2. Autophagy
  3. LRRK2
  4. PF-06455943

PF-06455943 is a leucine rich repeat kinase 2 (LRRK2) inhibitor with IC50 value of 3 nM. PF-06455943 also is a PET radioligand. PF-06455943 can be used for the research of ADME/neuro PK characterization and Parkinson disease (PD).

For research use only. We do not sell to patients.

PF-06455943

PF-06455943 Chemical Structure

CAS No. : 1527474-15-2

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 mg In-stock
10 mg In-stock
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Based on 1 publication(s) in Google Scholar

PF-06455943 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

PF-06455943 is a leucine rich repeat kinase 2 (LRRK2) inhibitor with IC50 value of 3 nM. PF-06455943 also is a PET radioligand. PF-06455943 can be used for the research of ADME/neuro PK characterization and Parkinson disease (PD)[1][2].

Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
20 nM
Compound: 22
Inhibition of full length LRRK2 (unknown origin) expressed in HEK293 cells assessed as reduction in S935 phosphorylation incubated for 90 mins by ELISA method
Inhibition of full length LRRK2 (unknown origin) expressed in HEK293 cells assessed as reduction in S935 phosphorylation incubated for 90 mins by ELISA method
[PMID: 25353650]
In Vitro

PF-06455943 (Compound 22) has inhibition activity for LRRK2 with IC50 values of 3 nM (WT), 9 nM (G2019S) and 20 nM (cellular WCA), respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PF-06455943 Related Antibodies
Molecular Weight

323.32

Formula

C17H14FN5O
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

N#CC1=CC=CC(C2=CNC3=NC=NC(N4CCOCC4)=C32)=C1F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (38.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0929 mL 15.4646 mL 30.9291 mL
5 mM 0.6186 mL 3.0929 mL 6.1858 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0929 mL 15.4646 mL 30.9291 mL 77.3228 mL
5 mM 0.6186 mL 3.0929 mL 6.1858 mL 15.4646 mL
10 mM 0.3093 mL 1.5465 mL 3.0929 mL 7.7323 mL
15 mM 0.2062 mL 1.0310 mL 2.0619 mL 5.1549 mL
20 mM 0.1546 mL 0.7732 mL 1.5465 mL 3.8661 mL
25 mM 0.1237 mL 0.6186 mL 1.2372 mL 3.0929 mL
30 mM 0.1031 mL 0.5155 mL 1.0310 mL 2.5774 mL
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PF-06455943 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-064559431527474-15-2PF06455943PF 06455943LRRK2Leucine-rich repeat kinase 2leucine rich repeat kinase 2 (LRRK2)Parkinson disease (PD)receptor-interacting protein (RIP)Inhibitorinhibitorinhibit

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