PPM1H - protein phosphatase, Mg2+/Mn2+ dependent 1H Gene

Homo sapiens

Also known as URCC2; ARHCL1; NERPP-2C

Gene ID: 57460 | Gene type: protein coding

About PPM1H

Cytogenetic location: 12q14.1-q14.2 Genomic coordinates (GRCh38): 12:62,643,994-62,935,150 (from NCBI)

This gene has 5 transcripts (splice variants), 282 orthologues and 16 paralogues. Broad expression in brain (RPKM 7.7), prostate (RPKM 6.7) and 23 other tissues.

Summary

Enables identical protein binding activity and phosphoprotein Phosphatase activity. Predicted to be involved in protein dephosphorylation. Located in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PPM1H Products(1)

mRNA	Protein	Name
NM_020700.2	NP_065751.1	protein phosphatase 1H

PPM1H Protein Structure

PP2C

0
100
200
300
400
514 a.a.

Protein Preferred Names

Protein Names

protein phosphatase 1H

neurite extension-related protein phosphatase related to PP2C

Related Diseases

Diseases

Alias

Multiple Endocrine Neoplasia, Type Iv

Multiple Endocrine Neoplasia Type 4	MEN4
Multiple Endocrine Neoplasia 4	Neoplasia, Endocrine, Multiple, Type Iv

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10966	PPM1H Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PPM1H	RGD	RGD:1309528
Macaca mulatta	PPM1H	VGNC	VGNC:76060
Canis familiaris	PPM1H	VGNC	VGNC:44868
Mus musculus	PPM1H	MGD	MGI:2442087
Felis catus	PPM1H	VGNC	VGNC:64312
Bos taurus	PPM1H	VGNC	VGNC:33214
Others	PPM1H	NCBI

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