RAB5C - RAB5C, member RAS oncogene family Gene

Also Known as RABL; L1880; RAB5L; RAB5CL

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5878

About RAB5C

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:42,124,979-42,154,989 (from NCBI)

This gene has 9 transcripts (splice variants), 274 orthologues and 68 paralogues. Ubiquitous expression in kidney (RPKM 55.2), bone marrow (RPKM 47.2) and 25 other tissues.

Summary

Members of the Rab protein family are small GTPases of the Ras superfamily that are thought to ensure fidelity in the process of docking and/or fusion of vesicles with their correct acceptor compartment (Han et al., 1996 [PubMed 8646882]).[supplied by OMIM, Nov 2010]

RAB5C Products (3)

mRNA Protein Name
NM_001252039.2 NP_001238968.1 ras-related protein Rab-5C isoform b
NM_004583.4 NP_004574.2 ras-related protein Rab-5C isoform a
NM_201434.3 NP_958842.1 ras-related protein Rab-5C isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables GDP binding IDA
IDA: Inferred from direct assay
20937701 GOA
enables GTPase activity IDA
IDA: Inferred from direct assay
17562788 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17562788 GOA
Biological Process GO Annotation Evidence Références Source
involved in plasma membrane to endosome transport IMP
IMP: Inferred from mutant phenotype
17562788 GOA
Cellular Component GO Annotation Evidence Références Source
located in lipid droplet IDA
IDA: Inferred from direct assay
14741744 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB5C Protein Structure

Ras

Ras: Ras family (23 - 182)

  • 0
  • 100
  • 200
  • 216 a.a.
Protein Preferred Names Protein Names

ras-related protein Rab-5C

  • RAB5C, member of RAS oncogene family

RAB5C Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
RAB5C P51148 ALS2CL Homo sapiens Q60I27
Y2H Prey Pooling
32296183
Intra
RAB5C P51148 ALS2CL Homo sapiens Q60I27
Y2H Array
32296183
Intra
RAB5C P51148 ALS2CL Homo sapiens Q60I27
Validated Y2H
32296183
Intra
RAB5C P51148 EEA1 Homo sapiens Q15075
Pull Down
25266290
Intra
RAB5C P51148 APPL2 Homo sapiens Q8NEU8
Validated Y2H
32296183
Intra
RAB5C P51148 APPL2 Homo sapiens Q8NEU8
Validated Y2H
25416956
Intra
RAB5C P51148 APPL2 Homo sapiens Q8NEU8
Y2H Prey Pooling
32296183
Intra
RAB5C P51148 APPL2 Homo sapiens Q8NEU8
Y2H Array
32296183
Intra
RAB5C P51148 APPL2 Homo sapiens Q8NEU8
Y2H Array
25416956
Intra
RAB5C P51148 APPL2 Homo sapiens Q8NEU8
Y2H Array
31515488
Intra
RAB5C P51148 APPL2 Homo sapiens Q8NEU8
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

RAB5C Anticorps

Cat. No. Nom du produit Application Reactivity
HY-P80294 RAB5C Antibody (YA111) WB, IHC-P Human

Related Diseases

Diseases Alias
Argentine Hemorrhagic Fever

  • Argentinian Hemorrhagic Fever

  • Junin Hemorrhagic Fever

  • Hemorrhagic Fever, Argentinian

  • Ahf - [Argentinian Haemorrhagic Fever]

  • Argentine Haemorrhagic Fever

  • Junin Haemorrhagic Fever
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS11573 RAB5C Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus RAB5C VGNC VGNC:99428
Rattus norvegicus RAB5C RGD RGD:1307095
Canis familiaris RAB5C VGNC VGNC:55798
Bos taurus RAB5C VGNC VGNC:50253
Mus musculus RAB5C MGD MGI:105306
Others RAB5C NCBI