RAB5B Antibody (YA10058)
(Synonyms: TXGP1; Tumor necrosis factor ligand superfamily member 4; Glycoprotein Gp34; OX40 ligand; OX40L; TAX transcriptionally-activated glycoprotein 1; CD252)RAB5B Antibody (YA10058) is a Mouse-derived and non-conjugated IgG1 Monoclonal antibody, targeting to RAB5B.
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Host:
Mouse
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human, Mouse
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:1000-2000 |
Product Details
RAB5B Antibody (YA10058) is a Mouse-derived and non-conjugated IgG1 Monoclonal antibody, targeting to RAB5B.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse
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Observed Molecular WeightObserved band size: 24 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 23 kDa
Purified recombinant protein of human RAB5B.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
RAB5B is a The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Involved in early endocytic trafficking. Required for EEA1 recruitment to early endosomes. Required for EGF and transferrin endocytosis and trafficking through early endosomes[1][2].
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Subcellular Localization
Cell membrane; Early endosome membrane; Melanosome
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Isoforms & Post-Translational Modification
RAB5B has 2 isoforms, P61020-1: amino acid length is 215, molecular weight is 23707 Da (predicted); P61020-2: amino acid length is 174, molecular weight is 19090 Da (predicted).
Phosphorylation of Ser-84 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2. -
Subunit
Interacts with EEA1.
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SwissProt ID
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Synonyms
TXGP1; Tumor necrosis factor ligand superfamily member 4; Glycoprotein Gp34; OX40 ligand; OX40L; TAX transcriptionally-activated glycoprotein 1; CD252
Documentation
[1]. Haas AK, et al. A GTPase-activating protein controls Rab5 function in endocytic trafficking. Nat Cell Biol. 2005 Sep;7(9):887-93. [Content Brief]
[2]. Fuchs E, et al. Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways. J Cell Biol. 2007 Jun 18;177(6):1133-43. [Content Brief]
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