MAP2K7 - mitogen-activated protein kinase kinase 7 Gene

Homo sapiens

Also known as MEK; MKK7; JNKK2; MEK 7; MAPKK7; PRKMK7; SAPKK4; SAPKK-4

Gene ID: 5609 | Gene type: protein coding

About MAP2K7

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:7,903,877-7,914,478 (from NCBI)

This gene has 8 transcripts (splice variants), 196 orthologues and 8 paralogues. Ubiquitous expression in testis (RPKM 9.3), spleen (RPKM 8.9) and 25 other tissues.

Summary

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

MAP2K7 Products(3)

mRNA	Protein	Name
NM_001297555.2	NP_001284484.1	dual specificity mitogen-activated protein kinase kinase 7 isoform 1
NM_001297556.2	NP_001284485.1	dual specificity mitogen-activated protein kinase kinase 7 isoform 2
NM_145185.4	NP_660186.1	dual specificity mitogen-activated protein kinase kinase 7 isoform 3

MAP2K7 Protein Structure

Pkinase

0
100
200
300
419 a.a.

Protein Preferred Names

Protein Names

dual specificity mitogen-activated protein kinase kinase 7

JNK-activating kinase 2

Related Diseases

Diseases

Alias

Cardiomyopathy, Familial Hypertrophic, 25

Hypertrophic Cardiomyopathy 25	CMH25
Cardiomyopathy, Hypertrophic, 25	Cardiomyopathy Familial Hypertrophic 25
Cardiomyopathy, Familial Hypertrophic 25	Cardiomyopathy, Hypertrophic, Type 25

Fallopian Tube Clear Cell Adenocarcinoma

Clear Cell Carcinoma Of The Fallopian Tube

Mucocele Of Appendix

Appendicele Mucocele	Appendicular Mucocele
Appendiceal Mucocele

Fallopian Tube Endometriosis

Endometriosis Of Fallopian Tube

Adenomyosis Of Fallopian Tube

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08045	MAP2K7 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MAP2K7	RGD	RGD:1560043
Canis familiaris	MAP2K7	VGNC	VGNC:42965
Macaca mulatta	MAP2K7	VGNC	VGNC:81457
Bos taurus	MAP2K7	VGNC	VGNC:54447
Mus musculus	MAP2K7	MGD	MGI:1346871
Felis catus	MAP2K7	VGNC	VGNC:80622
Others	MAP2K7	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.