SLC25A6 - solute carrier family 25 member 6 Gene

Also Known as ANT; AAC3; ANT3; ANT 2; ANT 3; ANT3Y

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 293

About SLC25A6

Cytogenetic location: Xp22.33 Genomic coordinates (GRCh38): X:1,386,152-1,392,113 (from NCBI)

This gene has 3 transcripts (splice variants), 124 orthologues and 49 paralogues. Ubiquitous expression in kidney (RPKM 238.9), ovary (RPKM 226.6) and 25 other tissues.

Summary

This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein is implicated in the function of the permability transition pore complex (PTPC), which regulates the release of mitochondrial products that induce Apoptosis. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Jun 2013]

SLC25A6 Products (1)

mRNA	Protein	Name
NM_001636.4	NP_001627.2	ADP/ATP translocase 3

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16201016	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in membrane	IDA IDA: Inferred from direct assay	27641616	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC25A6 Protein Structure

Mito_carr

0
100
200
298 a.a.

Protein Preferred Names	Protein Names
ADP/ATP translocase 3	ADP,ATP carrier protein 3

SLC25A6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SLC25A6	P12236	MID2	Homo sapiens	Q9UJV3-2	Y2H Prey Pooling	25416956
Intra	SLC25A6	P12236	MID2	Homo sapiens	Q9UJV3-2	Y2H Array	25416956
Intra	SLC25A6	P12236	VDAC1	Homo sapiens	P21796	Anti Tag CoIP	21370995
Intra	SLC25A6	P12236	AP2B1	Homo sapiens	P63010	Validated Y2H	25416956
Intra	SLC25A6	P12236	TRIM23	Homo sapiens	P36406	Validated Y2H	25416956
Intra	SLC25A6	P12236	LZTS2	Homo sapiens	Q9BRK4	Y2H Array	25416956
Intra	SLC25A6	P12236	TEKT4	Homo sapiens	Q8WW24	Validated Y2H	25416956
Intra	SLC25A6	P12236	TEKT4	Homo sapiens	Q8WW24	Y2H Prey Pooling	25416956
Intra	SLC25A6	P12236	TEKT4	Homo sapiens	Q8WW24	Y2H Array	25416956
Intra	SLC25A6	P12236	NOTCH2NLA	Homo sapiens	Q7Z3S9	Validated Y2H	25416956
Cross	SLC25A6	P12236	PB1	Influenza A virus	P0C0U1	Anti Tag CoIP	16201016

Cross: Cross-species interaction Intra: Intraspecies interaction

SLC25A6 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811014	ANT3 Antibody	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Influenza	Flu Influenza With Non-Respiratory Manifestation Influenza With Other Manifestations Influenza, Human Influenza, Susceptibility To Seasonal Influenza, Virus Identified
Bubonic Plague	Black Death Plague, Bubonic Plague, Septicemic Pestis Bubonica
Plague	Yersiniosis Yersinia Infections Infection By Yersinia Pestis Pasteurella Pestis Infection Pestilential Fever Yersinia Pestis Infection

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13133	SLC25A6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SLC25A6	VGNC	VGNC:49967
Canis familiaris	SLC25A6	VGNC	VGNC:54600
Rattus norvegicus	SLC25A6	RGD	RGD:1560896
Others	SLC25A6	NCBI