1527474-15-2
1527474-15-2
Chemical Structure
PF-06455943
- CAS No.: 1527474-15-2
- Formula:C17H14FN5O
- Molecular Weight:323.32
IUPAC Name: 2-fluoro-3-(4-morpholino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile
InChIKey: YIDVVQGSCVWPGO-UHFFFAOYSA-N
SMILES: N#CC1=CC=CC(C2=CNC3=NC=NC(N4CCOCC4)=C32)=C1F
Biological Activity: PF-06455943 is a leucine rich repeat kinase 2 (LRRK2) inhibitor with IC50 value of 3 nM. PF-06455943 also is a PET radioligand. PF-06455943 can be used for the research of ADME/neuro PK characterization and Parkinson disease (PD)[1][2].
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PF-06455943 | 98.21% | PF-06455943 is a leucine rich repeat kinase 2 (LRRK2) inhibitor with IC50 value of 3 nM. PF-06455943 also is a PET radioligand. PF-06455943 can be used for the research of ADME/neuro PK characterization and Parkinson disease (PD). | ||||||||||||||||||||
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References
- [1]. Zhen Chen, et al. Imaging Leucine-Rich Repeat Kinase 2 In Vivo with 18F-Labeled Positron Emission Tomography Ligand. J Med Chem. 2022 Oct 18. [Content Brief]
- [2]. Jaclyn L Henderson, et al. Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. J Med Chem. 2015 Jan 8;58(1):419-32. [Content Brief]
Keywords
