PtdIns-(3)-P1 (1,2-dipalmitoyl) ammonium  (Synonyms: DPPI-3-P ammonium; PIP[3'](16:0/16:0) ammonium; PI(3)P (16:0/16:0) ammonium)

PtdIns-(3)-P1 (1,2-dipalmitoyl) (Compound 7) ammonium is a derivative of phosphatidylinositol 3-phosphate (PtdIns(3)P). phosphatidylinositol 3-phosphate can bind to the FYVE domain of human EEA1 and act as a second messenger in cellular signaling and membrane trafficking. phosphatidylinositol 3-phosphate can stimulate ROS formation by regulating the neutrophil oxidase complex^[1][2][3].

925.07

C₄₁H₈₆N₂O₁₆P₂

CCCCCCCCCCCCCCCC(OC[C@@H](OC(CCCCCCCCCCCCCCC)=O)COP(O[C@@H]1[C@@H]([C@@H]([C@H]([C@@H]([C@H]1O)O)O)OP([O-])(O)=O)O)([O-])=O)=O.[NH4+].[NH4+]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Gokhale NA, et al. Phosphoinositide specificity of and mechanism of lipid domain formation by annexin A2-p11 heterotetramer. J Biol Chem. 2005 Dec 30;280(52):42831-40.  [Content Brief]

  [2]. Ellson CD, et al. PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40(phox). Nat Cell Biol. 2001 Jul;3(7):679-82.  [Content Brief]

  [3]. Kutateladze TG, et al. Phosphatidylinositol 3-phosphate recognition by the FYVE domain. Mol Cell. 1999 Jun;3(6):805-11.