TOM1 - target of myb1 membrane trafficking protein Gene

Also Known as IMD85

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10043

About TOM1

Cytogenetic location: 22q12.3 Genomic coordinates (GRCh38): 22:35,299,275-35,347,973 (from NCBI)

This gene has 18 transcripts (splice variants), 221 orthologues, 10 paralogues and is associated with 2 phenotypes. Ubiquitous expression in bone marrow (RPKM 24.4), esophagus (RPKM 24.1) and 25 other tissues.

Summary

This gene was identified as a target of the v-myb oncogene. The encoded protein shares its N-terminal domain in common with proteins associated with vesicular trafficking at the endosome. It is recruited to the endosomes by its interaction with endofin. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

TOM1 Products (4)

mRNA	Protein	Name
NM_001135729.2	NP_001129201.1	target of Myb1 membrane trafficking protein isoform 3
NM_001135730.2	NP_001129202.1	target of Myb1 membrane trafficking protein isoform 4
NM_001135732.2	NP_001129204.1	target of Myb1 membrane trafficking protein isoform 2
NM_005488.3	NP_005479.1	target of Myb1 membrane trafficking protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables clathrin binding	IDA IDA: Inferred from direct assay	16412388	GOA
enables clathrin heavy chain binding	IDA IDA: Inferred from direct assay	14563850	GOA
enables myosin VI binding	IDA IDA: Inferred from direct assay	23023224	GOA
enables phosphatidylinositol-5-phosphate binding	IDA IDA: Inferred from direct assay	25588840	GOA
enables polyubiquitin modification-dependent protein binding	IDA IDA: Inferred from direct assay	14563850	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14563850	GOA
enables ubiquitin binding	IDA IDA: Inferred from direct assay	16199040	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in autophagosome-lysosome fusion	IMP IMP: Inferred from mutant phenotype	23023224	GOA
involved in endosomal transport	IDA IDA: Inferred from direct assay	14563850	GOA
involved in positive regulation of autophagosome maturation	IMP IMP: Inferred from mutant phenotype	23023224	GOA
involved in regulation of endosome organization	IDA IDA: Inferred from direct assay	25588840	GOA
involved in substrate localization to autophagosome	IMP IMP: Inferred from mutant phenotype	23023224	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	14563850	GOA
located in cytosol	IDA IDA: Inferred from direct assay	14613930	GOA
located in early endosome	IDA IDA: Inferred from direct assay	14613930	GOA
located in endosome	IDA IDA: Inferred from direct assay	15047686	GOA
located in endosome membrane	IDA IDA: Inferred from direct assay	23023224	GOA
located in membrane	IDA IDA: Inferred from direct assay	14613930	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TOM1 Protein Structure

VHS

GAT

0
100
200
300
400
492 a.a.

Protein Preferred Names	Protein Names
target of Myb1 membrane trafficking protein target of Myb protein 1	target of myb 1

Protein Preferred Names

Protein Names

target of Myb1 membrane trafficking protein

target of Myb protein 1

target of myb 1

TOM1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TOM1	O60784	TOLLIP	Homo sapiens	Q6FIE9	Validated Y2H	25416956
Intra	TOM1	O60784	TOLLIP	Homo sapiens	Q6FIE9	Y2H Array	25416956
Intra	TOM1	O60784	TOLLIP	Homo sapiens	Q9H0E2-1	Solution Sedimentation	26320582
Intra	TOM1	O60784	TOLLIP	Homo sapiens	Q9H0E2-1	NMR	26320582
Intra	TOM1	O60784	TOLLIP	Homo sapiens	Q9H0E2-1	SPR	26320582
Intra	TOM1	O60784	ZFYVE16	Homo sapiens	Q7Z3T8	Y2H	14613930
Intra	TOM1	O60784	ZFYVE16	Homo sapiens	Q7Z3T8	Anti Tag CoIP	14613930
Intra	TOM1	O60784	ZFYVE16	Homo sapiens	Q7Z3T8	Density Sedimentation	14613930
Intra	TOM1	O60784	ZFYVE16	Homo sapiens	Q7Z3T8	Anti Tag CoIP	33961781
Intra	TOM1	O60784	ZFYVE16	Homo sapiens	Q7Z3T8	Anti Bait CoIP	14613930
Intra	TOM1	O60784	TOLLIP	Homo sapiens	Q9H0E2	Anti Tag CoIP	33961781
Intra	TOM1	O60784	TOLLIP	Homo sapiens	Q9H0E2	Y2H Array	31515488
Intra	TOM1	O60784	TOLLIP	Homo sapiens	Q9H0E2	Y2H Prey Pooling	25416956
Intra	TOM1	O60784	TOLLIP	Homo sapiens	Q9H0E2	CoIP	14563850

Cross: Cross-species interaction Intra: Intraspecies interaction

TOM1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P87114	TOM1 Antibody (YA6807)	WB, IF-Tissue, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Immunodeficiency 85 And Autoimmunity	IMD85 Immunodeficiency 85
Immunodeficiency 31c	IMD31C Candidiasis, Familial, 7 Candf7 Candidiasis, Familial Chronic Mucocutaneous, Autosomal Dominant Autoimmune Enteropathy And Endocrinopathy-Susceptibility To Chronic Infections Syndrome Autoimmune Enteropathy And Endocrinopathy - Susceptibility To Chronic Infections Syndrome Immunodeficiency 31c, Chronic Mucocutaneous Candidiasis, Autosomal Dominant Autosomal Dominant Chronic Mucocutaneous Familial Candidiasis Autosomal Dominant Immunodeficiency 31c Familial Candidiasis 7 Chronic Mucocutaneous Candidiasis 7 Immunodeficiency 31c, Autosomal Dominant Immunodeficiency, Type 31c, Autosomal Dominant
Autoimmune Enteropathy
Combined Immunodeficiency	Combined T Cell And B Cell Immunodeficiency Congenital Combined Immunodeficiency Syndrome With Combined Immunodeficiency Combined T And B Cell Immunodeficiency Combined Immunity Deficiency Combined Immunodeficiency Syndrome Combined T-Cell And B-Cell Immunodeficiency Lymphopenic Agammaglobulinaemia
X-Linked Nephrolithiasis Type I	Nephrolithiasis 1 Nephrolithiasis X-Linked Recessive Type 1 Nphl1 X-Linked Nephrolithiasis With Renal Failure X-Linked Recessive Urolithiasis Type 1 Xrn
Congenital Muscular Dystrophy-Dystroglycanopathy Type A6	Congenital Muscular Dystrophy-Dystroglycanopathy With Brain And Eye Anomalies Type A6 Mddga6 Walker-Warburg Syndrome Or Muscle-Eye-Brain Disease, Large-Related Congenital Muscular Dystrophy-Dystroglycanopathy With Brain And Eye Anomalies, Type A6

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14876	TOM1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14877	TOM1L1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14878	TOM1L2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20830	Tom1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27344	Tom1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TOM1	VGNC	VGNC:66441
Macaca mulatta	TOM1	VGNC	VGNC:78615
Mus musculus	TOM1	MGD	MGI:1338026
Rattus norvegicus	TOM1	RGD	RGD:1308024
Canis familiaris	TOM1	VGNC	VGNC:47707
Bos taurus	TOM1	VGNC	VGNC:36217
Others	TOM1	NCBI