1427947-55-4
1427947-55-4
Chemical Structure
LRRK2-IN-22
- CAS No.: 1427947-55-4
- Formula:C21H21N3O2
- Molecular Weight:347.41
InChIKey: CVXCVVAXZRDYLE-UHFFFAOYSA-N
SMILES: COC1=CC=C(CC(N2CC=C(C3=CNC4=C3C=CC=N4)CC2)=O)C=C1
Biological Activity: LRRK2-IN-22 is a LRRK2 inhibitor, with IC50 values of 315.7 nM and 255.4 nM against LRRK2WT and LRRK2G2019S, respectively. LRRK2-IN-22 effectively inhibits LRRK2 kinase activity and downstream Rab10 phosphorylation, reduces ROS, and exhibits low cytotoxicity. LRRK2-IN-22 can be used for research on Parkinson's disease[1].
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LRRK2-IN-22 | LRRK2-IN-22 is a LRRK2 inhibitor, with IC50 values of 315.7 nM and 255.4 nM against LRRK2WT and LRRK2G2019S, respectively. LRRK2-IN-22 effectively inhibits LRRK2 kinase activity and downstream Rab10 phosphorylation, reduces ROS, and exhibits low cytotoxicity. LRRK2-IN-22 can be used for research on Parkinson's disease. | |||||||||||||||||||||
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References
Keywords
