RAB5B - RAB5B, member RAS oncogene family Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5869

About RAB5B

Cytogenetic location: 12q13.2 Genomic coordinates (GRCh38): 12:55,973,949-55,996,683 (from NCBI)

This gene has 11 transcripts (splice variants), 135 orthologues and 68 paralogues. Ubiquitous expression in brain (RPKM 35.5), esophagus (RPKM 35.2) and 25 other tissues.

Summary

Enables GDP binding activity; GTP-dependent protein binding activity; and GTPase activity. Involved in antigen processing and presentation and plasma membrane to endosome transport. Located in endosome and extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

RAB5B Products (5)

mRNA Protein Name
NM_001252036.2 NP_001238965.1 ras-related protein Rab-5B isoform 1
NM_001252037.2 NP_001238966.1 ras-related protein Rab-5B isoform 2
NM_001414457.1 NP_001401386.1 ras-related protein Rab-5B isoform 1
NM_001414458.1 NP_001401387.1 ras-related protein Rab-5B isoform 3
NM_002868.4 NP_002859.1 ras-related protein Rab-5B isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GDP binding IDA
IDA: Inferred from direct assay
20937701 GOA
enables GTP-dependent protein binding IDA
IDA: Inferred from direct assay
10491193 GOA
enables GTPase activity IDA
IDA: Inferred from direct assay
17562788 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10491193 GOA
Biological Process GO Annotation Evidence References Source
involved in antigen processing and presentation IMP
IMP: Inferred from mutant phenotype
19717423 GOA
involved in plasma membrane to endosome transport IMP
IMP: Inferred from mutant phenotype
17562788 GOA
Cellular Component GO Annotation Evidence References Source
located in endosome IDA
IDA: Inferred from direct assay
10491193 GOA
located in extracellular exosome IDA
IDA: Inferred from direct assay
15326289 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB5B Protein Structure

Ras

Ras: Ras family (22 - 181)

  • 0
  • 100
  • 200
  • 215 a.a.
Protein Preferred Names Protein Names

ras-related protein Rab-5B

RAB5B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RAB5B P61020 EEA1 Homo sapiens Q15075
Y2H
10491193
Intra
RAB5B P61020 EEA1 Homo sapiens Q15075
IF
10491193
Intra
RAB5B P61020 LRRK2 Homo sapiens Q5S007
GTPase Assay
25605758
Intra
RAB5B P61020 LRRK2 Homo sapiens Q5S007
Y2H
18445495
Intra
RAB5B P61020 LRRK2 Homo sapiens Q5S007
Protein Kinase Assay
25605758
Intra
RAB5B P61020 LRRK2 Homo sapiens Q5S007
Anti Bait CoIP
18445495
Cross: Cross-species interaction Intra: Intraspecies interaction

RAB5B Antibodies

Cat. No. Product Name Application Reactivity
HY-P810815 RAB5B Antibody (YA10058) WB Human, Mouse

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11572 RAB5B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21716 Rab5b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28234 Rab5b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RAB5B MGD MGI:105938
Bos taurus RAB5B VGNC VGNC:33659
Macaca mulatta RAB5B VGNC VGNC:81546
Rattus norvegicus RAB5B RGD RGD:1306489
Canis familiaris RAB5B VGNC VGNC:45292
Felis catus RAB5B VGNC VGNC:97593
Others RAB5B NCBI