PF-06455943

Cat. No.: HY-148353: FAQs
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PF-06455943 is a leucine rich repeat kinase 2 (LRRK2) inhibitor with IC₅₀ value of 3 nM. PF-06455943 also is a PET radioligand. PF-06455943 can be used for the research of ADME/neuro PK characterization and Parkinson disease (PD).

For research use only. We do not sell to patients.

PF-06455943 Chemical Structure

CAS No. : 1527474-15-2

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Description	PF-06455943 is a leucine rich repeat kinase 2 (LRRK2) inhibitor with IC₅₀ value of 3 nM. PF-06455943 also is a PET radioligand. PF-06455943 can be used for the research of ADME/neuro PK characterization and Parkinson disease (PD)^[1]^[2].
In Vitro	PF-06455943 (Compound 22) has inhibition activity for LRRK2 with IC₅₀ values of 3 nM (WT), 9 nM (G2019S) and 20 nM (cellular WCA), respectively^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. PF-06455943 Related Antibodies
Molecular Weight	323.32
Formula	C₁₇H₁₄FN₅O
CAS No.	1527474-15-2
SMILES	N#CC1=CC=CC(C2=CNC3=NC=NC(N4CCOCC4)=C32)=C1F
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (275 KB) Handling Instructions (2659 KB)
References	[1]. Zhen Chen, et al. Imaging Leucine-Rich Repeat Kinase 2 In Vivo with 18F-Labeled Positron Emission Tomography Ligand. J Med Chem. 2022 Oct 18. [Content Brief] [2]. Jaclyn L Henderson, et al. Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. J Med Chem. 2015 Jan 8;58(1):419-32. [Content Brief]

PF-06455943 Related Classifications

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-064559431527474-15-2PF06455943PF 06455943LRRK2Leucine-rich repeat kinase 2leucine rich repeat kinase 2 (LRRK2)Parkinson disease (PD)receptor-interacting protein (RIP)Inhibitorinhibitorinhibit

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PF-06455943

PF-06455943 Related Antibodies

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