ZFYVE16 - zinc finger FYVE-type containing 16 Gene

Also Known as PPP1R69

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9765

About ZFYVE16

Cytogenetic location: 5q14.1 Genomic coordinates (GRCh38): 5:80,407,610-80,483,379 (from NCBI)

This gene has 13 transcripts (splice variants), 95 orthologues and 13 paralogues. Ubiquitous expression in brain (RPKM 10.1), endometrium (RPKM 9.9) and 25 other tissues.

Summary

This gene encodes an endosomal protein that belongs to the FYVE zinc finger family of proteins. The encoded protein is thought to regulate membrane trafficking in the endosome. This protein functions as a scaffold protein in the transforming growth factor-beta signaling pathway and is involved in positive and negative feedback regulation of the bone morphogenetic protein signaling pathway. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

ZFYVE16 Products (5)

mRNA Protein Name
NM_001105251.4 NP_001098721.2 zinc finger FYVE domain-containing protein 16 isoform a
NM_001284236.3 NP_001271165.2 zinc finger FYVE domain-containing protein 16 isoform a
NM_001284237.2 NP_001271166.2 zinc finger FYVE domain-containing protein 16 isoform b
NM_001349434.2 NP_001336363.2 zinc finger FYVE domain-containing protein 16 isoform a
NM_014733.6 NP_055548.4 zinc finger FYVE domain-containing protein 16 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 1-phosphatidylinositol binding IDA
IDA: Inferred from direct assay
11546807 GOA
enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
IDA: Inferred from direct assay
11433298 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
14613930 GOA
Biological Process GO Annotation Evidence References Source
involved in endosomal transport IMP
IMP: Inferred from mutant phenotype
11546807 GOA
involved in protein targeting to lysosome IMP
IMP: Inferred from mutant phenotype
11546807 GOA
Cellular Component GO Annotation Evidence References Source
located in early endosome IDA
IDA: Inferred from direct assay
11546807 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZFYVE16 Protein Structure

FYVE

FYVE: FYVE zinc finger (743 - 805)

DUF3480

DUF3480: Domain of unknown function (DUF3480) (1167 - 1515)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1539 a.a.
Protein Preferred Names Protein Names

zinc finger FYVE domain-containing protein 16

  • endosome-associated FYVE-domain protein

ZFYVE16 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZFYVE16 Q7Z3T8 EEA1 Homo sapiens Q15075
Density Sedimentation
14613930
Intra
ZFYVE16 Q7Z3T8 PPP1CA Homo sapiens P62136
Y2H
15231748
Intra
ZFYVE16 Q7Z3T8 TOM1 Homo sapiens O60784
Pull Down
14613930
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Arteriovenous Malformations Of The Brain

  • Cerebral Arteriovenous Malformation

  • Intracranial Arteriovenous Malformation

  • Intracranial Hemorrhage In Brain Cerebrovascular Malformations, Susceptibility To

  • Intracranial Arteriovenous Malformations

  • Bavm

  • Cerebral Arteriovenous Malformations

  • Intracranial Hemorrhage In Brain Cerebrovascular Malformations

  • Arteriovenous Malformation Of The Brain, Somatic

  • Intracranial Avm

  • Arteriovenous Malformations Cerebral
Gluten Allergy

  • Allergy To Gluten

  • Gluten Allergic Reaction
Psoriasis 14, Pustular

  • Generalized Pustular Psoriasis

  • Gpp

  • Ditra

  • Acrodermatitis Continua Of Hallopeau

  • Palmoplantar Pustulosis

  • PSORS14

  • Interleukin 36 Receptor Antagonist Deficiency

  • Psorp

  • Pustular Psoriasis 14

  • Deficiency Of Il-36r Antagonist

  • Acute Generalised Pustular Psoriasis

  • Deficiency Of The Interleukin-36 Receptor Antagonist

  • Generalized Pustular Psoriasis Of Von Zumbusch

  • Von Zumbusch Psoriasis

  • Deficiency Of Il-36ra

  • Psoriasis, Pustular, Generalized

  • Psoriasis, Pustular, Type 14

  • Pustulosis Of Palms And Soles

  • Acute Generalized Pustular Psoriasis

  • Palmoplantar Pustular Psoriasis

  • Pustulosis Palmaris Et Plantaris

  • Ppp - [Palmoplantar Pustulosis]

  • Pustular Psoriasis Of The Palms And Soles

  • Pustular Bacterid
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16056 ZFYVE16 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ZFYVE16 VGNC VGNC:79281
Mus musculus ZFYVE16 MGD MGI:2145181
Canis familiaris ZFYVE16 VGNC VGNC:48623
Bos taurus ZFYVE16 VGNC VGNC:37174
Rattus norvegicus ZFYVE16 RGD RGD:1564784
Felis catus ZFYVE16 VGNC VGNC:67238
Others ZFYVE16 NCBI