EEA1 - early endosome antigen 1 Gene

Also Known as MST105; ZFYVE2; MSTP105

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8411

About EEA1

Cytogenetic location: 12q22 Genomic coordinates (GRCh38): 12:92,770,637-92,929,295 (from NCBI)

This gene has 5 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in esophagus (RPKM 9.9), fat (RPKM 8.8) and 25 other tissues.

Summary

Enables 1-phosphatidylinositol binding activity; GTP-dependent protein binding activity; and protein homodimerization activity. Involved in endocytosis; vesicle fusion; and viral RNA genome replication. Located in cytosol and early endosome. Is extrinsic component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

EEA1 Products (1)

mRNA	Protein	Name
NM_003566.4	NP_003557.3	early endosome antigen 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 1-phosphatidylinositol binding	IDA IDA: Inferred from direct assay	11256955	GOA
enables GTP-dependent protein binding	IDA IDA: Inferred from direct assay	10491193	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9697774	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	11741531	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in endocytosis	IMP IMP: Inferred from mutant phenotype	21081650	GOA
involved in modulation by host of viral process	IMP IMP: Inferred from mutant phenotype	19376974	GOA
involved in vesicle fusion	IMP IMP: Inferred from mutant phenotype	9697774	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	7768953	GOA
located in early endosome	IDA IDA: Inferred from direct assay	11741531	GOA
located in early endosome membrane	IDA IDA: Inferred from direct assay	7768953	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
early endosome antigen 1	early endosome antigen 1, 162kD

EEA1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	EEA1	Q15075	RAB5C	Homo sapiens	P51148	SPR	25114243
Intra	EEA1	Q15075	RAB5C	Homo sapiens	P51148	Confocal	25266290
Intra	EEA1	Q15075	SAMD9	Homo sapiens	Q5K651	Anti Tag CoIP	24029230
Intra	EEA1	Q15075	ZFYVE16	Homo sapiens	Q7Z3T8	BioID	29568061
Intra	EEA1	Q15075	RAB5B	Homo sapiens	P61020	Pull Down	10491193
Intra	EEA1	Q15075	RAB5A	Homo sapiens	P20339	Pull Down	16902405
Intra	EEA1	Q15075	RAB5A	Homo sapiens	P20339	Pull Down	11870209
Intra	EEA1	Q15075	RAB22A	Homo sapiens	Q9UL26	Pull Down	11870209
Intra	EEA1	Q15075	RAB22A	Homo sapiens	Q9UL26	Y2H	11870209
Intra	EEA1	Q15075	ERBB2	Homo sapiens	P04626	Anti Bait CoIP	16314522
Cross	EEA1	Q15075	Stx6	Rattus norvegicus	Q63635	Pull Down	10506127

Cross: Cross-species interaction Intra: Intraspecies interaction

EEA1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80114	EEA1 Antibody (YA777)	WB, IHC-P	Human, Mouse, Rat
HY-P86603	EEA1 Antibody (YA6295)	WB, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Subacute Cutaneous Lupus Erythematosus	Lupus Erythematosus Cutaneous Subacute Lupus Erythematosus, Subacute Cutaneous Sacle - [Subacute Cutaneous Lupus Erythematosus] Scle - [Subacute Cutaneous Lupus Erythematosus]
Cutaneous Lupus Erythematosus	Lupus Erythematosus, Cutaneous Lupus Erythematosus Cutaneous
Oculoglandular Tularemia
Human Monocytic Ehrlichiosis	Ehrlichiosis Chafeensis Hme Human Ehrlichial Infection, Human Monocytic Type
Human Granulocytic Anaplasmosis	Human Granulocytic Ehrlichiosis Hge Human Ehrlichial Infection, Human Granulocytic Type Human Anaplasmosis Due To Anaplasma Phagocytophilum
Dystonia	Dystonic Disease Dystonic Disorder Dystonia Disorders Neuroleptic Dyskinesia
Hermansky-Pudlak Syndrome	Hps Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells Hermanski-Pudlak Syndrome Hermansky Pudlak Syndrome Platelet Storage Pool Deficiency
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Hereditary Spastic Paraplegia	Familial Spastic Paraplegia Hereditary Spastic Paraparesis Strumpell-Lorrain Disease Familial Spastic Paraparesis Hsp Spg Strümpell-Lorrain Disease Spastic Paraplegia, Hereditary French Settlement Disease Strumpell-Lorrain Syndrome Fsp Spastic Paraplegia, Familial Spastic Paraplegia Hereditary Spastic Paraplegia 3, Autosomal Dominant Spastic Paraparesis Hereditary Spastic Paralysis Familial Spastic Paralysis Hereditary Spastic Ataxia
Charcot-Marie-Tooth Disease	Cmt Hmsn Hereditary Motor And Sensory Neuropathy Pma Cmt - Charcot-Marie-Tooth Disease Charcot Marie Tooth Disease Charcot-Marie-Tooth Hereditary Neuropathy Charcot-Marie-Tooth Syndrome Peroneal Muscular Atrophy Hereditary Motor And Sensory Neuropathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-150058	Bocconoline		≥95.0%	Unkown
HY-RS04172	EEA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-148965A	PtdIns-(3)-P1 (1,2-dipalmitoyl) ammonium		/	Unkown
HY-RS19326	Eea1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25817	Eea1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	EEA1	VGNC	VGNC:54421
Felis catus	EEA1	VGNC	VGNC:61730
Mus musculus	EEA1	MGD	MGI:2442192
Rattus norvegicus	EEA1	RGD	RGD:1310167
Canis familiaris	EEA1	VGNC	VGNC:40205
Macaca mulatta	EEA1	VGNC	VGNC:72161
Others	EEA1	NCBI