EHD3 - EH domain containing 3 Gene

Also Known as PAST3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 30845

About EHD3

Cytogenetic location: 2p23.1 Genomic coordinates (GRCh38): 2:31,234,152-31,269,451 (from NCBI)

This gene has 1 transcript (splice variant), 217 orthologues and 10 paralogues. Broad expression in brain (RPKM 25.4), esophagus (RPKM 14.7) and 17 other tissues.

Summary

Predicted to enable nucleic acid binding activity. Involved in several processes, including Golgi to lysosome transport; endosomal transport; and protein homooligomerization. Acts upstream of or within protein localization to plasma membrane and regulation of cardiac muscle cell membrane potential. Located in ciliary pocket membrane and recycling endosome membrane. [provided by Alliance of Genome Resources, Apr 2022]

EHD3 Products (1)

mRNA	Protein	Name
NM_014600.3	NP_055415.1	EH domain-containing protein 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15020713	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Golgi to lysosome transport	IMP IMP: Inferred from mutant phenotype	19139087	GOA
involved in cilium assembly	IMP IMP: Inferred from mutant phenotype	25686250	GOA
involved in early endosome to Golgi transport	IMP IMP: Inferred from mutant phenotype	19139087	GOA
involved in endocytic recycling	IDA IDA: Inferred from direct assay	17233914	GOA
involved in protein homooligomerization	IPI IPI: Inferred from physical interaction	17233914	GOA
acts upstream of or within protein localization to plasma membrane	IGI IGI: Inferred from genetic interaction	20489164	GOA
involved in receptor recycling	IMP IMP: Inferred from mutant phenotype	21791287	GOA
involved in regulation of Golgi organization	IMP IMP: Inferred from mutant phenotype	19139087	GOA
acts upstream of or within regulation of cardiac muscle cell membrane potential	IGI IGI: Inferred from genetic interaction	20489164	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in ciliary pocket membrane	IDA IDA: Inferred from direct assay	25686250	GOA
located in recycling endosome membrane	IDA IDA: Inferred from direct assay	17233914	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EHD3 Protein Structure

Dynamin_N

EF-hand_4

0
100
200
300
400
500
535 a.a.

Protein Preferred Names	Protein Names
EH domain-containing protein 3	PAST homolog 3

EHD3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	EHD3	Q9NZN3	MICALL1	Homo sapiens	Q8N3F8	Y2H	27189942
Intra	EHD3	Q9NZN3	MICALL1	Homo sapiens	Q8N3F8	ITC	27189942
Intra	EHD3	Q9NZN3	ANKFY1	Homo sapiens	Q9P2R3	Y2H	27189942
Intra	EHD3	Q9NZN3	EHD1	Homo sapiens	Q9H4M9	Y2H Prey Pooling	32296183
Intra	EHD3	Q9NZN3	EHD1	Homo sapiens	Q9H4M9	IF	26226295
Intra	EHD3	Q9NZN3	EHD1	Homo sapiens	Q9H4M9	Y2H Array	32296183
Intra	EHD3	Q9NZN3	EHD1	Homo sapiens	Q9H4M9	Anti Tag CoIP	33961781
Intra	EHD3	Q9NZN3	EHD1	Homo sapiens	Q9H4M9	Anti Tag CoIP	26226295
Cross	EHD3	Q9NZN3	Ehd3	Mus musculus	Q9QXY6	IF	26226295
Cross	EHD3	Q9NZN3	Ehd3	Mus musculus	Q9QXY6	Anti Tag CoIP	26226295

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS28674	Ehd3 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	EHD3	MGD	MGI:1928900
Rattus norvegicus	EHD3	RGD	RGD:621762
Canis familiaris	EHD3	VGNC	VGNC:40247
Bos taurus	EHD3	VGNC	VGNC:28373
Macaca mulatta	EHD3	VGNC	VGNC:72176
Felis catus	EHD3	VGNC	VGNC:61765
Others	EHD3	NCBI