PPM1H - protein phosphatase, Mg2+/Mn2+ dependent 1H Gene

Also Known as URCC2; ARHCL1; NERPP-2C

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57460

About PPM1H

Cytogenetic location: 12q14.1-q14.2 Genomic coordinates (GRCh38): 12:62,643,994-62,935,150 (from NCBI)

This gene has 5 transcripts (splice variants), 282 orthologues and 16 paralogues. Broad expression in brain (RPKM 7.7), prostate (RPKM 6.7) and 23 other tissues.

Summary

Enables identical protein binding activity and phosphoprotein Phosphatase activity. Predicted to be involved in protein dephosphorylation. Located in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PPM1H Products (1)

mRNA Protein Name
NM_020700.2 NP_065751.1 protein phosphatase 1H

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables phosphoprotein phosphatase activity IMP
IMP: Inferred from mutant phenotype
22586611 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
31663853 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
22586611 GOA
located in nucleus IDA
IDA: Inferred from direct assay
22586611 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPM1H Protein Structure

PP2C

PP2C: Protein phosphatase 2C (240 - 314)

PP2C

PP2C: Protein phosphatase 2C (379 - 458)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 514 a.a.
Protein Preferred Names Protein Names

protein phosphatase 1H

  • neurite extension-related protein phosphatase related to PP2C

PPM1H Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PPM1H Q9ULR3 RAB10 Homo sapiens P61026
Phosphatase Assay
31663853
Intra
PPM1H Q9ULR3 RAB10 Homo sapiens P61026
Anti Tag CoIP
31663853
Intra
PPM1H Q9ULR3 RAB10 Homo sapiens P61026
Confocal
31663853
Intra
PPM1H Q9ULR3 YWHAB Homo sapiens P31946
Anti Tag CoIP
27880917
Intra
PPM1H Q9ULR3 PPM1H Homo sapiens Q9ULR3
Validated Y2H
32296183
Intra
PPM1H Q9ULR3 PPM1H Homo sapiens Q9ULR3
Y2H Array
32296183
Intra
PPM1H Q9ULR3 PPM1J Homo sapiens Q5JR12
Anti Tag CoIP
27880917
Intra
PPM1H Q9ULR3 PPM1J Homo sapiens Q5JR12
Anti Tag CoIP
31663853
Intra
PPM1H Q9ULR3 YWHAH Homo sapiens Q04917
Anti Tag CoIP
27880917
Intra
PPM1H Q9ULR3 YWHAG Homo sapiens P61981
Anti Tag CoIP
27880917
Intra
PPM1H Q9ULR3 PPM1H Homo sapiens Q9ULR3
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Multiple Endocrine Neoplasia, Type Iv

  • Multiple Endocrine Neoplasia Type 4

  • MEN4

  • Multiple Endocrine Neoplasia 4

  • Neoplasia, Endocrine, Multiple, Type Iv
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10966 PPM1H Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22737 Ppm1h Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29251 Ppm1h Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PPM1H RGD RGD:1309528
Macaca mulatta PPM1H VGNC VGNC:76060
Canis familiaris PPM1H VGNC VGNC:44868
Mus musculus PPM1H MGD MGI:2442087
Felis catus PPM1H VGNC VGNC:64312
Bos taurus PPM1H VGNC VGNC:33214
Others PPM1H NCBI