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製品番号: HY-184198

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LRRK2-IN-22

LRRK2-IN-22 is a LRRK2 inhibitor, with IC₅₀ values of 315.7 nM and 255.4 nM against LRRK2^WT and LRRK2^G2019S, respectively. LRRK2-IN-22 effectively inhibits LRRK2 kinase activity and downstream Rab10 phosphorylation, reduces ROS, and exhibits low cytotoxicity. LRRK2-IN-22 can be used for research on Parkinson's disease.

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CAS 番号: 1427947-55-4
分子式: C₂₁H₂₁N₃O₂
分子量:347.41

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

LRRK2-IN-22 構造式

CAS 番号: 1427947-55-4

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

LRRK2-IN-22 (Compound C-298) (0-10 μM; 24 h) exhibits low cytotoxicity in untransfected HEK293T cells, with an IC₅₀ of 3273 nM after 24 h of treatment^[1].
LRRK2-IN-22 (1-10 μM; 24 h) potently and dose-dependently inhibits ROS production, and its effect is stronger in HEK293T cells overexpressing LRRK2^G2019S than in cells overexpressing wild-type (WT) LRRK2^[1].
LRRK2-IN-22 (30-10000 nM; 4 h) potently and dose-dependently inhibits the phosphorylation of LRRK2 (Ser935) and Rab10 (Thr73), and exhibits higher potency against the LRRK2^G2019S mutant than wild-type LRRK2 in HEK293T cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

HEK293T cells overexpressing WT or G2019S mutant LRRK2
Concentration:

30, 100, 300, 1000, 3000 and 10000 nM
Incubation Time:

4 h
Result:

Suppressed phosphorylation of LRRK2 at Ser935 and Rab10 at Thr73 in a dose-dependent manner.
Inhibited pSer935-LRRK2 with an IC₅₀ of 341.4 nM in WT LRRK2-overexpressing cells and 226.7 nM in G2019S LRRK2-overexpressing cells.
Inhibited pThr73-Rab10 with an IC₅₀ of 425.7 nM in WT LRRK2-overexpressing cells and 231.2 nM in G2019S LRRK2-overexpressing cells.

化学情報

CAS 番号 1427947-55-4
分子量 347.41
分子式 C₂₁H₂₁N₃O₂
SMILES

COC1=CC=C(CC(N2CC=C(C3=CNC4=C3C=CC=N4)CC2)=O)C=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Gong X, et al. A Multistage Virtual Screening Strategy Integrating Molecular Similarity, Deep Learning Scoring, and Molecular Docking toward the Discovery of Novel LRRK2 Inhibitors. J Chem Inf Model. 2026;66(11):6706-6718. [Content Brief]

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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