RAB5C Antibody (YA111)
RAB5C Antibody (YA111) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RAB5C.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human
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Formulation:
Supplied in 1*TBS (pH7.4), 0.05% BSA and 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:100-1:400 |
Product Details
RAB5C Antibody (YA111) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RAB5C.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 23 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 23 kDa
Synthetic peptide corresponding to Human RAB5C.AA range:1-216.
Endogenous
Protein A affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 1*TBS (pH7.4), 0.05% BSA and 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion
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Subcellular Localization
Cell membrane; Lipid-anchor; Cytoplasmic side; Early endosome membrane; Lipid-anchor; Melanosome
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Isoforms & Post-Translational Modification
P51148 has 2 isomers: P51148-1: 23483 Da (predicted); P51148-2: 27036 Da (predicted).
Phosphorylation of Ser-85 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2;(Microbial infection) Glycosylated on arginine residues by S.typhimurium protein Ssek3 -
Subunit
Interacts with EEA1 (PubMed:12493736). Interacts with INCA1 (PubMed:21750715). Interacts with GDI1, GDI2, CHML and CHM; phosphorylation at Ser-85 disrupts this interaction (PubMed:29125462)
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SwissProt ID
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Research Field
Signal Transduction
Documentation
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