type 1a Bundle-Branch Block Conduction Disorder Of The Heart
Legionellosis	Legionella Infection Pontiac Fever Legionnaires' Disease Infection By Legionella Pneumophilia Legionella Pneumophila Infection
Timothy Syndrome	Long Qt Syndrome With Syndactyly TS Lqt8 Long Qt Syndrome 8 Long Qt Syndrome Type 8 Long Qt Syndrome-Syndactyly Syndrome
Pontiac Fever
Cardiomyopathy, Familial Hypertrophic, 4	Hypertrophic Cardiomyopathy 4 CMH4 Cardiomyopathy, Hypertrophic, 4 Cardiomyopathy, Familial Hypertrophic 4 Cardiomyopathy, Familial Hypertrophic, 4, Susceptibility To Cardiomyopathy, Hypertrophic, Familial, Type 4
Ventricular Tachycardia, Catecholaminergic Polymorphic, 3	Catecholaminergic Polymorphic Ventricular Tachycardia 3 CPVT3 Cvpt3 Tachycardia, Ventricular, Catecholaminergic Polymorphic, Type 3
Short Qt Syndrome	Sqts Familial Short Qt Syndrome
Sick Sinus Syndrome	Sinus Node Dysfunction Sinus Node Disease Sinus Node Infection Snd Sss Snd - [Sinus Node Dysfunction] Sinoatrial Node Dysfunction Sss - [Sick Sinus Syndrome] Sick Sinus Sick Sinus Tachycardia
Coffin-Siris Syndrome 1	Coffin-Siris Syndrome Fifth Digit Syndrome Css CSS1 Mrd12 Mental Retardation, Autosomal Dominant 12 Hhid Dwarfism-Onychodysplasia Hypertrichosis, Hyperkeratosis, Mental Retardation, And Distinctive Facial Features Autosomal Dominant Mental Retardation 12 Short Stature-Onychodysplasia. Intellectual Disability With Absent Fifth Fingernail And Terminal Phalanx Mental Retardation With Hypoplastic Fifth Fingernails And Toenails Short Stature-Onychodysplasia Coffin-Siris Syndrome, Type 1 Mental Retardation, Autosomal Dominant, Type 12
Jervell And Lange-Nielsen Syndrome 1	Jervell And Lange-Nielsen Syndrome Jervell-Lange Nielsen Syndrome Prolonged Qt Interval In Ekg And Sudden Death Cardioauditory Syndrome Of Jervell And Lange-Nielsen Surdo-Cardiac Syndrome JLNS1 Deafness, Congenital, And Functional Heart Disease Jlns Long Qt Interval-Deafness Syndrome Jervell And Lange-Nielson Syndrome Jervell Lange-Nielsen Syndrome Autosomal Recessive Long Qt Syndrome Cardio-Auditory-Syncope Syndrome Long Qt Interval-Hearing Loss Syndrome Congenital Deafness And Functional Heart Disease Long Qt Interval-Deafness
Mitochondrial Dna Depletion Syndrome 3	Deoxyguanosine Kinase Deficiency Mitochondrial Dna Depletion Syndrome, Hepatocerebral Form MTDPS3 Dguok Deficiency Dguok-Related Mitochondrial Dna Depletion Syndrome, Hepatocerebral Form Dguok-Related Mitochondrial Dna Depletion Syndrome Hepatocerebral Mitochondrial Dna Depletion Syndrome Mtdna Depletion Syndrome, Hepatocerebral Form Mitochondrial Dna Depletion Syndrome, Hepatocerebral Form Due To Dguok Deficiency Hepatocerebral Mitochondrial Dna Deletions Syndrome Autosomal Recessive Mitochondrial Dna Depletion Syndrome 3 Hepatocerebral Type Mitochondrial Dna Depletion Syndrome , Type 3
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Intrinsic Cardiomyopathy
Hereditary Spherocytosis	Congenital Spherocytic Hemolytic Anemia Spherocytic Anemia Congenital Spherocytosis Spherocytosis, Type 1 Minkowski Chauffard Syndrome Hs Minkowski-Chauffard Disease Minkowski-Chauffard Syndrome Spherocytosis Hereditary Spherocytosis, Hereditary Anemia, Hereditary Spherocytic Hemolytic
Heart Conduction Disease	Conduction Disorder Of The Heart Heart Rhythm Disease
Brugada Syndrome	Sudden Unexpected Nocturnal Death Syndrome Sudden Unexplained Nocturnal Death Syndrome Bangungut Brugada Type Idiopathic Ventricular Fibrillation Pokkuri Death Syndrome Sunds Idiopathic Ventricular Fibrillation, Brugada Type Sudden Unexplained Death Dream Disease Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome Sudden Unexplained Death Syndrome Suds Sunds - [Sudden Unexplained Nocturnal Death Syndrome]
Alcohol Dependence	Alcoholism Alcohol Dependence, Susceptibility To Alcohol Dependence, Protection Against Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against Alcoholism, Susceptibility To Alcoholic Intoxication, Chronic Pharyngeal Neoplasms Chronic Alcoholism Dipsomania Alcohol Addiction Ethanol Dependence Chronic Ethanolism Chronic Alcoholic Disease Nos Alcoholic Disease Nos Alcoholic
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Familial Atrial Fibrillation	Atrial Fibrillation, Familial Atfb Atrial Fibrillation Autosomal Dominant Autosomal Dominant Atrial Fibrillation Auricular Fibrillation Atrial Fibrillation Atrial Fibrillation, Familial, 1
Arrhythmogenic Right Ventricular Cardiomyopathy	Arrhythmogenic Right Ventricular Dysplasia Arvc Arvd Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy Arvc Cardiomyopathy Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia Arvd/C Right Ventricular Dysplasia, Arrhythmogenic Ventricular Dysplasia, Right, Arrhythmogenic Cardiomyopathy, Ventricular, Right, Arrhythmogenic Dysplasia, Arrhythmogenic Right Ventricular
Left Ventricular Noncompaction	Noncompaction Cardiomyopathy Left Ventricular Hypertrabeculation Lvnc Spongy Myocardium Isolated Noncompaction Of The Ventricular Myocardium Left Ventricular Myocardial Noncompaction Cardiomyopathy Fetal Myocardium Honeycomb Myocardium Hypertrabeculation Syndrome Left Ventricular Non-Compaction Lvht Non-Compaction Of The Left Ventricular Myocardium Ventricular Noncompaction, Left Non-Compaction Cardiomyopathy
Generalized Epilepsy With Febrile Seizures Plus	Gefs+ Genetic Epilepsy With Febrile Seizures Plus Generalized Epilepsy With Febrile Seizures-Plus Genetic Epilepsy With Febrile Seizures-Plus Epilepsy, Generalized, With Febrile Seizures Plus
Hypertrophic Cardiomyopathy	Hypertrophic Obstructive Cardiomyopathy Cardiomyopathy, Hypertrophic Cardiomyopathy Hypertrophic Obstructive Cardiomyopathy, Hypertrophic, Familial Idiopathic Myocardial Hypertrophy Idiopathic Hypertrophic Cardiomyopathy Obstructive Idiopathic Hypertrophic Cardiomyopathy Obstructive Cardiomyopathy Idiopathic Hypertrophic Subaortic Stenosis Muscular Subaortic Stenosis Hypertrophic Obstructive Subaortic Stenosis
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00700	ANK2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ANK2	MGD	MGI:88025
Felis catus	ANK2	VGNC	VGNC:107310
Rattus norvegicus	ANK2	RGD	RGD:620156
Macaca mulatta	ANK2	VGNC	VGNC:100200
Others	ANK2	NCBI