1. Autophagy
  2. LRRK2
  3. LRRK2-IN-6

LRRK2-IN-6 

Cat. No.: HY-151444
Handling Instructions

LRRK2-IN-6 (compound 22) is a potent, orally active, selective leucine rich repeat protein kinase 2 gene (LRRK2) inhibitor with IC50 values of 4.6 and 49 μM for GS LRRK2 and WT LRRK2, respectively. LRRK2-IN-6 inhibits LRRK2 Ser1292 and Ser925 autophosphorylation. LRRK2-IN-6 can cross the blood-brain barrier.

For research use only. We do not sell to patients.

LRRK2-IN-6 Chemical Structure

LRRK2-IN-6 Chemical Structure

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

LRRK2-IN-6 (compound 22) is a potent, orally active, selective leucine rich repeat protein kinase 2 gene (LRRK2) inhibitor with IC50 values of 4.6 and 49 μM for GS LRRK2 and WT LRRK2, respectively. LRRK2-IN-6 inhibits LRRK2 Ser1292 and Ser925 autophosphorylation. LRRK2-IN-6 can cross the blood-brain barrier[1].

IC50 & Target

IC50: 4.6 (GS LRRK2) and 49 μM (GS LRRK2)[1]

In Vitro

LRRK2-IN-6 (compound 22; 0-10000 nM; 24 h; HEK293 cells) has excellent potency and GS-LRRK2 selectivity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: HEK293 cells
Concentration: 0, 30, 100, 300, 1000, 3000, and 10000 nM
Incubation Time: 24 hours
Result: Reduced GS-LRRK2 pSer935 and GS-LRRK2 pSer1292 autophosphorylation levels over WT-LRRK2.
In Vivo

LRRK2-IN-6 (compound 22; 0.5 mg/kg (i.v.) and 5 mg/kg (p.o.); CD-1 mice) has good pharmacokinetic parametershigh and high bioavailability[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CD-1 mice[1]
Dosage: 0.5 mg/kg (i.v.) and 5 mg/kg (p.o.)
Administration: Intravenous injection and oral administration
Result: 1.19
Route of Administration IV PO
Dose (mg/kg) 0.5 5
AUCinf (μM*h) 0.71 11.9
Cmax (μM) 0.53 1.86
Tmax (h) 0.08 1.33
T1/2 (h) 1.09 5.40
MRT (h) 1.17 6.40
CL (mL/min) 26.1
F (%) 174
Molecular Weight

458.52

Formula

C23H24F2N4O2S

SMILES

CC1=C(C(C2=CC=NC=C2)=NN1)C3=CC(F)=C(C(F)=C3)N4CCC5(C4)CCS(=O)(CC5)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
LRRK2-IN-6
Cat. No.:
HY-151444
Quantity:
MCE Japan Authorized Agent: