THAP1 Antibody (YA4530)(PBS only)

Cat. No.: HY-P84833A: Data Sheet User Guide for Antibodies
FAQs
Technical Support

THAP1 Antibody (YA4530) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to THAP1.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

* Please select Quantity before adding items.

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

THAP1 Antibody (YA4530) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to THAP1.

Host

Mouse

Molecular Weight

Predicted band size: 24.9 kDa;

Observed band size: 25-30 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

Q9NVV9

Gene ID

55145 [NCBI]

Immunogen

Purified recombinant fragment of human THAP1 (AA: 1-213) expressed in E. Coli.

Application &
Dilution Ratio

Application	Dilution Ratio
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:200-1:1000
FC FC: Flow Cytometry	1:200-1:400
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:10000

Purity	affinity purified.	Conjugation	Non-conjugated
Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptotic activity by potentiating both serum-withdrawal and TNF-induced apoptosis

Subcellular Localization：Nucleus, nucleoplasm; Nucleus, PML body

Expression：
Tissue_specificity:Highly expressed in heart, skeletal muscle, kidney and liver. Weaker expression in brain and placenta

Isoforms & Post-Translational Modification：Q9NVV9 has 2 isomers: Q9NVV9-1: 24944 Da (predicted); Q9NVV9-2: 6493 Da (predicted).

Subunit：Homodimer (PubMed:28299530). Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter (PubMed:12717420, PubMed:20144952, PubMed:20200153)

Synonyms

DYT6

Documentation

User Guide for Antibodies (1077 KB)