Dnm1 - dynamin 1 Gene

Also Known as Dnm; Ftfl; mKIAA4093

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13429

Summary

This gene encodes a member of the Dynamin subfamily of GTP-binding proteins. The encoded protein is a GTPase which is required for membrane recycling, including vesicle endocytosis in neurons. It may also be involved in cellular fission via association with microtubules and actin filaments. Mutations in this gene have been shown to cause seizures. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

Dnm1 Products (3)

mRNA Protein Name
NM_001301737.1 NP_001288666.1 dynamin-1 isoform 2
NM_001368679.1 NP_001355608.1 dynamin-1 isoform 3
NM_010065.3 NP_034195.2 dynamin-1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GDP binding IDA
IDA: Inferred from direct assay
20428113 MGI
enables GTPase activity IDA
IDA: Inferred from direct assay
19781630 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
20700442 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11956154 MGI
enables protein kinase binding IPI
IPI: Inferred from physical interaction
21307259 MGI
Biological Process GO Annotation Evidence References Source
involved in clathrin coat assembly involved in endocytosis IMP
IMP: Inferred from mutant phenotype
35220002 MGI
involved in modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
24643165 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
24643165 MGI
involved in regulation of vesicle size IMP
IMP: Inferred from mutant phenotype
35220002 MGI
involved in synaptic vesicle endocytosis IDA
IDA: Inferred from direct assay
17463283 MGI
involved in synaptic vesicle endocytosis IMP
IMP: Inferred from mutant phenotype
17463283 MGI
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
24643165 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
24643165 MGI
part of membrane coat IDA
IDA: Inferred from direct assay
11879655 MGI
located in photoreceptor inner segment IDA
IDA: Inferred from direct assay
23746204 MGI
is active in photoreceptor ribbon synapse IDA
IDA: Inferred from direct assay
23785143 MGI
is active in presynaptic endocytic zone membrane IDA
IDA: Inferred from direct assay
23785143 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dynamin-1

Dnm1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Dnm1 P39053 LRRK2 Homo sapiens Q5S007
Anti Tag CoIP
24282027
Intra
Dnm1 P39053 Amph Mus musculus Q7TQF7
Confocal
23640057
Intra
Dnm1 P39053 Amph Mus musculus Q7TQF7
Anti Bait CoIP
23640057
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03904 DNM1L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28663 Dnm1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03903 DNM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17698 Dnm1l Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22142 Dnm1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24160 Dnm1l Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dnm1 NCBI NCBI:1759