Stub1 - STIP1 homology and U-Box containing protein 1 Gene

Also Known as Chip; 0610033N24Rik; 2210017D18Rik; 2310040B03Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 56424

Summary

Enables protein homodimerization activity; ubiquitin protein Ligase binding activity; and ubiquitin-ubiquitin Ligase activity. Involved in several processes, including cellular response to topologically incorrect protein; positive regulation of ubiquitin-protein transferase activity; and proteolysis involved in cellular protein catabolic process. Acts upstream of or within protein polyubiquitination. Located in Z disc. Used to study autosomal recessive spinocerebellar ataxia 16. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 16 and cerebellar ataxia type 48. Orthologous to human STUB1 (STIP1 homology and U-box containing protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Stub1 Products (1)

mRNA	Protein	Name
NM_019719.4	NP_062693.1	E3 ubiquitin-protein ligase CHIP

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16307917	MGI
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	16307917	MGI
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	21855799	MGI
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	21855799	MGI
enables ubiquitin-ubiquitin ligase activity	IDA IDA: Inferred from direct assay	11435423	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to misfolded protein	IMP IMP: Inferred from mutant phenotype	21855799	MGI
involved in endoplasmic reticulum unfolded protein response	IDA IDA: Inferred from direct assay	12150907	MGI
involved in negative regulation of protein binding	IDA IDA: Inferred from direct assay	12150907	MGI
involved in positive regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	12150907	MGI
involved in positive regulation of ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	12150907	MGI
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	21855799	MGI
acts upstream of or within protein polyubiquitination	IDA IDA: Inferred from direct assay	11435423	MGI
involved in protein quality control for misfolded or incompletely synthesized proteins	IMP IMP: Inferred from mutant phenotype	21855799	MGI
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	27273569	MGI
involved in ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	27273569	MGI
involved in ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	18292230	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in Z disc	IDA IDA: Inferred from direct assay	20060297	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	19953350	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase CHIP	RING-type E3 ubiquitin transferase CHIP carboxy terminus of Hsp70-interacting protein

Stub1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Stub1	Q9WUD1	UBE2N	Homo sapiens	P61088	ITC	16307917
Intra	Stub1	Q9WUD1	Ilk	Mus musculus	O55222	Pull Down	23612611
Intra	Stub1	Q9WUD1	Ilk	Mus musculus	O55222	Anti Tag CoIP	23612611
Intra	Stub1	Q9WUD1	Ilk	Mus musculus	O55222	Anti Bait CoIP	23612611

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W1128879	XMU-MP-8	Degrader	99.23%	Unkown
HY-RS13972	STUB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-175686	E3 ligase Ligand 67		98.69%	Unkown
HY-RS17083	Stub1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23527	Stub1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Stub1	NCBI	NCBI:10273