RAB10 - RAB10, member RAS oncogene family Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10890

About RAB10

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:26,033,285-26,137,454 (from NCBI)

This gene has 4 transcripts (splice variants), 215 orthologues and 68 paralogues. Ubiquitous expression in esophagus (RPKM 102.3), colon (RPKM 40.9) and 25 other tissues.

Summary

RAB10 belongs to the Ras (see HRAS; MIM 190020) superfamily of small GTPases. RAB proteins localize to exocytic and endocytic compartments and regulate intracellular vesicle trafficking (Bao et al., 1998 [PubMed 9918381]).[supplied by OMIM, Mar 2009]

RAB10 Products (1)

mRNA	Protein	Name
NM_016131.5	NP_057215.3	ras-related protein Rab-10

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GDP binding	IDA IDA: Inferred from direct assay	20937701	GOA
enables GTP binding	IDA IDA: Inferred from direct assay	20937701	GOA
enables myosin V binding	IPI IPI: Inferred from physical interaction	22908308	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in antigen processing and presentation	IMP IMP: Inferred from mutant phenotype	19717423	GOA
involved in endoplasmic reticulum tubular network organization	IMP IMP: Inferred from mutant phenotype	23263280	GOA
involved in endosomal transport	IMP IMP: Inferred from mutant phenotype	16641372	GOA
involved in establishment of protein localization to endoplasmic reticulum membrane	IMP IMP: Inferred from mutant phenotype	23263280	GOA
involved in establishment of protein localization to membrane	IMP IMP: Inferred from mutant phenotype	24006491	GOA
involved in regulated exocytosis	IMP IMP: Inferred from mutant phenotype	2732579	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	23263280	GOA
located in cilium	IDA IDA: Inferred from direct assay	20576682	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	23263280	GOA
located in endoplasmic reticulum tubular network	IDA IDA: Inferred from direct assay	23263280	GOA
located in endosome	IDA IDA: Inferred from direct assay	20576682	GOA
located in endosome membrane	IDA IDA: Inferred from direct assay	32344433	GOA
located in exocytic vesicle	IDA IDA: Inferred from direct assay	18504258	GOA
located in insulin-responsive compartment	IDA IDA: Inferred from direct assay	22908308	GOA
colocalizes with plasma membrane	IDA IDA: Inferred from direct assay	22908308	GOA
located in recycling endosome	IDA IDA: Inferred from direct assay	16641372	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB10 Protein Structure

Ras

0
100
200 a.a.

Protein Preferred Names	Protein Names
ras-related protein Rab-10	GTP-binding protein RAB10

RAB10 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RAB10	P61026	RAB39A	Homo sapiens	Q14964	Crosslink	30021884
Intra	RAB10	P61026	RAB39A	Homo sapiens	Q14964	Anti Tag CoIP	26824392
Intra	RAB10	P61026	LRRK2	Homo sapiens	Q5S007	Anti Tag CoIP	26824392
Intra	RAB10	P61026	RILPL2	Homo sapiens	Q969X0	Anti Tag CoIP	32017888
Intra	RAB10	P61026	OPTN	Homo sapiens	Q96CV9	Y2H Prey Pooling	25416956
Intra	RAB10	P61026	OPTN	Homo sapiens	Q96CV9	Y2H Array	25416956
Intra	RAB10	P61026	OPTN	Homo sapiens	Q96CV9	Validated Y2H	25416956
Intra	RAB10	P61026	PPM1H	Homo sapiens	Q9ULR3	Anti Tag CoIP	31663853

Cross: Cross-species interaction Intra: Intraspecies interaction

RAB10 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82044	Rab10 Antibody (YA1789)	WB, ICC/IF, IP	Human, Mouse, Rat
HY-P82044A	Rab10 Antibody (YA1789)(PBS only)	WB, ICC/IF, IP	Human, Mouse, Rat
HY-P84420	Rab10 Antibody (YA4117)	WB, ICC/IF, ELISA	Human, Mouse
HY-P84420A	Rab10 Antibody (YA4117)(PBS only)	WB, ICC/IF, ELISA	Human, Mouse
HY-P85342	Rab10 Antibody (YA5034)	WB, ICC/IF, ELISA	Human, Mouse

Related Diseases

Diseases	Alias
Carpenter Syndrome 1	Carpenter Syndrome Acrocephalopolysyndactyly Type Ii Acps Ii CRPT1 Acrocephalopolysyndactyly Type 2 Acrocephalosyndactyly, Type Ii Acrocephalopolysyndactyly 2 Acps2 Acps 2 Type Ii Acrocephalosyndactyly Carpenter Syndrome, Type 1 Apert-Crouzon Disease
Microvillus Inclusion Disease	Congenital Microvillous Atrophy Intractable Diarrhea Of Infancy Congenital Familial Protracted Diarrhea With Enterocyte Brush-Border Abnormalities Davidson Disease Microvillous Inclusion Disease Congenital Microvillus Atrophy Mvid Diarrhea 2 With Microvillus Atrophy Mvd Congenital Familial Protracted Diarrhea Davidson'S Disease Familial Enteropathy, Microvillus Microvillus Atrophy, Congenital Congenital Enteropathy Familial Protracted Enteropathy Microvillous Atrophy Microvillus Atrophy With Diarrhea 2 Idi
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Warburg Micro Syndrome 1	Warburg Micro Syndrome Micro Syndrome Warbm WARBM1 Warburg Sjo Fledelius Syndrome Warburg-Sjo-Fledelius Syndrome Micro Syndrome 1 Microcephaly, Microcornea, Congenital Cataract, Intellectual Disability, Optic Atrophy And Hypogenitalism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11514	RAB10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21710	Rab10 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-180320	Lu AF58786	Inhibitor	/	Unkown
HY-184198	LRRK2-IN-22	Inhibitor	/	Unkown
HY-RS28228	Rab10 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RAB10	VGNC	VGNC:106202
Rattus norvegicus	RAB10	RGD	RGD:620879
Canis familiaris	RAB10	VGNC	VGNC:45247
Felis catus	RAB10	VGNC	VGNC:81163
Mus musculus	RAB10	MGD	MGI:105066
Bos taurus	RAB10	VGNC	VGNC:33613
Others	RAB10	NCBI