LARP4 - La ribonucleoprotein 4 Gene

Also Known as PP13296

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 113251

About LARP4

Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:50,400,885-50,480,004 (from NCBI)

This gene has 18 transcripts (splice variants), 317 orthologues and 6 paralogues. Ubiquitous expression in liver (RPKM 13.3), adrenal (RPKM 12.0) and 25 other tissues.

Summary

Enables mRNA 3'-UTR binding activity and poly(A) binding activity. Involved in Cytoskeleton organization; positive regulation of translation; and regulation of cell morphogenesis. Located in cytosol. Colocalizes with cytoplasmic stress granule; cytosolic small ribosomal subunit; and polysome. [provided by Alliance of Genome Resources, Apr 2022]

LARP4 Products (30)

mRNA Protein Name
NM_001170803.2 NP_001164274.1 la-related protein 4 isoform d
NM_001170804.2 NP_001164275.1 la-related protein 4 isoform e
NM_001170808.2 NP_001164279.1 la-related protein 4 isoform f
NM_001330415.2 NP_001317344.1 la-related protein 4 isoform g
NM_001352304.2 NP_001339233.1 la-related protein 4 isoform h
NM_001352305.2 NP_001339234.1 la-related protein 4 isoform i
NM_001352306.2 NP_001339235.1 la-related protein 4 isoform j
NM_001352307.2 NP_001339236.1 la-related protein 4 isoform k
NM_001352308.2 NP_001339237.1 la-related protein 4 isoform l
NM_001352309.2 NP_001339238.1 la-related protein 4 isoform m
NM_001352310.2 NP_001339239.1 la-related protein 4 isoform m
NM_001352311.2 NP_001339240.1 la-related protein 4 isoform m
NM_001352312.2 NP_001339241.1 la-related protein 4 isoform m
NM_001352313.2 NP_001339242.1 la-related protein 4 isoform m
NM_001352314.2 NP_001339243.1 la-related protein 4 isoform m
NM_001352315.2 NP_001339244.1 la-related protein 4 isoform n
NM_001352316.2 NP_001339245.1 la-related protein 4 isoform o
NM_001352317.2 NP_001339246.1 la-related protein 4 isoform o
NM_001352318.2 NP_001339247.1 la-related protein 4 isoform p
NM_001352319.2 NP_001339248.1 la-related protein 4 isoform q
NM_001352320.2 NP_001339249.1 la-related protein 4 isoform r
NM_001352321.2 NP_001339250.1 la-related protein 4 isoform s
NM_001352322.2 NP_001339251.1 la-related protein 4 isoform t
NM_001352323.2 NP_001339252.1 la-related protein 4 isoform u
NM_001352324.2 NP_001339253.1 la-related protein 4 isoform h
NM_001352325.2 NP_001339254.1 la-related protein 4 isoform v
NM_001352326.2 NP_001339255.1 la-related protein 4 isoform w
NM_052879.5 NP_443111.4 la-related protein 4 isoform a
NM_199188.3 NP_954658.2 la-related protein 4 isoform b
NM_199190.3 NP_954660.1 la-related protein 4 isoform c

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables mRNA 3'-UTR binding IDA
IDA: Inferred from direct assay
26001795 GOA
enables poly(A) binding IDA
IDA: Inferred from direct assay
21098120 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21098120 GOA
Biological Process GO Annotation Evidence References Source
involved in cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
21834987 GOA
involved in positive regulation of translation IMP
IMP: Inferred from mutant phenotype
21098120 GOA
involved in post-transcriptional regulation of gene expression IDA
IDA: Inferred from direct assay
26001795 GOA
involved in regulation of cell morphogenesis IMP
IMP: Inferred from mutant phenotype
21834987 GOA
Cellular Component GO Annotation Evidence References Source
colocalizes with cytoplasmic stress granule IDA
IDA: Inferred from direct assay
21098120 GOA
located in cytosol IDA
IDA: Inferred from direct assay
21098120 GOA
part of cytosolic small ribosomal subunit IDA
IDA: Inferred from direct assay
21098120 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LARP4 Protein Structure

La

La: La domain (123 - 180)

  • 0
  • 200
  • 400
  • 600
  • 724 a.a.
Protein Preferred Names Protein Names

la-related protein 4

  • La ribonucleoprotein domain family member 4

LARP4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LARP4 Q71RC2 LRRK2 Homo sapiens Q5S007
Protein Array
29513927
Intra
LARP4 Q71RC2 NPM1 Homo sapiens P06748
Crosslink
30021884
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Embryonal Testis Carcinoma

  • Testicular Embryonal Carcinoma

  • Embryonal Carcinoma Of Testis

  • Embryonal Carcinoma Of The Testis
Essential Thrombocythemia

  • Essential Thrombocytosis

  • Familial Thrombocytosis

  • Hemorrhagic Thrombocythemia

  • Hereditary Thrombocythemia

  • Primary Thrombocytosis

  • Idiopathic Thrombocythemia

  • Primary Thrombocythemia

  • Thrombocythemia, Essential

  • Essential Thrombocythaemia

  • Et

  • Familial Thrombocythemia

  • Thrombocythemia Essential
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07528 LARP4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07529 LARP4B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris LARP4 VGNC VGNC:42589
Felis catus LARP4 VGNC VGNC:63193
Rattus norvegicus LARP4 RGD RGD:6499275
Bos taurus LARP4 VGNC VGNC:55059
Mus musculus LARP4 MGD MGI:2443114
Macaca mulatta LARP4 VGNC VGNC:74111
Others LARP4 NCBI