RAB39A - RAB39A, member RAS oncogene family Gene

Also Known as K28; RAB39

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 54734

About RAB39A

Cytogenetic location: 11q22.3 Genomic coordinates (GRCh38): 11:107,928,448-107,963,482 (from NCBI)

This gene has 1 transcript (splice variant), 208 orthologues and 68 paralogues. Broad expression in brain (RPKM 2.3), appendix (RPKM 1.8) and 16 other tissues.

Summary

Predicted to enable GTPase activity. Involved in phagosome acidification and phagosome-lysosome fusion. Located in phagocytic vesicle. [provided by Alliance of Genome Resources, Apr 2022]

RAB39A Products (1)

mRNA Protein Name
NM_017516.3 NP_059986.1 ras-related protein Rab-39A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
24349490 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in phagosome acidification IMP
IMP: Inferred from mutant phenotype
21255211 GOA
involved in phagosome-lysosome fusion IMP
IMP: Inferred from mutant phenotype
21255211 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in phagocytic vesicle IDA
IDA: Inferred from direct assay
21255211 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB39A Protein Structure

Ras

Ras: Ras family (10 - 176)

  • 0
  • 100
  • 200
  • 217 a.a.
Protein Preferred Names Protein Names

ras-related protein Rab-39A

  • RAB39, member RAS oncogene family

RAB39A Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
RAB39A Q14964 BLZF1 Homo sapiens Q9H2G9
Y2H Array
32296183
Intra
RAB39A Q14964 BLZF1 Homo sapiens Q9H2G9
Validated Y2H
25416956
Intra
RAB39A Q14964 BLZF1 Homo sapiens Q9H2G9
Validated Y2H
32296183
Intra
RAB39A Q14964 BLZF1 Homo sapiens Q9H2G9
Y2H Prey Pooling
25416956
Intra
RAB39A Q14964 BLZF1 Homo sapiens Q9H2G9
Y2H Prey Pooling
32296183
Intra
RAB39A Q14964 BLZF1 Homo sapiens Q9H2G9
Y2H Array
25416956
Intra
RAB39A Q14964 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
RAB39A Q14964 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
RAB39A Q14964 GOLGA2 Homo sapiens Q08379
Validated Y2H
25416956
Intra
RAB39A Q14964 GOLGA2 Homo sapiens Q08379
Y2H Array
25416956
Intra
RAB39A Q14964 GORASP2 Homo sapiens Q9H8Y8
Y2H Prey Pooling
32296183
Intra
RAB39A Q14964 GORASP2 Homo sapiens Q9H8Y8
Validated Y2H
32296183
Intra
RAB39A Q14964 GORASP2 Homo sapiens Q9H8Y8
Y2H Array
32296183
Intra
RAB39A Q14964 BECN1 Homo sapiens Q14457
Anti Tag CoIP
24349490
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Waisman Syndrome

  • Early-Onset Parkinsonism-Intellectual Disability Syndrome

  • Bgmr

  • Wsn

  • Laxova-Opitz Syndrome

  • WSMN

  • Parkinsonism, Early-Onset, With Mental Retardation

  • Basal Ganglion Disorder With Mental Retardation

  • Basal Ganglia Disorder With Intellectual Disability

  • Laxova Brown Hogan Syndrome

  • X-Linked Recessive Basal Ganglia Disorder With Intellectual Disability
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS11553 RAB39A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Felis catus RAB39A VGNC VGNC:104319
Bos taurus RAB39A VGNC VGNC:33647
Mus musculus RAB39A MGD MGI:2442855
Macaca mulatta RAB39A VGNC VGNC:81537
Rattus norvegicus RAB39A RGD RGD:1311286
Others RAB39A NCBI