2892451-17-9
Chemical Structure
LRRK2-IN-6
- CAS 番号: 2892451-17-9
- Formula:C23H24F2N4O2S
- Molecular Weight:458.52
IUPAC Name: 2-(2,6-difluoro-4-(5-methyl-3-(pyridin-4-yl)-1H-pyrazol-4-yl)phenyl)-8-thia-2-azaspiro[4.5]decane 8,8-dioxide
InChIKey: ZTQLTVVZCKVDKJ-UHFFFAOYSA-N
SMILES: CC1=C(C(C2=CC=NC=C2)=NN1)C3=CC(F)=C(C(F)=C3)N4CCC5(C4)CCS(=O)(CC5)=O
Biological Activity: LRRK2-IN-6 (compound 22) is a potent, orally active, selective leucine rich repeat protein kinase 2 gene (LRRK2) inhibitor with IC50 values of 4.6 and 49 μM for GS LRRK2 and WT LRRK2, respectively. LRRK2-IN-6 inhibits LRRK2 Ser1292 and Ser925 autophosphorylation. LRRK2-IN-6 can cross the blood-brain barrier[1].
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LRRK2-IN-6 | LRRK2-IN-6 (compound 22) is a potent, orally active, selective leucine rich repeat protein kinase 2 gene (LRRK2) inhibitor with IC50 values of 4.6 and 49 μM for GS LRRK2 and WT LRRK2, respectively. LRRK2-IN-6 inhibits LRRK2 Ser1292 and Ser925 autophosphorylation. LRRK2-IN-6 can cross the blood-brain barrier. | |||||||||||||||||||||
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Keywords
